Homocysteine Levels and the Risk of Osteoporotic Fracture, New England Journal of Medicine, vol.350, issue.20, pp.2033-2041, 2003. ,
DOI : 10.1056/NEJMoa032546
Hyperhomocyst(e)inemia as a Risk Factor for Occlusive Vascular Disease, Annual Review of Nutrition, vol.12, issue.1, pp.279-298, 1992. ,
DOI : 10.1146/annurev.nu.12.070192.001431
Endothelial dysfunction and atherothrombosis in mild hyperhomocysteinemia, Vascular Medicine, vol.104, issue.3, pp.227-239, 2002. ,
DOI : 10.1161/hc3501.095358
Increased Homocysteine and S-Adenosylhomocysteine Concentrations and DNA Hypomethylation in Vascular Disease, Clinical Chemistry, vol.49, issue.8, pp.1292-1296, 2003. ,
DOI : 10.1373/49.8.1292
Homocysteine and DNA methylation: A review of animal and human literature, Molecular Genetics and Metabolism, vol.113, issue.4, pp.243-252, 2014. ,
DOI : 10.1016/j.ymgme.2014.10.006
Protein Phosphatase 2A Methyltransferase Links Homocysteine Metabolism with Tau and Amyloid Precursor Protein Regulation, Journal of Neuroscience, vol.27, issue.11, pp.2751-2759, 2007. ,
DOI : 10.1523/JNEUROSCI.3316-06.2007
Hepatic Acyl-Coenzyme A:Cholesterol Acyltransferase-2 Expression Is Decreased in Mice with Hyperhomocysteinemia, The Journal of Nutrition, vol.123, issue.2, pp.231-237, 2010. ,
DOI : 10.1194/jlr.M400450-JLR200
Epigenetic regulation of glucocorticoid receptor expression in aorta from mice with hyperhomocysteinemia, Epigenetics, vol.333, issue.5, pp.514-521, 2012. ,
DOI : 10.1016/j.ab.2004.05.007
and Altered Hepatic Fatty Acid and Phospholipid Metabolism in Mice with Hyperhomocysteinemia, Journal of Biological Chemistry, vol.264, issue.51, pp.37082-37090, 2007. ,
DOI : 10.1161/01.CIR.0000129138.08493.4D
Epigenetic alterations in folate transport genes in placental tissuefrom fetuses with neural tube defects and in leukocytes from subjects with hyperhomocysteinemia.Epigenetics8, pp.303-316, 2013. ,
Homocysteine promotes human endothelial cell dysfunction via site-specific epigenetic regulation of p66shc, Cardiovascular Research, vol.282, issue.3, pp.466-475, 2011. ,
DOI : 10.1074/jbc.M704256200
Homocysteinylated protein levels in internal mammary artery (IMA) fragments and its genotype-dependence. S-Homocysteine-induced methylation modifications in IMA and aortic fragments, Molecular and Cellular Biochemistry, vol.52, issue.4, pp.235-246, 2012. ,
DOI : 10.1373/clinchem.2006.071142
Hypermethylation of estrogen receptor-alpha gene in atheromatosis patients and its correlation withhomocysteine, pp.259-265, 2009. ,
Methylation of estrogen receptor ?? and mutL homolog 1 in normal colonic mucosa: association with folate and vitamin B-12 status in subjects with and without colorectal neoplasia, The American Journal of Clinical Nutrition, vol.53, issue.4, pp.1064-1072, 2007. ,
DOI : 10.1136/gut.2003.030841
The effect of modifiable potentials on hypermethylation status of retinoicacid receptor-beta2 and estrogen receptor-alpha genes in primary breast cancer.Cancer Causes Control21, pp.2101-2111, 2010. ,
DNA methylation in esophageal diseases including cancer: special reference to hMLH1 genepromoter status, Tumori, vol.92, pp.155-162, 2006. ,
Impact of Hyperhomocysteinemia on Breast Cancer Initiation and Progression: Epigenetic Perspective, Cell Biochemistry and Biophysics, vol.6, issue.1, pp.397-406, 2014. ,
DOI : 10.1371/journal.pone.0016080
Ischemic Heart Disease and Stroke in Relation to Blood DNA Methylation, Epidemiology, vol.21, issue.6, pp.819-828, 2010. ,
DOI : 10.1097/EDE.0b013e3181f20457
DNA methylation status is not impaired in treated cystathionine beta-synthase (CBS) deficient patients, Molecular Genetics and Metabolism, vol.91, issue.1, pp.55-60, 2007. ,
DOI : 10.1016/j.ymgme.2007.01.008
Global DNA Methylation Not Increased in Chronic Hemodialysis Patients: A Case???Control Study, Renal Failure, vol.66, issue.2, pp.1195-1199, 2012. ,
DOI : 10.1158/0008-5472.CAN-05-1537
The Rotterdam Study: 2016 objectives and design update, European Journal of Epidemiology, vol.6, issue.1, pp.661-708, 2015. ,
DOI : 10.14336/AD.2014.0128
Nonagenarian Siblings and Their Offspring Display Lower Risk of Mortality and Morbidity than Sporadic Nonagenarians: The Leiden Longevity Study, Journal of the American Geriatrics Society, vol.167, issue.9, pp.1634-1637, 2009. ,
DOI : 10.1093/gerona/59.4.M385
Human plasma complement C3 is independently associated with coronary heart disease, but only in heavy smokers (the CODAM study), International Journal of Cardiology, vol.154, issue.2, pp.158-162, 2012. ,
DOI : 10.1016/j.ijcard.2010.09.017
A multi-stage multi-design strategy provides strong evidence that the BAI3 locus is associated with early-onset venous thromboembolism, Journal of Thrombosis and Haemostasis, vol.207, issue.12, pp.2671-2679, 2010. ,
DOI : 10.1086/321195
Cohort Profile: Estonian Biobank of the Estonian Genome Center, University of Tartu, International Journal of Epidemiology, vol.44, issue.4, pp.1137-1147, 2015. ,
DOI : 10.1038/nature11677
Understanding StatisticsHigh density DNA methylation array with single CpG site resolution, UKGenomics, vol.98, pp.288-295, 1996. ,
A data-driven approach to preprocessing Illumina 450 K methylation array data, BMC Genomics14, p.293, 2013. ,
SWAN: Subset-quantile Within Array Normalization for Illumina Infinium HumanMethylation450 BeadChips, Genome Biology, vol.13, issue.6, p.44, 2012. ,
DOI : 10.1186/1471-2105-11-587
Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays, Bioinformatics, vol.8, issue.10, pp.1363-1369, 2014. ,
DOI : 10.4161/epi.25501
METAL: fast and efficient meta-analysis of genomewide association scans, Bioinformatics, vol.40, issue.5, pp.2190-2191, 2010. ,
DOI : 10.1038/ng.120
Disease variants alter transcription factor levels and methylation of their binding sites, pp.131-138, 2015. ,
Genomic Control for Association Studies, Biometrics, vol.280, issue.4, pp.997-1004, 1999. ,
DOI : 10.1126/science.280.5366.1077
GREAT improves functional interpretation of cis-regulatory regions, Nature Biotechnology, vol.113, issue.5, pp.495-501, 2010. ,
DOI : 10.1016/S0092-8674(03)00310-6
The UCSC Genome Browser database: 2016 update, Nucleic Acids Research, vol.44, issue.D1, pp.717-725, 2016. ,
DOI : 10.1126/science.1262110
Loss of imprinting and aberrant methylation of IGF2 in placentas from pregnancies complicated with fetal growth restriction, Int. J. Mol. Med, vol.28, pp.481-487, 2011. ,
Altered gene expression and methylation of the human chromosome 11 imprinted region in small for gestational age (SGA) placentae, Dev. Biol, vol.320, pp.79-91, 2008. ,
Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns, Nature Communications, vol.10, p.10577, 2016. ,
DOI : 10.1186/1471-2105-10-48
Comb-p: software for combining, analyzing, grouping and correcting spatially correlated P-values, Bioinformatics, vol.22, issue.2, pp.2986-2988, 2012. ,
DOI : 10.1002/gepi.0042
A modified generalized Fisher method for combining probabilities from dependent tests, Frontiers in Genetics, vol.5, p.32, 2014. ,
DOI : 10.3389/fgene.2014.00032
The American Soldier: Adjustment During Army Life (Volume I), 1949. ,
On the combination of independent tests. Magyar Tudomanyos, Akademia Matematikai Kutato Intezetenek Kozlemenyei, vol.3, pp.171-197, 1958. ,
Rectangular Confidence Regions for the Means of Multivariate Normal Distributions, Journal of the American Statistical Association, vol.62, issue.318, pp.626-633, 1967. ,
DOI : 10.2307/2283989
WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013, Nucleic Acids Research, vol.37, issue.W1, pp.77-83, 2013. ,
DOI : 10.1093/nar/gkn923
URL : https://academic.oup.com/nar/article-pdf/41/W1/W77/16943558/gkt439.pdf
The human fatty acid transport protein-1 (SLC27A1 ,
A combination of omega-3 fatty acids, folic acid and B-group vitamins is superior at lowering homocysteine than omega-3 alone: A meta-analysis, Nutrition Research, vol.36, issue.6, pp.499-508, 2016. ,
DOI : 10.1016/j.nutres.2016.03.010
Oocytes in a Grb2- and Ras-Dependent Manner, Molecular and Cellular Biology, vol.19, issue.6, pp.4379-4389, 1999. ,
DOI : 10.1128/MCB.19.6.4379
Ajuba, a Cytosolic LIM Protein, Shuttles into the Nucleus and Affects Embryonal Cell Proliferation and Fate Decisions, Molecular Biology of the Cell, vol.11, issue.10, pp.3299-3313, 2000. ,
DOI : 10.1091/mbc.11.10.3299
LIM protein Ajuba functions as a nuclear receptor corepressor and negatively regulates retinoic acid signaling, Proc. Natl Acad. Sci. USA, pp.2938-2943, 2010. ,
Ajuba LIM Proteins Are Negative Regulators of the Hippo Signaling Pathway, Current Biology, vol.20, issue.7, pp.657-662, 2010. ,
DOI : 10.1016/j.cub.2010.02.035
LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade, Oncogene, vol.209, issue.1, pp.73-83, 2015. ,
DOI : 10.1084/jem.20111653
A BK (Slo1) channel journey from molecule to physiology, Channels, vol.85, issue.6, pp.442-458, 2013. ,
DOI : 10.1007/s00232-005-0830-z
Modulation by homocysteine of the iberiotoxin-sensitive, Ca2+-activated K+ channels of porcine coronary artery smooth muscle cells, European Journal of Pharmacology, vol.546, issue.1-3 ,
DOI : 10.1016/j.ejphar.2006.06.073
Large-conductance Ca2+-activated K+ currents blocked and impaired by homocysteine in human and rat mesenteric artery smooth muscle cells, Life Sciences, vol.80, issue.22, pp.2060-2066, 2007. ,
DOI : 10.1016/j.lfs.2007.03.003
Tenascin-X: a novel extracellular matrix protein encoded by the human XB gene overlapping P450c21B, The Journal of Cell Biology, vol.122, issue.1, pp.265-278, 1993. ,
DOI : 10.1083/jcb.122.1.265
DNA methylation in individuals with anorexia nervosa and in matched normal-eater controls: A genome-wide study, International Journal of Eating Disorders, vol.28, issue.7, pp.874-882, 2015. ,
DOI : 10.1089/neu.2010.1648
High-throughput DNA methylation analysis in anorexia nervosa confirms TNXBhypermethylation, World J. Biol ,
Homocysteine Upregulates Soluble Epoxide Hydrolase in Vascular Endothelium In Vitro and In Vivo, Circulation Research, vol.110, issue.6, pp.808-817, 2012. ,
DOI : 10.1161/CIRCRESAHA.111.259325
The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects, Clinical Epigenetics, vol.8, issue.8, p.121, 2015. ,
DOI : 10.4161/epi.25430
Novel Associations of CPS1, MUT, NOX4, and DPEP1 With Plasma Homocysteine in a Healthy Population: A Genome-Wide Evaluation of 13 974 Participants in the Women's Genome Health Study, Circulation: Cardiovascular Genetics, vol.2, issue.2, pp.142-150, 2009. ,
DOI : 10.1161/CIRCGENETICS.108.829804
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease, The American Journal of Clinical Nutrition, vol.28, issue.3, pp.668-676, 2013. ,
DOI : 10.1161/ATVBAHA.108.162743
Genetic modifiers of folate, vitamin B-12, and homocysteine status in a cross-sectional study of the Canadian population, The American Journal of Clinical Nutrition, vol.37, issue.Suppl, pp.1295-1304, 2015. ,
DOI : 10.1038/ng1669
Citrullination of DNMT3A by PADI4 regulates its stability and controls DNA methylation, Nucleic Acids Research, vol.29, issue.13, pp.8285-8296, 2014. ,
DOI : 10.1016/j.cell.2007.01.029
Establishing an analytic pipeline for genome-wide DNA methylation, Clinical Epigenetics, vol.8, issue.Web Server issu, p.45, 2016. ,
DOI : 10.1186/s13072-015-0045-1
Analysing and interpreting DNA methylation data, Nature Reviews Genetics, vol.3, issue.10, pp.705-719, 2012. ,
DOI : 10.1016/S1046-2023(02)00060-9
Denovoidentification of differentially methylated regions in the human genome, EpigeneticsChromatin, vol.8, p.6, 2015. ,
seqlm: an MDL based method for identifying differentially methylated regions in high density methylation array data, Bioinformatics, vol.9, issue.17, pp.2604-2610, 2016. ,
DOI : 10.3389/fgene.2012.00161
Genome-wide Association Study of Vitamin B6, Vitamin B12, Folate, and Homocysteine Blood Concentrations, The American Journal of Human Genetics, vol.84, issue.4, pp.477-482, 2009. ,
DOI : 10.1016/j.ajhg.2009.02.011
HOMOCYSTEINE METABOLISM, Annual Review of Nutrition, vol.19, issue.1, pp.217-246, 1999. ,
DOI : 10.1146/annurev.nutr.19.1.217
Associations among objectively measured physical activity, fasting plasma homocysteine concentration, and MTHFR C677T genotype, European Journal of Applied Physiology, vol.88, issue.1, pp.2997-3005, 2011. ,
DOI : 10.1007/s00421-008-0883-7