Systemic inhibition and liver-specific over-expression of PAI-1 failed to improve survival in all-inclusive populations or homogenous cohorts of CLP mice

P. Raeven (1) , S. Drechsler (1) , K. M. Weixelbaumer (1) , Delphine Bastelica (2) , Franck Peiretti (2) , A. Klotz (1) , M. Jafarmadar (1) , H. Redl (1) , S. Bahrami (1) , Marie-Christine Alessi (2) , P. J. Declerck (3) , M. F. Osuchowski (1)

1 Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the Research Center of AUVA
2 NORT - Nutrition, obésité et risque thrombotique
3 Laboratory for Therapeutic and Diagnostic Antibodies [KU Leuven]

Domains: Life Sciences [q-bio]; Human health and pathology; Cardiology and cardiovascular system; Life Sciences [q-bio]; Human health and pathology; Hematology; Life Sciences [q-bio]; Human health and pathology; Endocrinology and metabolism

P. Raeven, S. Drechsler, K. M. Weixelbaumer, Delphine Bastelica, Franck Peiretti, et al.. Systemic inhibition and liver-specific over-expression of PAI-1 failed to improve survival in all-inclusive populations or homogenous cohorts of CLP mice. Journal of Thrombosis and Haemostasis, 2014, 12 (6), pp.958 - 969. ⟨10.1111/jth.12565⟩. ⟨hal-01754836⟩