An Early Postnatal Oxytocin Treatment Prevents Social and Learning Deficits in Adult Mice Deficient for Magel2, a Gene Involved in Prader-Willi Syndrome and Autism

Hamid Meziane (1) , Fabienne Schaller (2) , Sylvian Bauer (2) , Claude Villard (3, 4) , Valéry Matarazzo (2) , Fabrice Riet (1) , Gilles Guillon (5) , Daniel Lafitte (4, 3) , Michel G Desarménien (5) , Maïthé Tauber (6) , Françoise Muscatelli (2)

1 ICS - Institut Clinique de la Souris
2 INMED - INSERM U901 - Institut de Neurobiologie de la Méditerranée [Aix-Marseille Université]
3 Plateforme Protéomique et Innovation Technologique
4 CRO2 - Centre de Recherches en Oncologie biologique et Oncopharmacologie
5 IGF - Institut de Génomique Fonctionnelle
6 Centre de Référence du Syndrome de Prader-Willi

Mutations of MAGEL2 have been reported in patients presenting with autism, and loss of MAGEL2 is also associated with Prader-Willi syndrome, a neurodevelopmental genetic disorder. This study aimed to determine the behavioral phenotype of Magel2-deficient adult mice, to characterize the central oxytocin (OT) system of these mutant mice, and to test the curative effect of a peripheral OT treatment just after birth.

Keywords: Autism spectrum disorder; MAGEL2; Neurodevelopment; Oxytocin; Prader-Willi syndrome; Therapy

Domains: Life Sciences [q-bio]; Life Sciences [q-bio]; Biochemistry, Molecular Biology; Life Sciences [q-bio]; Cellular Biology

Hamid Meziane, Fabienne Schaller, Sylvian Bauer, Claude Villard, Valéry Matarazzo, et al.. An Early Postnatal Oxytocin Treatment Prevents Social and Learning Deficits in Adult Mice Deficient for Magel2, a Gene Involved in Prader-Willi Syndrome and Autism. Biological Psychiatry, 2015, 78 (2), pp.85 - 94. ⟨10.1016/j.biopsych.2014.11.010⟩. ⟨hal-01756947⟩