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An Early Postnatal Oxytocin Treatment Prevents Social and Learning Deficits in Adult Mice Deficient for Magel2, a Gene Involved in Prader-Willi Syndrome and Autism

Abstract : Mutations of MAGEL2 have been reported in patients presenting with autism, and loss of MAGEL2 is also associated with Prader-Willi syndrome, a neurodevelopmental genetic disorder. This study aimed to determine the behavioral phenotype of Magel2-deficient adult mice, to characterize the central oxytocin (OT) system of these mutant mice, and to test the curative effect of a peripheral OT treatment just after birth.
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https://hal-amu.archives-ouvertes.fr/hal-01756947
Contributor : Ludovic Leloup <>
Submitted on : Tuesday, April 3, 2018 - 11:20:02 AM
Last modification on : Saturday, October 31, 2020 - 3:08:25 AM

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Hamid Meziane, Fabienne Schaller, Sylvian Bauer, Claude Villard, Valéry Matarazzo, et al.. An Early Postnatal Oxytocin Treatment Prevents Social and Learning Deficits in Adult Mice Deficient for Magel2, a Gene Involved in Prader-Willi Syndrome and Autism. Biological Psychiatry, Elsevier, 2015, 78 (2), pp.85 - 94. ⟨10.1016/j.biopsych.2014.11.010⟩. ⟨hal-01756947⟩

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