Gene therapies for inherited skin disorders, Semin. Cutan. Med. Surg, vol.33, issue.2, pp.83-90, 2014. ,
A rapid and potent DNA vaccination strategy defined by in vivo monitoring of antigen expression, Nat. Med, vol.11, pp.899-904, 2005. ,
Cutaneous DNA delivery and gene expression in ex vivo human skin explants via wet-etch microfabricated microneedles, J. Drug Target, vol.13, issue.7, pp.415-442, 2005. ,
Cutaneous gene expression of plasmid DNA in excised human skin following delivery via microchannels created by radio frequency ablation, Int. J. Pharm, vol.312, issue.1-2, pp.15-23, 2006. ,
Hydrodynamic gene delivery and its applications in pharmaceutical research, Pharm. Res, vol.28, issue.4, pp.694-701, 2011. ,
Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line, J. Cell Biol, vol.106, pp.761-771, 1988. ,
Non-viral and viral vectors for gene therapy, Cell Mol. Biol, vol.2, issue.51, pp.3-22, 2005. ,
Iontophoretic delivery of atelomeric oligonucleotide, Pharm. Res, vol.13, pp.851-854, 1996. ,
Prototype development and preclinical immunogenicity analysis of a novel minimally invasive electroporation device, Mol. Ther, vol.3, pp.249-255, 2011. ,
In vivo gene transfer by low-volume jet injection, Anal. Biochem, vol.282, pp.262-265, 2000. ,
Microfabricated silicon microneedles for nonviral cutaneous gene delivery, Br. J. Dermatol, vol.150, issue.5, pp.869-877, 2004. ,
Minimally invasive cutaneous delivery of macromolecules and plasmid DNA via microneedles, Curr. Drug Deliv, vol.3, issue.1, pp.65-75, 2006. ,
Hollow microneedle arrays for intradermal drug delivery and DNA electroporation, J. Membr. Biol, vol.236, pp.117-125, 2010. ,
DOI : 10.1007/s00232-010-9283-0
Polymer multilayer tattooing for enhanced DNA vaccination, Nat. Mater, vol.12, issue.4, pp.367-376, 2013. ,
Nuclear entry of nonviral vectors, Gene Ther, vol.12, issue.11, pp.881-890, 2005. ,
DOI : 10.1038/sj.gt.3302534
URL : https://www.nature.com/articles/3302534.pdf
Cutaneous transfection and immune responses to intradermal nucleic acid vaccination are significantly enhanced by in vivo electropermeabilization, Mol. Ther, vol.3, pp.249-255, 2001. ,
Critical assessment of the nuclear import of plasmid during cationic lipid-mediated gene transfer, J. Gene Med, vol.3, issue.2, pp.179-187, 2001. ,
A needleless liquid jet injection delivery method for cardiac gene therapy: a comparative evaluation versus standard routes of delivery reveals enhanced therapeutic retention and cardiac specific gene expression, J. Cardiovasc. Transl. Res, vol.7, issue.8, pp.756-767, 2014. ,
Liquid jet delivery method featuring S100A1 gene therapy in the rodent model following acute myocardial infarction, Gene Ther, vol.23, pp.151-157, 2016. ,
DOI : 10.1038/gt.2015.100
URL : http://europepmc.org/articles/pmc4742412?pdf=render
Gene transfer into mammalian cells by jet injection, Hybridoma, vol.14, pp.149-152, 1995. ,
Haematoxylin and eosin staining of tissue and cell sections, CSH Protoc, 2008. ,
DOI : 10.1101/pdb.prot4986
Cutaneous vaccination using microneedles coated with hepatitis C DNA vaccine, Gene Ther, vol.17, issue.6, pp.811-814, 2010. ,
DOI : 10.1038/gt.2010.22
URL : https://www.nature.com/articles/gt201022.pdf
Increased interstitial pressure improves nucleic acid delivery to skin enabling a comparative analysis of constitutive promoters, Gene Ther, vol.17, pp.1270-1278, 2010. ,
Visualization of plasmid delivery to keratinocytes in mouse and human epidermis, Sci. Rep, vol.1, p.158, 2011. ,
Electro-gene transfer to skin using a noninvasive multielectrode array, J. Control. Release, vol.151, pp.256-262, 2011. ,
DOI : 10.1016/j.jconrel.2011.01.014
URL : http://europepmc.org/articles/pmc3101286?pdf=render
Minimally invasive insulin delivery in subjects with type 1 diabetes using hollow microneedles, Diabetes Technol. Ther, vol.11, issue.6, pp.329-337, 2009. ,
DOI : 10.1089/dia.2008.0103
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779563
Rapid local anesthesia in humans using minimally invasive MNs, Clin. J. Pain, vol.28, issue.2, pp.129-135, 2012. ,
DOI : 10.1097/ajp.0b013e318225dbe9
URL : http://europepmc.org/articles/pmc3200482?pdf=render
Targeted therapy for malignant melanoma, Curr. Opin. Oncol, vol.6, pp.221-225, 1994. ,
Non-viral gene delivery carrier and its three-dimensional transfection system, Int. J. Pharm, vol.386, pp.232-242, 2010. ,
DOI : 10.1016/j.ijpharm.2009.11.006
Cytokine gene expression in epidermis with biological effects following injection of naked DNA, Nat. Genet, vol.10, pp.161-166, 1995. ,
Expression of naked DNA in human, pig, and mouse skin, J. Clin. Invest, vol.97, pp.2911-2916, 1996. ,
Efficient expression of naked plasmid DNA in mucosal epithelium: prospective for the treatment of skin lesions, J. Invest. Dermatol, vol.111, pp.605-608, 1998. ,
Using viral vectors as gene transfer tools (Cell Biology and Toxicology Special Issue: ETCS-UK 1 day meeting on genetic manipulation of cells), Cell Biol. Toxicol, vol.26, issue.1, pp.1-20, 2010. ,
Gene therapy and DNA delivery systems, Int. J. Pharm, vol.459, pp.70-83, 2014. ,
DOI : 10.1016/j.ijpharm.2013.11.041
Enabling skin vaccination using new delivery technologies, Drug Deliv. Transl. Res, vol.1, pp.7-12, 2011. ,
DOI : 10.1007/s13346-010-0005-z
URL : http://europepmc.org/articles/pmc3143039?pdf=render
Cross-protection by coimmunization with influenza hemagglutinin DNA and inactivated virus vaccine using coated microneedles, J. Control. Release, vol.172, issue.2, pp.579-588, 2013. ,
DOI : 10.1016/j.jconrel.2013.04.016
URL : http://europepmc.org/articles/pmc3815987?pdf=render
Polyplex-releasing microneedles for enhanced cutaneous delivery of DNA vaccine, J. Control. Release, vol.10, issue.179, pp.11-17, 2014. ,
High-velocity microprojectiles for delivering nucleic acids into living cells, Nature, vol.327, pp.70-73, 1987. ,
DOI : 10.1038/327070a0
Microneedle-mediated transcutaneous immunization with plasmid DNA coated on cationic PLGA nanoparticles, J. Control. Release, vol.163, issue.2, pp.230-239, 2012. ,
DOI : 10.1016/j.jconrel.2012.08.011
URL : http://europepmc.org/articles/pmc3478475?pdf=render
DNA vaccines: ready for prime time?, Nat. Rev. Genet, vol.9, pp.776-788, 2008. ,
DOI : 10.1038/nrg2432
URL : http://europepmc.org/articles/pmc4317294?pdf=render
Clinical evaluation of a novel microneedle device for intradermal delivery of an influenza vaccine: are all delivery methods the same?, Vaccine, vol.32, issue.34, pp.4249-4252, 2014. ,
Intradermal vaccination using the novel microneedle device MicronJet600: past, present, and future, Hum. Vaccin. Immunother, vol.11, issue.4, pp.991-997, 2015. ,
DOI : 10.1080/21645515.2015.1010871
URL : http://europepmc.org/articles/pmc4514308?pdf=render
Nonviral gene therapy: promises and challenges, Gene Ther, vol.7, issue.1, pp.31-34, 2000. ,
Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA, Gene Ther, vol.6, pp.1258-1266, 1999. ,
Toxicity of cationic lipids and cationic polymers in gene delivery, J. Control. Release, vol.114, issue.1, pp.100-109, 2006. ,
Nucleocytoplasmic transport: the soluble phase, Annu. Rev. Biochem, vol.67, pp.265-306, 1998. ,
DOI : 10.1146/annurev.biochem.67.1.265
URL : http://www.annualreviews.org/doi/pdf/10.1146/annurev.biochem.67.1.265
Microneedles: an innovative platform for gene delivery, Drug Deliv. Transl. Res, vol.5, issue.4, pp.424-437, 2015. ,
Physical methods for intracellular delivery: practical aspects from laboratory use to industrial-scale processing, J. Lab Autom, vol.19, issue.1, pp.1-18, 2014. ,
DOI : 10.1177/2211068213494388
URL : http://journals.sagepub.com/doi/pdf/10.1177/2211068213494388
Improved genetic immunization via micromechanical disruption of skin-barrier function and targeted epidermal delivery, Nat. Med, vol.8, issue.4, pp.415-419, 2002. ,
DOI : 10.1038/nm0402-415
The cost of unsafe injections, Bull. World Health Organ, vol.77, issue.10, pp.808-811, 1999. ,
Immune responses to AAV vectors: overcoming barriers to successful gene therapy, Blood, vol.122, issue.1, pp.23-36, 2013. ,
DOI : 10.1182/blood-2013-01-306647
URL : http://www.bloodjournal.org/content/122/1/23.full.pdf
Cationic lipid-mediated transfection of cells in culture requires mitotic activity, Gene Ther, vol.6, issue.3, pp.403-411, 1999. ,
DOI : 10.1038/sj.gt.3300837
URL : https://www.nature.com/articles/3300837.pdf
Viral and nonviral delivery systems for gene delivery, Adv. Biomed. Res, vol.1, p.27, 2012. ,
Gene therapy progress and prospects: ultrasound for gene transfer, Gene Ther, vol.14, issue.6, pp.465-475, 2007. ,
DOI : 10.1038/sj.gt.3302925
URL : http://www.nature.com/gt/journal/v14/n6/pdf/3302925a.pdf
Development of an ex vivo human skin model for intradermal vaccination: tissue viability and Langerhans cell behavior, Vaccine, vol.27, issue.43, pp.5948-5955, 2009. ,
Liposome-mediated DNA transfer in eukaryotic cells. Dependence of the transfer efficiency upon the type of liposomes used and the host cell cycle stage, Biochim. Biophys. Acta, vol.721, issue.2, pp.185-190, 1982. ,
DOI : 10.1016/0167-4889(82)90067-2
Hollow MNs for intradermal injection fabricated by sacrificial micromolding and selective electrodeposition, Biomed. Microdevices, vol.15, issue.2, pp.203-210, 2013. ,
DOI : 10.1007/s10544-012-9717-9
URL : http://europepmc.org/articles/pmc3572334?pdf=render
Structural characterization and in-vivo reliability evaluation of silicon microneedles, Biomed. Microdevices, vol.16, issue.3, pp.333-343, 2014. ,
DNA vaccines and intradermal vaccination by DNA tattooing, Curr. Top. Microbiol. Immunol, vol.351, pp.221-250, 2012. ,
DOI : 10.1007/82_2010_117
Gene delivery to the epidermal cells of human skin explants using microfabricated microneedles and hydrogel formulations, Pharm. Res, vol.25, issue.2, pp.407-416, 2008. ,
Microneedle delivery of plasmid DNA to living human skin: formulation coating, skin insertion and gene expression, J. Control. Release, vol.160, pp.561-569, 2012. ,
DOI : 10.1016/j.jconrel.2012.04.005
URL : http://europepmc.org/articles/pmc3390019?pdf=render
DNA vaccines: basic mechanism and immune responses (review), Int. J. Mol. Med, vol.4, issue.5, pp.549-555, 1999. ,
DOI : 10.3892/ijmm.4.5.549
Skin electroporation: effects on transgene expression, DNA persistence and local tissue environment, PLoS One, vol.4, issue.9, p.7226, 2009. ,
DOI : 10.1371/journal.pone.0007226
URL : https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0007226&type=printable
Membrane-sealed hollow MNs and related administration schemes for transdermal drug delivery, Biomed. Microdevices, vol.10, pp.271-279, 2008. ,
DOI : 10.1007/s10544-007-9133-8
In vivo gene introduction into keratinocytes using jet injection, Gene Ther, vol.6, pp.1785-1787, 1999. ,
DOI : 10.1038/sj.gt.3301002
URL : https://www.nature.com/articles/3301002.pdf
DNA vaccination in the skin using miocroneedles improves protection against influenza, Mol. Ther, vol.20, issue.7, pp.1472-1480, 2012. ,
DOI : 10.1038/mt.2012.69
URL : https://doi.org/10.1038/mt.2012.69
The nuclear pore complex: from molecular architecture to functional dynamics, Curr. Opin. Cell Biol, vol.11, issue.3, pp.391-401, 1999. ,
Hydrodynamic gene delivery: its principles and applications, Mol. Ther, vol.15, pp.2063-2069, 2007. ,
DOI : 10.1038/sj.mt.6300314
URL : https://doi.org/10.1038/sj.mt.6300314
Structural impact of hydrodynamic injection on mouse liver, Gene Ther, vol.14, pp.129-137, 2007. ,
DOI : 10.1038/sj.gt.3302865
URL : http://www.nature.com/gt/journal/v14/n2/pdf/3302865a.pdf
Progress and problems with the use of viral vectors for gene therapy, Nat. Rev. Genet, vol.4, issue.5, pp.346-358, 2003. ,
Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, doubleblind, Lancet, vol.386, pp.2078-2088, 1008. ,
Safety and efficacy of a novel MN device for dose sparing intradermal influenza vaccination in healthy adults, Vaccine, vol.27, issue.3, pp.454-459, 2009. ,
Iontophoretic delivery of oligonucleotide derivatives into mouse tumor, Antisense Res. Dev, vol.4, pp.291-293, 1996. ,
In vivo gene transfer of naked DNA into xenotransplanted colon carcinoma by jet injection, Langenbeck's Arch. Surg, vol.30, pp.69-72, 2001. ,
Intratumoral low volume jet injection for efficient nonviral gene transfer, Mol. Biotechnol, vol.21, pp.105-115, 2002. ,
DOI : 10.1385/mb:21:2:105
Precise microinjection into skin using hollow microneedles, J. Invest. Dermatol, vol.126, issue.5, pp.1080-1087, 2006. ,
DOI : 10.1038/sj.jid.5700150
URL : https://doi.org/10.1038/sj.jid.5700150
Non-viral gene delivery methods, Curr. Pharm. Biotechnol, vol.14, issue.1, pp.46-60, 2013. ,
A flexible microneedle array as low-voltage electroporation electrodes for in vivo DNA and siRNA delivery, Lab Chip, vol.14, issue.20, pp.4093-4102, 2014. ,
Gene therapy progress and prospects: electroporation and other physical methods, Gene Ther, vol.11, pp.1363-1369, 2004. ,
DOI : 10.1038/sj.gt.3302337
URL : http://www.nature.com/gt/journal/v11/n18/pdf/3302337a.pdf
Efficacy of a peptide-based gene delivery system depends on mitotic activity, Gene Ther, vol.3, issue.12, pp.1133-1142, 1996. ,
Process optimization and characterization of silicon microneedles fabricated by wet etch technology, Microelectronics, vol.36, issue.7, pp.650-656, 2005. ,
DOI : 10.1016/j.mejo.2005.04.044
Nuclear import of plasmid DNA in digitonin-permeabilized cells requires both cytoplasmic factors and specific DNA sequences, J. Biol. Chem, vol.274, issue.31, pp.22025-22032, 1999. ,
Enhancing DNA delivery into the skin with a motorized microneedle device, Eur. J. Pharm. Sci, vol.14, issue.52, pp.215-222, 2014. ,
DOI : 10.1016/j.ejps.2013.11.015
In vivo and in vitro gene transfer to mammalian somatic cells by particle bombardment, Proc. Natl. Acad. Sci. U. S. A, 1990. ,
Topical gene delivery to murine skin, J. Invest. Dermatol, vol.112, pp.370-375, 1999. ,
DOI : 10.1046/j.1523-1747.1999.00513.x
URL : https://doi.org/10.1046/j.1523-1747.1999.00513.x
High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA, Hum. Gene Ther, vol.10, pp.1735-1737, 1999. ,