G. Expression, General procedure: Cells were lysed and tissue samples were homogenised in RLT buffer (Quiagen) Total RNA was isolated with Quiagen RNA extraction kits following the manufacturer's instructions. For real-time PCR analysis, the isolated RNA was reverse transcribed (Eurogentec) For PCR reactions, TaqMan Mastermix (Eurogentec) was used. 50 ng cDNA was used as template to determine the relative amount of mRNA by real-time PCR (BioRad Detection System). PCR conditions were as follows: 95 °C for 10 min followed by 40 cycles of 95 °C for 15 s and 60 °C for 1 min. Data were normalised to 16S mRNA levels. The following primers were used: 16s forward primer, pp.5-8

J. Folkman, Tumor angiogenesis: therapeutic implications. New Engl, J. Med, vol.285, pp.1182-1186, 1971.

D. W. Leung, G. Cachianes, W. J. Kuang, D. V. Goeddel, and N. Ferrara, Vascular endothelial growth factor is a secreted angiogenic mitogen, Science, vol.246, issue.4935, pp.1306-1309, 1989.
DOI : 10.1126/science.2479986

P. Carmeliet and R. K. Jain, Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases, Nature Reviews Drug Discovery, vol.7, issue.6, pp.417-427, 2011.
DOI : 10.1038/nmeth.1475

M. Mazzone, Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization, Cell, vol.136, issue.5, pp.839-851, 2009.
DOI : 10.1016/j.cell.2009.01.020

I. Noguera-troise, Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis, Novartis Found. Symp, vol.283, pp.106-120, 2007.

C. Stockmann, Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis, Nature, vol.126, issue.7223, pp.814-818, 2008.
DOI : 10.1016/S0002-9440(10)63568-7

C. Stockmann, D. Schadendorf, R. Klose, and I. Helfrich, The Impact of the Immune System on Tumor: Angiogenesis and Vascular Remodeling, Frontiers in Oncology, vol.164, issue.10, p.69, 2014.
DOI : 10.4049/jimmunol.164.10.5383

E. Vivier, S. Ugolini, D. Blaise, C. Chabannon, and L. Brossay, Targeting natural killer cells and natural killer T cells in cancer, Nature Reviews Immunology, vol.5, issue.4, pp.239-252, 2012.
DOI : 10.1038/nri1603
URL : https://hal.archives-ouvertes.fr/hal-00685473

J. Hanna, Decidual NK cells regulate key developmental processes at the human fetal-maternal interface, Nature Medicine, vol.4, issue.Suppl. 1, pp.1065-1074, 2006.
DOI : 10.1371/journal.pbio.0040009

W. G. Kaelin and . Jr, The von Hippel???Lindau tumour suppressor protein: O2 sensing and cancer, Nature Reviews Cancer, vol.60, issue.11, pp.865-873, 2008.
DOI : 10.1016/S1535-6108(02)00042-9

C. J. Schofield and P. J. Ratcliffe, Oxygen sensing by HIF hydroxylases, Nature Reviews Molecular Cell Biology, vol.13, issue.5, pp.343-354, 2004.
DOI : 10.1097/01.ASN.0000017223.49823.2A

G. L. Semenza, Hypoxia-Inducible Factors in Physiology and Medicine, Cell, vol.148, issue.3, pp.399-408, 2012.
DOI : 10.1016/j.cell.2012.01.021

V. Nizet and R. S. Johnson, Interdependence of hypoxic and innate immune responses, Nature Reviews Immunology, vol.105, issue.9, pp.609-617, 2009.
DOI : 10.4049/jimmunol.177.8.4962

H. E. Ryan, Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth, Cancer Res, vol.60, pp.4010-4015, 2000.

E. Eckelhart, A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development, Blood, vol.117, issue.5, pp.1565-1573, 2011.
DOI : 10.1182/blood-2010-06-291633

E. Narni-mancinelli, Fate mapping analysis of lymphoid cells expressing the NKp46 cell surface receptor, Proc. Natl. Acad. Sci. USA, pp.18324-18329, 2011.
DOI : 10.1006/dbio.1998.8971
URL : https://hal.archives-ouvertes.fr/hal-00672199

G. Eberl, M. Colonna, D. Santo, J. P. Mckenzie, and A. N. , Innate lymphoid cells: A new paradigm in immunology, Science, vol.15, issue.5, p.6566, 2015.
DOI : 10.1038/ni.2830
URL : https://hal.archives-ouvertes.fr/pasteur-01402704

Y. Hayakawa and M. J. Smyth, CD27 Dissects Mature NK Cells into Two Subsets with Distinct Responsiveness and Migratory Capacity, The Journal of Immunology, vol.176, issue.3, pp.1517-1524, 2006.
DOI : 10.4049/jimmunol.176.3.1517
URL : http://www.jimmunol.org/content/jimmunol/176/3/1517.full.pdf

N. D. Huntington, C. A. Vosshenrich, and J. P. Di-santo, Developmental pathways that generate natural-killer-cell diversity in mice and humans, Nature Reviews Immunology, vol.109, issue.9, pp.703-714, 2007.
DOI : 10.4049/jimmunol.176.4.2053

S. Sarkar, Hypoxia Induced Impairment of NK Cell Cytotoxicity against Multiple Myeloma Can Be Overcome by IL-2 Activation of the NK Cells, PLoS ONE, vol.130, issue.5, p.64835, 2013.
DOI : 10.1371/journal.pone.0064835.s007

D. Gotthardt, STAT5 Is a Key Regulator in NK Cells and Acts as a Molecular Switch from Tumor Surveillance to Tumor Promotion, Cancer Discovery, vol.6, issue.4, pp.414-429, 2016.
DOI : 10.1158/2159-8290.CD-15-0732

J. A. Bertout, S. A. Patel, and M. C. Simon, The impact of O2 availability on human cancer, Nature Reviews Cancer, vol.18, issue.12, pp.967-975, 2008.
DOI : 10.1172/JCI200421086

A. K. Olsson, A. Dimberg, J. Kreuger, and L. Claesson-welsh, VEGF receptor signalling ? in control of vascular function, Nature Reviews Molecular Cell Biology, vol.99, issue.5, pp.359-371, 2006.
DOI : 10.1073/pnas.022017899

R. K. Jain, Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy, Science, vol.307, issue.5706, pp.58-62, 2005.
DOI : 10.1126/science.1104819

R. Klose, Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia, Nature Communications, vol.8, p.12528, 2016.
DOI : 10.1023/A:1008942828960

V. Finisguerra, MET is required for the recruitment of anti-tumoural neutrophils, Nature, vol.14, issue.7556, pp.349-353, 2015.
DOI : 10.1016/j.ccr.2008.08.001

J. Grunstein, W. G. Roberts, O. Mathieu-costello, D. Hanahan, and R. S. Johnson, Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function, Cancer Res, vol.59, pp.1592-1598, 1999.

S. Y. Velasquez, Short Term Hypoxia Synergizes with Interleukin 15 Priming in Driving Glycolytic Gene Transcription and Supports Human Natural Killer Cell Activities, Journal of Biological Chemistry, vol.6, issue.25, pp.12960-12977, 2016.
DOI : 10.1126/scitranslmed.aaa1260

L. Yao, Contribution of natural killer cells to inhibition of angiogenesis by interleukin-12, Blood, vol.93, pp.1612-1621, 1999.

M. J. Smyth, N. Y. Crowe, and D. I. Godfrey, NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma, International Immunology, vol.13, issue.4, pp.459-463, 2001.
DOI : 10.1084/jem.192.5.741

M. J. Smyth, Differential Tumor Surveillance by Natural Killer (Nk) and Nkt Cells, The Journal of Experimental Medicine, vol.163, issue.4, pp.661-668, 2000.
DOI : 10.1002/(SICI)1521-4141(199904)29:04<1390::AID-IMMU1390>3.0.CO;2-C