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The Abl-1 Kinase is Dispensable for NK Cell Inhibitory Signalling and is not Involved in Murine NK Cell Education

Abstract : Natural killer (NK) cell responsiveness in the mouse is determined in an education process guided by inhibitory Ly49 and NKG2A receptors binding to MHC class I molecules. It has been proposed that inhibitory signalling in human NK cells involves Abl-1 (c-Abl)-mediated phosphorylation of Crk, lowering NK cell function via disruption of a signalling complex including C3G and c-Cbl, suggesting that NK cell education might involve c-Abl. Mice deficient in c-Abl expression specifically in murine NK cells displayed normal inhibitory and activating receptor repertoires. Furthermore, c-Abl-deficient NK cells fluxed Ca2+ normally after triggering of ITAM receptors, killed YAC-1 tumour cells efficiently and showed normal, or even slightly elevated, capacity to produce IFN- after activating receptor stimulation. Consistent with these results, c-Abl deficiency in NK cells did not affect NK cell inhibition via the receptors Ly49G2, Ly49A and NKG2A. We conclude that signalling downstream of murine inhibitory receptors does not involve c-Abl and that c-Abl plays no major role in NK cell education in the mouse.
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https://hal-amu.archives-ouvertes.fr/hal-01765091
Contributor : Carine Dou Goarin <>
Submitted on : Thursday, April 12, 2018 - 3:38:42 PM
Last modification on : Wednesday, January 29, 2020 - 11:10:04 AM

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S. Ganesan, T. T. Luu, B. J. Chambers, S. Meinke, P. Brodin, et al.. The Abl-1 Kinase is Dispensable for NK Cell Inhibitory Signalling and is not Involved in Murine NK Cell Education. Scandinavian Journal of Immunology, Wiley, 2017, 86 (3), pp.135-142. ⟨10.1111/sji.12574⟩. ⟨hal-01765091⟩

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