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T Cell Zone Resident Macrophages Silently Dispose of Apoptotic Cells in the Lymph Node

Abstract : In lymph nodes (LNs), dendritic cells (DCs) are thought to dispose of apoptotic cells, a function pertaining to macrophages in other tissues. We found that a population of CX3CR1(+) MERTK+ cells located in the T cell zone of LNs, previously identified as DCs, are efferocytic macrophages. Lineage-tracing experiments and shield chimeras indicated that these T zone macrophages (TZM) are long-lived macrophages seeded in utero and slowly replaced by blood monocytes after birth. Imaging the LNs of mice in which TZM and DCs express different fluorescent proteins revealed that TZM-and not DCs-act as the only professional scavengers, clearing apoptotic cells in the LN T cell zone in a CX3CR1-dependent manner. Furthermore, similar to other macrophages, TZM appear inefficient in priming CD4 T cells. Thus, efferocytosis and T cell activation in the LN are uncoupled processes designated to macrophages and DCs, respectively, with implications to the maintenance of immune homeostasis.
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https://hal-amu.archives-ouvertes.fr/hal-01765096
Contributor : Carine Dou Goarin <>
Submitted on : Thursday, April 12, 2018 - 3:38:52 PM
Last modification on : Wednesday, January 29, 2020 - 11:10:04 AM

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Myriam Baratin, Lea Simon, Audrey Jorquera, Clement Ghigo, Doulaye Dembele, et al.. T Cell Zone Resident Macrophages Silently Dispose of Apoptotic Cells in the Lymph Node. Immunity, Elsevier, 2017, 47 (2), pp.349+. ⟨10.1016/j.immuni.2017.07.019⟩. ⟨hal-01765096⟩

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