Journal articles
Immune checkpoints on innate lymphoid cells
Abstract : In this issue of JEM, Taylor et al. (https://doi.org/10.1084/jem.20161653) describe PD-1 as a critical negative regulator of group 2 innate lymphoid cells (ILC-2s). PD-1 intrinsically controls proliferation and cytokine production of both mouse and human ILC-2s. PD-1 signaling inhibits STAT5 phosphorylation and the removal of this brake by knocking down PD-1 expression or by using anti-PD-1 blocking antibodies, translated in vivo into better clearance of helminth worm infection in mice.
Cited literature [1 references]
https://hal-amu.archives-ouvertes.fr/hal-01765100
Contributor : Carine Dou Goarin Connect in order to contact the contributor
Submitted on : Friday, April 13, 2018 - 11:01:43 AM
Last modification on : Wednesday, November 3, 2021 - 9:38:23 AM
Contributor : Carine Dou Goarin Connect in order to contact the contributor
Submitted on : Friday, April 13, 2018 - 11:01:43 AM
Last modification on : Wednesday, November 3, 2021 - 9:38:23 AM
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