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Immune checkpoints on innate lymphoid cells

Abstract : In this issue of JEM, Taylor et al. (https://doi.org/10.1084/jem.20161653) describe PD-1 as a critical negative regulator of group 2 innate lymphoid cells (ILC-2s). PD-1 intrinsically controls proliferation and cytokine production of both mouse and human ILC-2s. PD-1 signaling inhibits STAT5 phosphorylation and the removal of this brake by knocking down PD-1 expression or by using anti-PD-1 blocking antibodies, translated in vivo into better clearance of helminth worm infection in mice.
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Submitted on : Friday, April 13, 2018 - 11:01:43 AM
Last modification on : Wednesday, January 29, 2020 - 11:10:04 AM

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Laura Chiossone, Eric Vivier. Immune checkpoints on innate lymphoid cells. Journal of Experimental Medicine, Rockefeller University Press, 2017, 214 (6), pp.1561-1563. ⟨10.1084/jem.20170763⟩. ⟨hal-01765100⟩

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