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Optimisation de l'extraction assistée par ultrasons des alcaloïdes bioactifs de Stephania cambodica par la méthodologie des surfaces de réponses

Abstract : Palmatine Roemerine Scanning electron microscopy Tetrahydropalmatine UHPLC Ultrasound a b s t r a c t An ultrasound-assisted extraction (UAE) was optimized for the extraction of three bioac-tive alkaloids, namely, palmatine, roemerine, and tetrahydropalmatine from the tuber of Stephania cambodica. The performance of UAE and microwave-assisted extraction (MAE) was compared with that of percolation. UAE and MAE are also more environmentally friendly and use less toxic chemicals. MAE was as efficient as UAE for the extraction of tetrahydropalmatine; however, UAE significantly enhanced extraction yields of palmatine and roemerine. The influence of effective variables viz. liquidesolid ratio, percentage of ethanol, and time on UAE was then investigated using response surface methodology. The optimal UAE conditions were found to be ethanol 52%, time 9 min, and liquidesolid ratio 26.6:1 mL/g. Structural change was conducted by scanning electron microscopy. These findings suggest that UAE is a practical extractive procedure for preparation of alkaloid-rich extract for pharmacological investigation and for analytical control of S. cambodica tuber.
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Chhavarath Dary, Béatrice Baghdikian, Sothea Kim, Fathi Mabrouki, Sovanmoly Hul, et al.. Optimisation de l'extraction assistée par ultrasons des alcaloïdes bioactifs de Stephania cambodica par la méthodologie des surfaces de réponses. Comptes Rendus Chimie, Elsevier Masson, 2017, 20 (11-12), pp.996-1005. ⟨10.1016/j.crci.2017.09.004⟩. ⟨hal-01765165⟩

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