The role of hyperpolarization-activated cationic current in spike-time precision and intrinsic resonance in cortical neurons in vitro - Archive ouverte HAL Access content directly
Journal Articles The Journal of Physiology Year : 2011

The role of hyperpolarization-activated cationic current in spike-time precision and intrinsic resonance in cortical neurons in vitro

(1, 2) , (3) , (4) , (3) , (3) , (3) , (3) , (3) , (3)
1
2
3
4

Abstract

Hyperpolarization-activated cyclic nucleotide modulated current (I h) sets resonance frequency within the θ-range (5–12 Hz) in pyramidal neurons. However, its precise contribution to the temporal fidelity of spike generation in response to stimulation of excitatory or inhibitory synapses remains unclear. In conditions where pharmacological blockade of I h does not affect synaptic transmission, we show that postsynaptic h-channels improve spike time precision in CA1 pyramidal neurons through two main mechanisms. I h enhances precision of excitatory post-synaptic potential (EPSP)–spike coupling because I h reduces peak EPSP duration. I h improves the precision of rebound spiking following inhibitory postsynaptic potentials (IPSPs) in CA1 pyramidal neurons and sets pacemaker activity in stratum oriens interneurons because I h accelerates the decay of both IPSPs and after-hyperpolarizing potentials (AHPs). The contribution of h-channels to intrinsic resonance and EPSP waveform was comparatively much smaller in CA3 pyramidal neurons. Our results indicate that the elementary mechanisms by which postsynaptic h-channels control fidelity of spike timing at the scale of individual neurons may account for the decreased theta-activity observed in hippocampal and neocortical networks when h-channel activity is pharmacologically reduced.
Fichier principal
Vignette du fichier
Gastrein-Debanne-JPhysiol-2011.pdf (1.34 Mo) Télécharger le fichier
Origin : Publication funded by an institution
Loading...

Dates and versions

hal-01766841 , version 1 (25-04-2018)

Identifiers

Cite

Philippe Gastrein, Emilie Campanac, Célia Gasselin, Robert H. Cudmore, Andrzej Bialowas, et al.. The role of hyperpolarization-activated cationic current in spike-time precision and intrinsic resonance in cortical neurons in vitro. The Journal of Physiology, 2011, 589 (15), pp.3753-3773. ⟨10.1113/jphysiol.2011.209148⟩. ⟨hal-01766841⟩

Collections

CNRS UNIV-AMU
14 View
79 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More