Spike timing-dependent plasticity: a learning rule for dendritic integration in rat CA1 pyramidal neurons - Archive ouverte HAL Access content directly
Journal Articles The Journal of Physiology Year : 2008

Spike timing-dependent plasticity: a learning rule for dendritic integration in rat CA1 pyramidal neurons

(1) , (1)
1

Abstract

Long-term plasticity of dendritic integration is induced in parallel with long-term potentiation (LTP) or depression (LTD) based on presynaptic activity patterns. It is, however, not clear whether synaptic plasticity induced by temporal pairing of pre-and postsynaptic activity is also associated with synergistic modification in dendritic integration. We show here that the spike timing-dependent plasticity (STDP) rule accounts for long-term changes in dendritic integration in CA1 pyramidal neurons in vitro. Positively correlated pre-and postsynaptic activity (delay: +5/+50 ms) induced LTP and facilitated dendritic integration. Negatively correlated activity (delay: −5/−50 ms) induced LTD and depressed dendritic integration. These changes were not observed following positive or negative pairing with long delays (> ±50 ms) or when NMDA receptors were blocked. The amplitude–slope relation of the EPSP was facilitated after LTP and depressed after LTD. These effects could be mimicked by voltage-gated channel blockers, suggesting that the induced changes in EPSP waveform involve the regulation of voltage-gated channel activity. Importantly, amplitude–slope changes induced by STDP were found to be input specific, indicating that the underlying changes in excitability are restricted to a limited portion of the dendrites. We conclude that STDP is a common learning rule for long-term plasticity of both synaptic transmission and dendritic integration, thus constituting a form of functional redundancy that insures significant changes in the neuronal output when synaptic plasticity is induced.
Fichier principal
Vignette du fichier
Campanac-Debanne-JPhysiol-2008.pdf (1.94 Mo) Télécharger le fichier
Origin : Publication funded by an institution
Loading...

Dates and versions

hal-01766849 , version 1 (25-04-2018)

Identifiers

Cite

Emilie Campanac, Dominique Debanne. Spike timing-dependent plasticity: a learning rule for dendritic integration in rat CA1 pyramidal neurons. The Journal of Physiology, 2008, 586 (3), pp.779-793. ⟨10.1113/jphysiol.2007.147017⟩. ⟨hal-01766849⟩

Collections

CNRS UNIV-AMU
22 View
84 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More