Axon Physiology - Aix-Marseille Université Accéder directement au contenu
Article Dans Une Revue Physiological Reviews Année : 2011

Axon Physiology

Résumé

Axons are generally considered as reliable transmission cables in which stable propagation occurs once an action potential is generated. Axon dysfunction occupies a central position in many inherited and acquired neurological disorders that affect both peripheral and central neurons. Recent findings suggest that the functional and computational repertoire of the axon is much richer than traditionally thought. Beyond classical axonal propagation, intrinsic voltage-gated ionic currents together with the geometrical properties of the axon determine several complex operations that not only control signal processing in brain circuits but also neuronal timing and synaptic efficacy. Recent evidence for the implication of these forms of axonal computation in the short-term dynamics of neuronal communication is discussed. Finally, we review how neuronal activity regulates both axon morphology and axonal function on a long-term time scale during development and adulthood.

Domaines

Neurobiologie
Fichier principal
Vignette du fichier
Debanne-Physiol-Rev-2011.pdf (3.35 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-01766861 , version 1 (30-04-2018)

Identifiants

Citer

Dominique Debanne, Emilie Campanac, Andrzej Bialowas, Edmond Carlier, Gisèle Alcaraz. Axon Physiology. Physiological Reviews, 2011, 91 (2), pp.555-602. ⟨10.1152/physrev.00048.2009⟩. ⟨hal-01766861⟩

Collections

CNRS UNIV-AMU MMG
140 Consultations
2533 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More