Skip to Main content Skip to Navigation
Journal articles

What RNAi screens in model organisms revealed about microbicidal response in mammals?

Abstract : The strategies evolved by pathogens to infect hosts and the mechanisms used by the host to eliminate intruders are highly complex. Because several biological pathways and processes are conserved across model organisms, these organisms have been used for many years to elucidate and understand the mechanisms of the host-pathogen relationship and particularly to unravel the molecular processes enacted by the host to kill pathogens. The emergence of RNA interference (RNAi) and the ability to apply it toward studies in model organisms have allowed a breakthrough in the elucidation of host-pathogen interactions. The aim of this mini-review is to highlight and describe recent breakthroughs in the field of host-pathogen interactions using RNAi screens of model organisms. We will focus specifically on the model organisms Drosophila melanogaster, Caenorhabditis elegans, and Danio rerio. Moreover, a recent study examining the immune system of planarian will be discussed.
Document type :
Journal articles
Complete list of metadatas

Cited literature [62 references]  Display  Hide  Download

https://hal-amu.archives-ouvertes.fr/hal-01769534
Contributor : Administrateur Hal Amu <>
Submitted on : Wednesday, April 18, 2018 - 10:30:14 AM
Last modification on : Thursday, April 19, 2018 - 1:23:02 AM

File

fcimb-04-00184.pdf
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Prasad Abnave, Filippo Conti, Cedric Torre, Eric Ghigo. What RNAi screens in model organisms revealed about microbicidal response in mammals?. Frontiers in Cellular and Infection Microbiology, Frontiers Media, 2015, 4, ⟨10.3389/fcimb.2014.00184⟩. ⟨hal-01769534⟩

Share

Metrics

Record views

121

Files downloads

211