A. Aballay, E. Drenkard, L. R. Hilbun, and F. M. Ausubel, Caenorhabditis elegans Innate Immune Response Triggered by Salmonella enterica Requires Intact LPS and Is Mediated by a MAPK Signaling Pathway, Current Biology, vol.13, issue.1, pp.47-52, 2003.
DOI : 10.1016/S0960-9822(02)01396-9

P. Abnave, G. Mottola, G. Gimenez, N. Boucherit, V. Trouplin et al., Screening in Planarians Identifies MORN2 as a Key Component in LC3-Associated Phagocytosis and Resistance to Bacterial Infection, Cell Host & Microbe, vol.16, issue.3, pp.338-350, 2014.
DOI : 10.1016/j.chom.2014.08.002

H. Agaisse, L. S. Burrack, J. A. Philips, E. J. Rubin, N. Perrimon et al., Genome-Wide RNAi Screen for Host Factors Required for Intracellular Bacterial Infection, Science, vol.309, issue.5738, pp.1248-1251, 2005.
DOI : 10.1126/science.1116008

G. Baeg, R. Zhou, and N. Perrimon, Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila, Genes & Development, vol.19, issue.16, pp.1861-1870, 2005.
DOI : 10.1101/gad.1320705

K. Buchmann, Evolution of Innate Immunity: Clues from Invertebrates via Fish to Mammals, Frontiers in Immunology, vol.32, issue.5, 2014.
DOI : 10.1016/S0020-7519(01)00332-0

M. X. Chang, P. Nie, W. , and L. L. , Short and long peptidoglycan recognition proteins (PGRPs) in zebrafish, with findings of multiple PGRP homologs in teleost fish, Molecular Immunology, vol.44, issue.11, pp.3005-3023, 2007.
DOI : 10.1016/j.molimm.2006.12.029

M. X. Chang, Y. P. Wang, and P. Nie, Zebrafish peptidoglycan recognition protein SC (zfPGRP-SC) mediates multiple intracellular signaling pathways, Fish & Shellfish Immunology, vol.26, issue.2, pp.264-274, 2009.
DOI : 10.1016/j.fsi.2008.11.007

URL : http://ir.ihb.ac.cn/bitstream/152342/7818/1/Zebrafish%20peptidoglycan%20recognition%20protein%20SC%20%28zfPGRP-SC%29%20mediates%20multiple%20intracellular%20signaling%20pathways.pdf

S. Cho, K. W. Rogers, F. , and D. S. , The C. elegans Glycopeptide Hormone Receptor Ortholog, FSHR-1, Regulates Germline Differentiation and Survival, Current Biology, vol.17, issue.3, pp.203-212, 2007.
DOI : 10.1016/j.cub.2006.12.027

URL : https://hal.archives-ouvertes.fr/in2p3-00597159

K. Choe, T. Werner, S. Stöven, D. Hultmark, A. et al., Requirement for a Peptidoglycan Recognition Protein (PGRP) in Relish Activation and Antibacterial Immune Responses in Drosophila, Science, vol.296, issue.5566, pp.359-362, 2002.
DOI : 10.1126/science.1070216

H. Clay, J. M. Davis, D. Beery, A. Huttenlocher, S. E. Lyons et al., Dichotomous Role of the Macrophage in Early Mycobacterium marinum Infection of the Zebrafish, Cell Host & Microbe, vol.2, issue.1, pp.29-39, 2007.
DOI : 10.1016/j.chom.2007.06.004

H. Clay, H. E. Volkman, and L. And-ramakrishnan, Tumor Necrosis Factor Signaling Mediates Resistance to Mycobacteria by Inhibiting Bacterial Growth and Macrophage Death, Immunity, vol.29, issue.2, 2008.
DOI : 10.1016/j.immuni.2008.06.011

S. J. Cronin, N. T. Nehme, S. Limmer, S. Liegeois, J. A. Pospisilik et al., Genome-Wide RNAi Screen Identifies Genes Involved in Intestinal Pathogenic Bacterial Infection, Science, vol.456, issue.7219, pp.340-343, 2009.
DOI : 10.1038/nature07383

J. T. Curnutte and B. M. Babior, Biological Defense Mechanisms THE EFFECT OF BACTERIA AND SERUM ON SUPEROXIDE PRODUCTION BY GRANULOCYTES, Journal of Clinical Investigation, vol.53, issue.6, pp.1662-1672, 1974.
DOI : 10.1172/JCI107717

D. Arras, L. Seng, A. Lackford, B. Keikhaee, M. R. Bowerman et al., An Evolutionarily Conserved Innate Immunity Protein Interaction Network, Journal of Biological Chemistry, vol.148, issue.3, 1967.
DOI : 10.3109/13693786.2011.648217

R. Dziarski, Recognition of bacterial peptidoglycan by the innate immune system, Cellular and Molecular Life Sciences (CMLS), vol.60, issue.9, pp.1793-1804, 2003.
DOI : 10.1007/s00018-003-3019-6

S. A. Elliott, S. Alvarado, and A. , The history and enduring contributions of planarians to the study of animal regeneration, Wiley Interdisciplinary Reviews: Developmental Biology, vol.9, issue.10, pp.301-326, 2012.
DOI : 10.1016/j.ydbio.2009.09.015

A. Fire, S. Xu, M. K. Montgomery, S. A. Kostas, S. E. Driver et al., Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans, Nature, vol.48, issue.6669, pp.806-811, 1038.
DOI : 10.1016/S0091-679X(08)61399-0

M. V. Flores, K. C. Crawford, L. M. Pullin, C. J. Hall, K. E. Crosier et al., Dual oxidase in the intestinal epithelium of zebrafish larvae has anti-bacterial properties, Biochemical and Biophysical Research Communications, vol.400, issue.1, pp.164-168, 2010.
DOI : 10.1016/j.bbrc.2010.08.037

E. Foley, O. Farrell, and P. H. , Functional Dissection of an Innate Immune Response by a Genome-Wide RNAi Screen, PLoS Biology, vol.288, issue.8, 2004.
DOI : 10.1371/journal.pbio.0020203.t102

V. Gesellchen, D. Kuttenkeuler, M. Steckel, N. Pelte, and M. Boutros, An RNA interference screen identifies Inhibitor of Apoptosis Protein 2 as a regulator of innate immune signalling in Drosophila, EMBO reports, vol.272, issue.10, pp.979-984, 2005.
DOI : 10.1038/35085597

M. Gottar, V. Gobert, T. Michel, M. Belvin, G. Duyk et al., The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein, Nature, vol.94, issue.6881, pp.640-644, 1038.
DOI : 10.1073/pnas.94.26.14614

URL : https://hal.archives-ouvertes.fr/hal-00311260

M. J. Gravato-nobre, D. Stroud, D. O-'rourke, C. Darby, and J. Hodgkin, Glycosylation Genes Expressed in Seam Cells Determine Complex Surface Properties and Bacterial Adhesion to the Cuticle of Caenorhabditis elegans, Genetics, vol.187, issue.1, pp.141-155, 2011.
DOI : 10.1534/genetics.110.122002

J. Grönholm, M. Kaustio, H. Myllymäki, J. Kallio, J. Saarikettu et al., Not4 enhances JAK/STAT pathway-dependent gene expression in Drosophila and in human cells, The FASEB Journal, vol.118, issue.3, pp.1239-125011, 2012.
DOI : 10.1042/BJ20090500

S. M. Hammond, E. Bernstein, D. Beach, and G. J. Hannon, An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells, Nature, vol.80, issue.6775, pp.293-296, 1038.
DOI : 10.1073/pnas.80.23.7095

R. Hoeven, K. C. Mccallum, M. R. Cruz, and D. A. Garsin, Ce- Duox1/BLI-3 generated reactive oxygen species trigger protective SKN-1 activity via p38 MAPK signaling during infection in C. elegans, PLoS Pathog, 2011.

H. Huang, Z. J. Chen, S. Kunes, G. Chang, and T. Maniatis, Endocytic pathway is required for Drosophila Toll innate immune signaling, Proceedings of the National Academy of Sciences, vol.173, issue.1, pp.8322-8327, 2010.
DOI : 10.1083/jcb.200510123

J. E. Irazoqui, J. M. Urbach, and F. M. Ausubel, Evolution of host innate defence: insights from Caenorhabditis elegans and primitive invertebrates, Nature Reviews Immunology, vol.101, issue.1, pp.47-58, 1038.
DOI : 10.4049/jimmunol.179.5.3109

A. M. Keestra, M. R. De-zoete, L. I. Bouwman, and J. P. Van-putten, Chicken TLR21 Is an Innate CpG DNA Receptor Distinct from Mammalian TLR9, The Journal of Immunology, vol.185, issue.1, pp.460-467, 2010.
DOI : 10.4049/jimmunol.0901921

URL : http://www.jimmunol.org/content/jimmunol/185/1/460.full.pdf

A. A. Kiger, B. Baum, S. Jones, M. R. Jones, A. Coulson et al., A functional genomic analysis of cell morphology using RNA interference, Journal of Biology, vol.2, issue.4, pp.27-37, 2003.
DOI : 10.1186/1475-4924-2-27

A. Kleino, S. Valanne, J. Ulvila, J. Kallio, H. Myllymäki et al., Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway, The EMBO Journal, vol.6, issue.19, pp.3423-3434, 2005.
DOI : 10.1038/sj.emboj.7600807

D. Kuttenkeuler, N. Pelte, A. Ragab, V. Gesellchen, L. Schneider et al., A Large-Scale RNAi Screen Identifies <i>Deaf1 </i>as a Regulator of Innate Immune Responses in <i>Drosophila</i>, Journal of Innate Immunity, vol.2, issue.2, pp.181-194, 1159.
DOI : 10.1159/000248649

X. Li, S. Wang, J. Qi, S. F. Echtenkamp, R. Chatterjee et al., Zebrafish Peptidoglycan Recognition Proteins Are Bactericidal Amidases Essential for Defense against Bacterial Infections, Immunity, vol.27, issue.3, pp.518-529, 2007.
DOI : 10.1016/j.immuni.2007.07.020

L. Lum, S. Yao, B. Mozer, A. Rovescalli, V. Kessler et al., Identification of Hedgehog Pathway Components by RNAi in Drosophila Cultured Cells, Science, vol.299, issue.5615, pp.2039-2045, 2003.
DOI : 10.1126/science.1081403

A. Matsuo, H. Oshiumi, T. Tsujita, H. Mitani, H. Kasai et al., Teleost TLR22 Recognizes RNA Duplex to Induce IFN and Protect Cells from Birnaviruses, The Journal of Immunology, vol.181, issue.5, pp.3474-3485, 2008.
DOI : 10.4049/jimmunol.181.5.3474

A. H. Meijer and H. P. Spaink, Host-Pathogen Interactions Made Transparent with the Zebrafish Model, Current Drug Targets, vol.12, issue.7, pp.1000-1017, 2011.
DOI : 10.2174/138945011795677809

J. A. Melo and G. And-ruvkun, Inactivation of Conserved C.??elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses, Cell, vol.149, issue.2, pp.452-466, 2012.
DOI : 10.1016/j.cell.2012.02.050

M. Morita, Phagocytic response of planarian reticular cells to heat-killed bacteria, Hydrobiologia, vol.17, issue.1, pp.193-199, 1991.
DOI : 10.1007/BF00027602

P. Muller, D. Kuttenkeuler, V. Gesellchen, M. P. Zeidler, and M. Boutros, Identification of JAK/STAT signalling components by genome-wide RNA interference, Nature, vol.3, issue.7052, pp.871-875, 1038.
DOI : 10.1038/nrm909

C. T. Murphy, S. A. Mccarroll, C. I. Bargmann, A. Fraser, R. S. Kamath et al., Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans, Nature, vol.1, issue.6946, pp.277-283, 1038.
DOI : 10.1046/j.1474-9728.2003.00043.x

P. Niethammer, C. Grabher, A. T. Look, T. J. Mitchison, M. Fukuda et al., A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish, Nature, vol.134, issue.7249, pp.996-999, 2003.
DOI : 10.1016/j.bbagen.2008.01.006

N. Paquette, M. Broemer, K. Aggarwal, L. Chen, M. Husson et al., Caspase-Mediated Cleavage, IAP Binding, and Ubiquitination: Linking Three Mechanisms Crucial for Drosophila NF-??B Signaling, Molecular Cell, vol.37, issue.2, pp.172-182, 2010.
DOI : 10.1016/j.molcel.2009.12.036

A. Peltan, L. Briggs, G. Matthews, S. T. Sweeney, and D. F. Smith, Identification of Drosophila Gene Products Required for Phagocytosis of Leishmania donovani, PLoS ONE, vol.9, issue.12, 2012.
DOI : 10.1371/journal.pone.0051831.s010

R. T. Phennicie, M. J. Sullivan, J. T. Singer, J. A. Yoder, K. et al., Specific Resistance to Pseudomonas aeruginosa Infection in Zebrafish Is Mediated by the Cystic Fibrosis Transmembrane Conductance Regulator, Infection and Immunity, vol.78, issue.11, pp.4542-455000302, 2010.
DOI : 10.1128/IAI.00302-10

J. A. Philips, E. J. Rubin, and N. Perrimon, Drosophila RNAi Screen Reveals CD36 Family Member Required for Mycobacterial Infection, Science, vol.309, issue.5738, pp.1251-1253, 2005.
DOI : 10.1126/science.1116006

R. Pukkila-worley, R. Feinbaum, N. V. Kirienko, J. Larkins-ford, A. L. Conery et al., Stimulation of Host Immune Defenses by a Small Molecule Protects C. elegans from Bacterial Infection, PLoS Genetics, vol.4, issue.6, 2012.
DOI : 10.1371/journal.pgen.1002733.s007

A. Ragab, T. Buechling, V. Gesellchen, K. Spirohn, A. Boettcher et al., Ras/MAPK signalling regulates innate immune responses in immune and intestinal stem cells, The EMBO Journal, vol.18, issue.6, pp.1123-1136, 2011.
DOI : 10.1016/j.cellsig.2005.08.020

M. Rämet, The fruit fly Drosophila melanogaster unfolds the secrets of innate immunity, Acta Paediatrica, vol.118, issue.9, pp.900-905, 2012.
DOI : 10.1126/science.1173164

M. Ramet, P. Manfruelli, A. Pearson, B. Mathey-prevot, and R. A. Ezekowitz, Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli, Nature, vol.18, issue.6881, pp.644-648, 1038.
DOI : 10.1093/emboj/18.12.3380

T. Roeder, M. Stanisak, C. Gelhaus, I. Bruchhaus, J. Grötzinger et al., Caenopores are antimicrobial peptides in the nematode Caenorhabditis elegans instrumental in nutrition and immunity, Developmental & Comparative Immunology, vol.34, issue.2, pp.203-209, 2010.
DOI : 10.1016/j.dci.2009.09.010

M. Rosetto, Y. Engström, C. T. Baldari, J. L. Telford, and D. Hultmark, Signals from the IL-1 Receptor Homolog, Toll, Can Activate an Immune Response in a Drosophila Hemocyte Cell Line, Biochemical and Biophysical Research Communications, vol.209, issue.1, pp.111-1161477, 1995.
DOI : 10.1006/bbrc.1995.1477

H. Schulenburg, J. J. Ewbank, L. Kurz, C. Ewbank, and J. J. , The genetics of pathogen avoidance in Caenorhabditis elegans Evolution of the innate immune system: the worm perspective, Mol. Microbiol. Immunol. Rev, vol.66, issue.198, pp.563-570, 2004.

T. Shibata, S. Sekihara, T. Fujikawa, R. Miyaji, K. Maki et al., Transglutaminase-catalyzed protein-protein cross-linking suppresses the activity of the NF-?B-like transcription factor relish, Sci. Signal, 2013.

D. Sieger, C. Stein, D. Neifer, A. M. Van-der-sar, and M. Leptin, The role of gamma interferon in innate immunity in the zebrafish embryo, Disease Models & Mechanisms, vol.2, issue.11-12, pp.571-581, 2009.
DOI : 10.1242/dmm.003509

O. W. Stockhammer, A. Zakrzewska, Z. Hegedûs, H. P. Spaink, and A. H. Meijer, Transcriptome Profiling and Functional Analyses of the Zebrafish Embryonic Innate Immune Response to Salmonella Infection, The Journal of Immunology, vol.182, issue.9, pp.5641-5653, 2009.
DOI : 10.4049/jimmunol.0900082

S. L. Stroschein-stevenson, E. Foley, P. H. O-'farrell, J. , and A. D. , Identification of Drosophila Gene Products Required for Phagocytosis of Candida albicans, PLoS Biology, vol.2, issue.1, 2006.
DOI : 10.1371/journal.pbio.0040004.st002

J. L. Tenor and A. Aballay, A conserved Toll-like receptor is required for Caenorhabditis elegans innate immunity, EMBO reports, vol.25, issue.1, 2008.
DOI : 10.1126/science.290.5489.147

J. H. Thomas, Adaptive evolution in two large families of ubiquitinligase adapters in nematodes and plants, Genome Res, vol.16, 2006.

D. M. Tobin, F. J. Roca, S. F. Oh, R. Mcfarland, T. W. Vickery et al., Host Genotype-Specific Therapies Can Optimize the Inflammatory Response to Mycobacterial Infections, Cell, vol.148, issue.3, pp.434-446, 2012.
DOI : 10.1016/j.cell.2011.12.023

D. M. Tobin, J. C. Vary, J. P. Ray, G. S. Walsh, S. J. Dunstan et al., The lta4h Locus Modulates Susceptibility to Mycobacterial Infection in Zebrafish and Humans, Cell, vol.140, issue.5, pp.717-730, 2010.
DOI : 10.1016/j.cell.2010.02.013

S. Valanne, H. Myllymäki, J. Kallio, M. R. Schmid, A. Kleino et al., Genome-Wide RNA Interference in Drosophila Cells Identifies G Protein-Coupled Receptor Kinase 2 as a Conserved Regulator of NF-??B Signaling, The Journal of Immunology, vol.184, issue.11, pp.6188-6198, 2010.
DOI : 10.4049/jimmunol.1000261

A. M. Van-der-sar, O. W. Stockhammer, C. Van-der-laan, H. P. Spaink, W. Bitter et al., MyD88 Innate Immune Function in a Zebrafish Embryo Infection Model, Infection and Immunity, vol.74, issue.4, pp.2436-2441, 2006.
DOI : 10.1128/IAI.74.4.2436-2441.2006

O. Zugasti, N. Bose, B. Squiban, J. Belougne, C. L. Kurz et al., Activation of a G protein-coupled receptor byits endogenous ligand triggers the innate immune response of Caenorhabditis elegans, Nat. Immunol, 2014.