[Demonstration of a TRH precursor in the pancreas of the newborn rat].

L Ouafik (1) , A. Dutour (1) , P. Giraud (1) , F. Boudouresque (1) , C Castanas (1) , C. Oliver (1)

1 LNE - Laboratoire de Neuroendocrinologie Expérimentale

This study allows the indirect demonstration of a precursor for TRH in pancreatic extracts of 2-days old rats. The sequential treatment of these extracts with trypsin and carboxypeptidase A is followed by a large increase in Pyroglutamyl Histidine Proline (TRH-OH). The molecular weight of the protein that gives rise to TRH-OH after enzymatic treatment ranges between 30,000 and 40,000 daltons. During ontogenesis. TRH levels decrease earlier and more rapidly than that of TRH-precursor levels. These data suggest that changes in the processing of TRH-precursor play a role in the diminution of TRH concentrations that is observed during the first two weeks of life.

Domaines: Cancer

L Ouafik, A. Dutour, P. Giraud, F. Boudouresque, C Castanas, et al.. [Demonstration of a TRH precursor in the pancreas of the newborn rat].. Annales d'Endocrinologie, 1986, pp.43-4. ⟨hal-01769609⟩