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[Demonstration of a TRH precursor in the pancreas of the newborn rat].

Abstract : This study allows the indirect demonstration of a precursor for TRH in pancreatic extracts of 2-days old rats. The sequential treatment of these extracts with trypsin and carboxypeptidase A is followed by a large increase in Pyroglutamyl Histidine Proline (TRH-OH). The molecular weight of the protein that gives rise to TRH-OH after enzymatic treatment ranges between 30,000 and 40,000 daltons. During ontogenesis. TRH levels decrease earlier and more rapidly than that of TRH-precursor levels. These data suggest that changes in the processing of TRH-precursor play a role in the diminution of TRH concentrations that is observed during the first two weeks of life.
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Contributor : L'Houcine Ouafik Connect in order to contact the contributor
Submitted on : Wednesday, April 18, 2018 - 11:08:41 AM
Last modification on : Friday, March 25, 2022 - 2:02:09 PM


  • HAL Id : hal-01769609, version 1
  • PUBMED : 3094424



L Ouafik, A. Dutour, P. Giraud, F. Boudouresque, C Castanas, et al.. [Demonstration of a TRH precursor in the pancreas of the newborn rat].. Annales d'Endocrinologie, 1986, pp.43-4. ⟨hal-01769609⟩



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