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CDA as a predictive marker for life-threatening toxicities in patients with AML treated with cytarabine

Raphaelle Fanciullino 1 Laure Farnault 2 Mélanie Donnette 1 Diane-Charlotte Imbs 1 Catherine Roche 3 Geoffroy Venton 2 Yael Berda-Haddad 3 Vadim Ivanov 3 Joseph Ciccolini 1, 3 L’houcine Ouafik 4, 5 Bruno Lacarelle 1, 3 Régis Costello 2 
1 SMARTc unit - Simulation & Modelling : Adaptive Response for Therapeutics in Cancer
2 Service d’hématologie et de thérapie cellulaire
3 Laboratoire de Biologie médicale, AP-HM
4 CRO2 - Centre de Recherches en Oncologie biologique et Oncopharmacologie
5 Laboratoire de Transfert d'Oncologie Biologique [Hôpital Nord - APHM]
Abstract : Key Points Ara-C is the mainstay of treatment for patients with AML, and life-threatening toxicities are common. We demonstrated that cytidine deaminase downregulation predicts severe/lethal toxicities with cytarabine.
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Submitted on : Wednesday, April 18, 2018 - 3:29:55 PM
Last modification on : Friday, August 5, 2022 - 3:44:07 PM

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Raphaelle Fanciullino, Laure Farnault, Mélanie Donnette, Diane-Charlotte Imbs, Catherine Roche, et al.. CDA as a predictive marker for life-threatening toxicities in patients with AML treated with cytarabine. Blood Advances, 2018, 2 (5), pp.462 - 469. ⟨10.1182/bloodadvances.2017014126⟩. ⟨hal-01770057⟩

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