Dissociations between cognitive and motor effects of psychostimulants and atomoxetine in hyperactive DAT-KO mice

Thomas Del'Guidice , Morgane Lemasson , Adeline Etievant (1) , Stella Manta (2) , Luiz Alexandre V Magno , Guy Escoffier (3) , François Roman (4) , Jean-Martin Beaulieu , Thomas Del’guidice , Luiz Alexandre V. Magno

1 SBRI - Institut cellule souche et cerveau
2 IPMC - Institut de pharmacologie moléculaire et cellulaire
3 NICN - Neurobiologie des interactions cellulaires et neurophysiopathologie - NICN
4 NIA - Neurobiologie intégrative et adaptative

Psychostimulants such as amphetamine and methylphenidate, which target the dopamine transporter (DAT), are the most frequently used drugs for the treatment of hyperactivity and cognitive deficits in humans with attention deficit hyperactivity disorder (ADHD). While psychostimulants can increase activity in healthy subjects, they exert a "paradoxical" calming effect in humans with ADHD as well as in hyperactive mice lacking the dopamine transporter (DAT-KO mice). However, the mechanism of action of these drugs and their impact on cognition in the absence of DAT remain poorly understood.

Domaines: Neurosciences

Thomas Del'Guidice, Morgane Lemasson, Adeline Etievant, Stella Manta, Luiz Alexandre V Magno, et al.. Dissociations between cognitive and motor effects of psychostimulants and atomoxetine in hyperactive DAT-KO mice. Psychopharmacology, 2014, 231 (1), pp.109 - 122. ⟨10.1007/s00213-013-3212-8⟩. ⟨hal-01770083⟩