J. Heeringa, D. A. Van-der-kuip, A. Hofman, J. A. Kors, G. Van-herpen et al., Prevalence, incidence and lifetime risk of atrial fibrillation: the Rotterdam study, European Heart Journal, vol.27, issue.8, pp.949-953, 2006.
DOI : 10.1093/eurheartj/ehi825

M. Haïssaguerre, P. Jaïs, D. C. Shah, A. Takahashi, M. Hocini et al., Spontaneous Initiation of Atrial Fibrillation by Ectopic Beats Originating in the Pulmonary Veins, New England Journal of Medicine, vol.339, issue.10, pp.339-659, 1998.
DOI : 10.1056/NEJM199809033391003

H. Calkins, K. H. Kuck, R. Cappato, J. Brugada, A. J. Camm et al., 2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: Recommendations for Patient Selection, Procedural Techniques, Patient Management and Follow-up, Definitions, Endpoints, and Research Trial Design: A report of the Heart Rhythm Society (HRS) Task Force on Catheter and Surgical Ablation of Atrial Fibrillation. Developed in partnership with the European Heart Rhythm Association (EHRA), a registered branch of the European Society of Cardiology (ESC) and the European Cardiac Arrhythmia Society (ECAS); and in collaboration with the American College of Cardiology (ACC), American Heart Association (AHA), the Asia Pacific Heart Rhythm Society (APHRS), and the Society of Thoracic Surgeons (STS). Endorsed by the governing bodies of the American College of Cardiology Foundation, the American Heart Association, the European Cardiac Arrhythmia Society, the European Heart Rhythm Association, the Society of Thoracic Surgeons, the Asia Pacific Heart Rhythm Society, and the Heart Rhythm Society, Europace, vol.32, issue.2, pp.528-606, 2012.
DOI : 10.1016/j.amjcard.2005.09.063

G. V. Naccarelli, H. Varker, J. Lin, and K. L. Schulman, Increasing Prevalence of Atrial Fibrillation and Flutter in the United States, The American Journal of Cardiology, vol.104, issue.11, pp.1534-1539, 2009.
DOI : 10.1016/j.amjcard.2009.07.022

Y. Kim and S. Roh, The Mechanism of and Preventive Therapy for Stroke in Patients with Atrial Fibrillation, Journal of Stroke, vol.18, issue.2, pp.129-137, 2016.
DOI : 10.5853/jos.2016.00234

O. Morel, F. Toti, B. Hugel, B. Bakouboula, L. Camoin-jau et al., Procoagulant Microparticles: Disrupting the Vascular Homeostasis Equation?, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.26, issue.12, pp.26-2594, 2006.
DOI : 10.1161/01.ATV.0000246775.14471.26

R. Lacroix, C. Dubois, A. S. Leroyer, F. Sabatier, and F. Dignat-george, Revisited role of microparticles in arterial and venous thrombosis, Journal of Thrombosis and Haemostasis, vol.34, issue.Suppl. 2, pp.24-35, 2013.
DOI : 10.1055/s-2008-1079260

L. Drabik, P. Wolkow, and A. Undas, Denser plasma clot formation and impaired fibrinolysis in paroxysmal and persistent atrial fibrillation while on sinus rhythm: Association with thrombin generation, endothelial injury and platelet activation, Thrombosis Research, vol.136, issue.2, pp.136-408, 2015.
DOI : 10.1016/j.thromres.2015.05.028

M. Cattaneo, C. Cerletti, P. Harrison, C. P. Hayward, D. Kenny et al., Recommendations for the standardization of light transmission aggregometry: a consensus of the working party from the platelet physiology subcommittee of SSC/ISTH, Journal of Thrombosis and Haemostasis, vol.106, issue.Suppl. 4, 2013.
DOI : 10.1160/TH11-06-0378

C. Bihour, C. Durrieu-jaïs, L. Macchi, C. Poujol, P. Coste et al., Expression of Markers of Platelet Activation and the Interpatient Variation in Response to Abciximab, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.19, issue.2, pp.212-219, 1999.
DOI : 10.1161/01.ATV.19.2.212

R. Lacroix, C. Judicone, M. Mooberry, M. Boucekine, N. S. Key et al., Standardization of pre-analytical variables in plasma microparticle determination: results of the International Society on Thrombosis and Haemostasis SSC Collaborative workshop, Journal of Thrombosis and Haemostasis, vol.10, issue.6, 2013.
DOI : 10.1111/jth.12012

I. Agouti, S. Cointe, S. Robert, C. Judicone, A. Loundou et al., Platelet and not erythrocyte microparticles are procoagulant in transfused thalassaemia major patients, British Journal of Haematology, vol.89, issue.4, pp.171-615, 2015.
DOI : 10.1038/ki.1996.186

R. Lacroix, L. Plawinski, S. Robert, L. Doeuvre, F. Sabatier et al., Leukocyte- and endothelial-derived microparticles: a circulating source for fibrinolysis, Haematologica, vol.97, issue.12, pp.1864-1872, 2012.
DOI : 10.3324/haematol.2012.066167
URL : https://hal.archives-ouvertes.fr/inserm-00711679

J. G. Akar, W. Jeske, and D. J. Wilber, Acute Onset Human Atrial Fibrillation Is Associated With Local Cardiac Platelet Activation and Endothelial Dysfunction, Journal of the American College of Cardiology, vol.51, issue.18, pp.51-1790, 2008.
DOI : 10.1016/j.jacc.2007.11.083

H. Inoue, T. Nozawa, K. Okumura, L. Jong-dae, A. Shimizu et al., Prothrombotic Activity Is Increased in Patients With Nonvalvular Atrial Fibrillation and Risk Factors for Embolism, Chest, vol.126, issue.3, pp.687-692, 2004.
DOI : 10.1378/chest.126.3.687

V. Roldan, F. Marin, P. Marco, J. G. Martinez, R. Calatayud et al., Hypofibrinolysis in atrial fibrillation, American Heart Journal, vol.136, issue.6, pp.956-960, 1998.
DOI : 10.1016/S0002-8703(98)70149-8

F. Marin, V. Roldan, and G. Y. Lip, Fibrinolytic function and atrial fibrillation, Thrombosis Research, vol.109, issue.5-6, pp.233-240, 2003.
DOI : 10.1016/S0049-3848(03)00259-7

S. R. Coughlin, Protease-activated receptors in hemostasis, thrombosis and vascular biology, Journal of Thrombosis and Haemostasis, vol.77, issue.3, pp.1800-1814, 2005.
DOI : 10.1074/jbc.271.25.14910

A. Achilles, A. Mohring, L. Dannenberg, M. Grandoch, T. Hohlfeld et al., Dabigatran enhances platelet reactivity and platelet thrombin receptor expression in patients with atrial fibrillation, Journal of Thrombosis and Haemostasis, vol.407, issue.3, pp.473-476, 2017.
DOI : 10.1038/35025229

F. Adam, M. Guillin, and M. , Glycoprotein???Ib-mediated platelet activation, European Journal of Biochemistry, vol.258, issue.14, pp.2959-2970, 2003.
DOI : 10.1073/pnas.88.17.7844
URL : http://onlinelibrary.wiley.com/doi/10.1046/j.1432-1033.2003.03670.x/pdf

M. Sebastiano, S. Momi, E. Falcinelli, L. Bury, M. F. Hoylaerts et al., A novel mechanism regulating human platelet activation by MMP-2???mediated PAR1 biased signaling, Blood, vol.129, issue.7, pp.883-895, 2017.
DOI : 10.1182/blood-2016-06-724245

R. C. Becker, Biomarkers in Atrial Fibrillation: Investigating Biologic Plausibility, Cause, and Effect, Journal of Thrombosis and Thrombolysis, vol.55, issue.Suppl, pp.71-75, 2005.
DOI : 10.1161/01.STR.30.12.2547

M. Molino, D. F. Bainton, J. A. Hoxie, S. R. Coughlin, and L. F. Brass, Thrombin receptors on human platelets. Initial localization and subsequent redistribution during platelet activation, J. Biol. Chem, pp.272-6011, 1997.
DOI : 10.1074/jbc.272.9.6011
URL : http://www.jbc.org/content/272/9/6011.full.pdf

M. Schaff, N. Receveur, C. Bourdon, P. Ohlmann, F. Lanza et al., Summary, Thrombosis and Haemostasis, vol.107, issue.04, pp.735-748, 2012.
DOI : 10.1160/TH11-06-0430

D. Li, L. D. Angelo, M. Chavez, and D. S. Woulfe, Arrestin-2 Differentially Regulates PAR4 and ADP Receptor Signaling in Platelets, Journal of Biological Chemistry, vol.104, issue.5, pp.3805-3814, 2011.
DOI : 10.1021/bi052074z

K. Fälker, L. Haglund, P. Gunnarsson, M. Nylander, T. L. Lindahl et al., Protease-activated receptor 1 (PAR1) signalling desensitization is counteracted via PAR4 signalling in human platelets, Biochemical Journal, vol.119, issue.2, pp.436-469, 2011.
DOI : 10.1111/j.1538-7836.2006.01806.x

M. Haissaguerre, A. J. Shah, H. Cochet, M. Hocini, R. Dubois et al., Intermittent drivers anchoring to structural heterogeneities as a major pathophysiological mechanism of human persistent atrial fibrillation, The Journal of Physiology, vol.1, issue.9, pp.594-2387, 2016.
DOI : 10.1016/j.hrcr.2014.10.004

N. Wu, X. Chen, T. Cai, L. Wu, Y. Xiang et al., Association of Inflammatory and Hemostatic Markers With Stroke and Thromboembolic Events in Atrial Fibrillation: A Systematic Review and Meta-analysis, Canadian Journal of Cardiology, vol.31, issue.3, pp.31-278, 2015.
DOI : 10.1016/j.cjca.2014.12.002

S. R. Willoughby, R. L. Roberts-thomson, H. S. Lim, C. Schultz, A. Prabhu et al., Atrial platelet reactivity in patients with atrial fibrillation, Atrial platelet reactivity in patients with atrial fibrillation, pp.1178-1183, 2010.
DOI : 10.1016/j.hrthm.2010.01.042

A. Choudhury, I. Chung, A. D. Blann, and G. Y. Lip, Platelet Surface CD62P and CD63, Mean Platelet Volume, and Soluble/Platelet P-Selectin as Indexes of Platelet Function in Atrial Fibrillation, Journal of the American College of Cardiology, vol.49, issue.19, pp.49-1957, 2007.
DOI : 10.1016/j.jacc.2007.02.038

A. T. Nurden, L. Macchi, C. Bihour, C. Durrieu, P. Besse et al., Markers of platelet activation in coronary heart disease patients, European Journal of Clinical Investigation, vol.17, issue.S1, pp.42-45, 1994.
DOI : 10.1016/0735-1097(91)90943-4

H. S. Lim, S. R. Willoughby, C. Schultz, C. Gan, M. Alasady et al., Effect of Atrial Fibrillation on Atrial Thrombogenesis in Humans: Impact of Rate and Rhythm, Journal of the American College of Cardiology, vol.61, issue.8, pp.61-852, 2013.
DOI : 10.1016/j.jacc.2012.11.046

S. Ederhy, E. Di-angelantonio, Z. Mallat, B. Hugel, S. Janower et al., Levels of Circulating Procoagulant Microparticles in Nonvalvular Atrial Fibrillation, The American Journal of Cardiology, vol.100, issue.6, pp.989-994, 2007.
DOI : 10.1016/j.amjcard.2007.04.040

L. Jesel, T. Arentz, C. Herrera-siklody, D. Trenk, F. Zobairi et al., Do Atrial Differences in Endothelial Damage, Leukocyte and Platelet Activation, or Tissue Factor Activity Contribute to Chamber-Specific Thrombogenic Status in Patients with Atrial Fibrillation?, Journal of Cardiovascular Electrophysiology, vol.19, issue.3, pp.25-266, 2014.
DOI : 10.1016/j.echo.2005.10.013
URL : https://hal.archives-ouvertes.fr/hal-00966562

F. Blasi and P. Carmeliet, uPAR: a versatile signalling orchestrator, Nature Reviews Molecular Cell Biology, vol.190, issue.12, pp.932-943, 2002.
DOI : 10.1002/(SICI)1096-9896(200002)190:3<387::AID-PATH595>3.0.CO;2-R