SacPox from the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius is a proficient lactonase

Janek Bzdrenga (1) , Julien Hiblot (1) , Guillaume Gotthard (1) , Charlotte Champion (1) , Mikael Elias (2) , Eric Chabriere (1)

1 URMITE - Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes
2 Weizmann Institute of Science [Rehovot, Israël]

Background: SacPox, an enzyme from the extremophilic crenarchaeal Sulfolobus acidocaldarius (Sac), was isolated by virtue of its phosphotriesterase (or paraoxonase; Pox) activity, i.e. its ability to hydrolyze the neurotoxic organophosphorus insecticides. Later on, SacPox was shown to belong to the Phosphotriesterase-Like Lactonase family that comprises natural lactonases, possibly involved in quorum sensing, and endowed with promiscuous, phosphotriesterase activity.

Domaines: Biologie cellulaire

Janek Bzdrenga, Julien Hiblot, Guillaume Gotthard, Charlotte Champion, Mikael Elias, et al.. SacPox from the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius is a proficient lactonase. BMC Research Notes, 2014, 7 (1), ⟨10.1186/1756-0500-7-333⟩. ⟨hal-01771510⟩