A. Lowenfels and P. Maisonneuve, Epidemiology and Prevention of Pancreatic Cancer, Japanese Journal of Clinical Oncology, vol.34, issue.5, pp.238-244, 2004.
DOI : 10.1093/jjco/hyh045

A. Jemal, R. Siegel, J. Xu, and W. , Cancer Statistics, 2010, CA: A Cancer Journal for Clinicians, vol.60, issue.5, pp.277-300, 2010.
DOI : 10.3322/caac.20073

I. Fidler, Timeline: The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited, Nature Reviews Cancer, vol.3, issue.6, pp.453-458, 2003.
DOI : 10.1038/nrc1098

M. Kuo and C. Allis, Roles of histone acetyltransferases and deacetylases in gene regulation, BioEssays, vol.15, issue.8, pp.615-626, 1998.
DOI : 10.1016/S0960-9822(98)70040-5

J. Choi, H. Kwon, B. Yoon, J. Kim, and S. Han, Expression Profile of Histone Deacetylase 1 in Gastric Cancer Tissues, Japanese Journal of Cancer Research, vol.60, issue.12, pp.1300-1304, 2001.
DOI : 10.1002/1097-0215(20001215)88:6<992::AID-IJC24>3.0.CO;2-9

P. Zhu, E. Martin, J. Mengwasser, P. Schlag, and K. Janssen, Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis, Cancer Cell, vol.5, issue.5, pp.455-463, 2004.
DOI : 10.1016/S1535-6108(04)00114-X

F. De-nigris, J. Cerutti, C. Morelli, D. Califano, and L. Chiariotti, Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues, British Journal of Cancer, vol.90, issue.2, pp.917-923, 2002.
DOI : 10.1016/S0248-4900(98)80020-8

M. Hiratsuka, T. Inoue, T. Toda, N. Kimura, and Y. Shirayoshi, Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene, Biochemical and Biophysical Research Communications, vol.309, issue.3, pp.558-566, 2003.
DOI : 10.1016/j.bbrc.2003.08.029

P. Fritsche, B. Seidler, S. Schuler, A. Schnieke, and M. Gottlicher, HDAC2 mediates therapeutic resistance of pancreatic cancer cells via the BH3-only protein NOXA, Gut, vol.58, issue.10, pp.1399-1409, 2009.
DOI : 10.1136/gut.2009.180711

A. Aghdassi, M. Sendler, A. Guenther, J. Mayerle, and C. Behn, Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer, Gut, vol.61, issue.3, pp.439-448
DOI : 10.1136/gutjnl-2011-300060

L. Benkoel, J. Bernard, M. Payan-defais, L. Crescence, and C. Franceschi, Monoclonal antibody 16D10 to the COOH-terminal domain of the feto-acinar pancreatic protein targets pancreatic neoplastic tissues, Molecular Cancer Therapeutics, vol.8, issue.2, pp.282-291, 2009.
DOI : 10.1158/1535-7163.MCT-08-0471

M. Ouaissi, I. Sielezneff, R. Silvestre, B. Sastre, and J. Bernard, High Histone Deacetylase 7 (HDAC7) Expression Is Significantly Associated with Adenocarcinomas of the Pancreas, Annals of Surgical Oncology, vol.189, issue.8, pp.2318-2328, 2008.
DOI : 10.1111/j.1349-7006.2001.tb02153.x
URL : https://hal.archives-ouvertes.fr/hal-00374599

C. Frey and G. Smith, Description and Rationale of a New Operation for Chronic Pancreatitis, Pancreas, vol.2, issue.6, pp.701-707, 1987.
DOI : 10.1097/00006676-198711000-00014

A. Nakao, S. Takeda, S. Inoue, S. Nomoto, and N. Kanazumi, Indications and Techniques of Extended Resection for Pancreatic Cancer, World Journal of Surgery, vol.28, issue.6, pp.976-982, 2006.
DOI : 10.1007/s00268-005-0438-6

M. Ouaissi, I. Sielezneff, N. Pirro, A. Merad, and A. Loundou, Pancreatic cancer and pancreaticoduodenectomy in elderly patient: morbidity and mortality are increased. Is it the real life, Hepatogastroenterology, vol.55, pp.2242-2246, 2008.

S. Strasberg and R. Fields, Left-Sided Pancreatic Cancer, The Cancer Journal, vol.18, issue.6, pp.562-570, 2012.
DOI : 10.1097/PPO.0b013e31827596c5

C. Wittekind, C. Compton, F. Greene, and L. Sobin, TNM residual tumor classification revisited, Cancer, vol.4, issue.9, pp.2511-2516, 2002.
DOI : 10.1002/cncr.10492
URL : http://onlinelibrary.wiley.com/doi/10.1002/cncr.10492/pdf

C. Verbeke, D. Leitch, K. Menon, M. Mcmahon, and P. Guillou, Redefining the R1 resection in pancreatic cancer, British Journal of Surgery, vol.72, issue.10, pp.1232-1237, 2006.
DOI : 10.1093/ajcp/111.3.304

J. Luttges, I. Vogel, M. Menke, D. Henne-bruns, and B. Kremer, The retroperitoneal resection margin and vessel involvement are important factors determining survival after pancreaticoduodenectomy for ductal adenocarcinoma of the head of the pancreas, Virchows Archiv, vol.433, issue.3, pp.237-242, 1998.
DOI : 10.1007/s004280050242

W. Fischle, S. Emiliani, M. Hendzel, T. Nagase, and N. Nomura, A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p, J BiolChem, vol.274, pp.11713-11720, 1999.

K. Livak and T. Schmittgen, Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2???????CT Method, Methods, vol.25, issue.4, pp.402-408, 2001.
DOI : 10.1006/meth.2001.1262

M. Ouaissi, U. Giger, I. Sielezneff, N. Pirro, and B. Sastre, Rationale for Possible Targeting of Histone Deacetylase Signaling in Cancer Diseases with a Special Reference to Pancreatic Cancer, Journal of Biomedicine and Biotechnology, vol.7, issue.4, p.315939, 2011.
DOI : 10.1007/s002800100322

J. Bolden, M. Peart, and R. Johnstone, Anticancer activities of histone deacetylase inhibitors, Nature Reviews Drug Discovery, vol.106, issue.9, pp.769-784, 2006.
DOI : 10.4161/cbt.317

R. Frye, Phylogenetic Classification of Prokaryotic and Eukaryotic Sir2-like Proteins, Biochemical and Biophysical Research Communications, vol.273, issue.2, pp.793-798, 2000.
DOI : 10.1006/bbrc.2000.3000

L. Rosenberg, Pancreatic Cancer, Drugs, vol.152, issue.4, pp.1071-1089, 2000.
DOI : 10.2165/00003495-200059050-00004

R. Hruban, M. Goggins, J. Parsons, and S. Kern, Progression model for pancreatic cancer, Clin Cancer Res, vol.6, pp.2969-2972, 2000.

T. Gress, F. Muller-pillasch, M. Geng, F. Zimmerhackl, and G. Zehetner, A pancreatic cancer-specific expression profile, Oncogene, vol.13, pp.1819-1830, 1996.

T. Crnogorac-jurcevic, E. Missiaglia, E. Blaveri, R. Gangeswaran, and M. Jones, Molecular alterations in pancreatic carcinoma: expression profiling shows that dysregulated expression of S100 genes is highly prevalent, The Journal of Pathology, vol.4, issue.1, pp.63-74, 2003.
DOI : 10.1038/nrm808

C. Iacobuzio-donahue, R. Ashfaq, A. Maitra, N. Adsay, and G. Shen-ong, Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies, Cancer Res, vol.63, pp.8614-8622, 2003.

N. Bardeesy and R. Depinho, Pancreatic cancer biology and genetics, Nature Reviews Cancer, vol.2, issue.12, pp.897-909, 2002.
DOI : 10.1038/nrc949

D. Vimalachandran, W. Greenhalf, C. Thompson, J. Luttges, and W. Prime, High Nuclear S100A6 (Calcyclin) Is Significantly Associated with Poor Survival in Pancreatic Cancer Patients, Cancer Research, vol.65, issue.8, pp.3218-3225, 2005.
DOI : 10.1158/0008-5472.CAN-04-4311

M. Fitzgerald, M. Oshiro, N. Holtan, K. Krager, and J. Cullen, Human Pancreatic Carcinoma Cells Activate Maspin Expression Through Loss of Epigenetic Control, Neoplasia, vol.5, issue.5, pp.427-436, 2003.
DOI : 10.1016/S1476-5586(03)80045-3

O. Peulen, A. Gonzalez, P. Peixoto, A. Turtoi, and D. Mottet, The Anti-Tumor Effect of HDAC Inhibition in a Human Pancreas Cancer Model Is Significantly Improved by the Simultaneous Inhibition of Cyclooxygenase 2, PLoS ONE, vol.107, issue.9, p.75102
DOI : 10.1371/journal.pone.0075102.g009

F. Dequiedt, H. Kasler, W. Fischle, V. Kiermer, and M. Weinstein, HDAC7, a Thymus-Specific Class II Histone Deacetylase, Regulates Nur77 Transcription and TCR-Mediated Apoptosis, Immunity, vol.18, issue.5, pp.687-698, 2003.
DOI : 10.1016/S1074-7613(03)00109-2
URL : https://doi.org/10.1016/s1074-7613(03)00109-2

Q. Wu, Y. Li, R. Liu, A. Agadir, and M. Lee, Modulation of retinoic acid sensitivity in lung cancer cells through dynamic balance of orphan receptors nur77 and COUP-TF and their heterodimerization, The EMBO Journal, vol.16, issue.7, pp.1656-1669, 1997.
DOI : 10.1093/emboj/16.7.1656

Y. Li, B. Lin, A. Agadir, R. Liu, and M. Dawson, Molecular Determinants of AHPN (CD437)-Induced Growth Arrest and Apoptosis in Human Lung Cancer Cell Lines, Molecular and Cellular Biology, vol.18, issue.8, pp.4719-4731, 1998.
DOI : 10.1128/MCB.18.8.4719

D. Mottet, A. Bellahcene, S. Pirotte, D. Waltregny, and C. Deroanne, Histone Deacetylase 7 Silencing Alters Endothelial Cell Migration, a Key Step in Angiogenesis, Circulation Research, vol.101, issue.12, pp.1237-1246, 2007.
DOI : 10.1161/CIRCRESAHA.107.149377