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The bacterial pangenome as a new tool for analysing pathogenic bacteria

Abstract : The bacterial pangenome was introduced in 2005 and, in recent years, has been the subject of many studies. Thanks to progress in next-generation sequencing methods, the pangenome can be divided into two parts, the core (common to the studied strains) and the accessory genome, offering a large panel of uses. In this review, we have presented the analysis methods, the pangenome composition and its application as a study of lifestyle. We have also shown that the pangenome may be used as a new tool for redefining the pathogenic species. We applied this to the Escherichia coli and Shigella species, which have been a subject of controversy regarding their taxonomic and pathogenic position. New Microbes and New Infections
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L Rouli, V Merhej, Pierre-Edouard Fournier, Didier Raoult. The bacterial pangenome as a new tool for analysing pathogenic bacteria. New Microbes and New Infections, Wiley Online Library 2015, 7, pp.72-85. ⟨10.1016/j.nmni.2015.06.005⟩. ⟨hal-01772702⟩



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