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Radical Copolymerization of Vinyl Ethers and Cyclic Ketene Acetals as a Versatile Platform to Design Functional Polyesters

Abstract : Free-radical copolymerization of cyclic ketene acetals (CKAs) and vinyl ethers (VEs) was investigated as an efficient yet simple approach for the preparation of functional aliphatic polyesters. The copolymerization of CKA and VE was first predicted to be quasi-ideal by DFT calculations. The theoretical prediction was experimentally confirmed by the copolymerization of 2-methylene-1,3-dioxepane (MDO) and butyl vinyl ether (BVE), leading to r(MDO) = 0.73 and r(BVE) = 1.61. We then illustrated the versatility of this approach by preparing different functional polyesters: 1) copolymers functionalized by fluorescent probes; 2) amphiphilic copolymers grafted with poly(ethylene glycol) (PEG) side chains able to self-assemble into PEGylated nanoparticles; 3) antibacterial films active against Gram-positive and Gram-negative bacteria (including a multiresistant strain); and 4) cross-linked bioelastomers with suitable properties for tissue engineering applications.
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https://hal-amu.archives-ouvertes.fr/hal-01774180
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Submitted on : Monday, April 23, 2018 - 2:41:25 PM
Last modification on : Wednesday, September 16, 2020 - 5:27:55 PM

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Antoine Tardy, Jean-Claude Honore, Johanna Tran, Didier Siri, Vianney Delplace, et al.. Radical Copolymerization of Vinyl Ethers and Cyclic Ketene Acetals as a Versatile Platform to Design Functional Polyesters. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2017, 56 (52), pp.16515--16520. ⟨10.1002/anie.201707043⟩. ⟨hal-01774180⟩

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