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Recent Developments in the Probes and Assays for Measurement of the Activity of NADPH Oxidases

Abstract : NADPH oxidases are a family of enzymes capable of transferring electrons from NADPH to molecular oxygen. A major function of NADPH oxidases is the activation of molecular oxygen into reactive oxygen species. Increased activity of NADPH oxidases has been implicated in various pathologies, including cardiovascular disease, neurological dysfunction, and cancer. Thus, NADPH oxidases have been identified as a viable target for the development of novel therapeutics exhibiting inhibitory effects on NADPH oxidases. Here, we describe the development of new assays for measuring the activity of NADPH oxidases enabling the high-throughput screening for NADPH oxidase inhibitors.
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https://hal-amu.archives-ouvertes.fr/hal-01774183
Contributor : Marlene Delhaye <>
Submitted on : Monday, April 23, 2018 - 2:41:39 PM
Last modification on : Tuesday, April 24, 2018 - 1:30:52 AM

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Jacek Zielonka, Micael Hardy, Radoslaw Michalski, Adam Sikora, Monika Zielonka, et al.. Recent Developments in the Probes and Assays for Measurement of the Activity of NADPH Oxidases. Cell Biochemistry and Biophysics, Humana Press, 2017, 75 (3-4), pp.335--349. ⟨10.1007/s12013-017-0813-6⟩. ⟨hal-01774183⟩

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