Skip to Main content Skip to Navigation
Journal articles

Tracing back ancient oral microbiomes and oral pathogens using dental pulps from ancient teeth

Abstract : Ancient dental pulps are highly precious samples because they conserve DNA from humans and blood-borne pathogens for ages. However, little is known about the microbial communities present in dental pulps. Here, we analyzed ancient and modern dental pulp samples from different time periods and geographic regions and found that they are colonized by distinct microbial communities, which can be differentiated from other oral cavity samples. We found that despite the presence of environmental bacteria, ancient dental pulps conserve a clear and well-conserved record of oral microbes. We were able to detect several different oral pathogens in ancient and modern dental pulps, which are commonly associated with periodontal diseases. We thus showed that ancient dental pulps are not only valuable sources of DNA from humans and systemic infections, but also an open window for the study of ancient oral microbiomes.
Document type :
Journal articles
Complete list of metadata

Cited literature [12 references]  Display  Hide  Download
Contributor : Administrateur HAL AMU Connect in order to contact the contributor
Submitted on : Monday, April 23, 2018 - 4:15:58 PM
Last modification on : Wednesday, June 29, 2022 - 11:45:37 AM
Long-term archiving on: : Wednesday, September 19, 2018 - 2:40:24 AM


Publisher files allowed on an open archive


Distributed under a Creative Commons Attribution 4.0 International License



Nicolas Rascovan, Hong Huynh, Gérard Chouin, Kolawole Adekola, Patrice Georges-Zimmermann, et al.. Tracing back ancient oral microbiomes and oral pathogens using dental pulps from ancient teeth. npj Biofilms and Microbiomes, [London?]: Springer Nature published in partnership with Nanyang Technological University, 2016, 2 (1), ⟨10.1038/s41522-016-0008-8⟩. ⟨hal-01774497⟩



Record views


Files downloads