Increased serum levels of fractalkine and mobilisation of CD34+CD45− endothelial progenitor cells in systemic sclerosis

Audrey Benyamine (1) , Jeremy Magalon (1) , Sylvie Cointe (1) , Romaric Lacroix (1) , Laurent Arnaud (2) , Nathalie Bardin (1) , Pascal Rossi (1) , Yves Frances (3) , Fanny Bernard-Guervilly , Gilles Kaplanski (1) , Jean-Robert Harlé (4) , Pierre-Jean Weiller (5) , Philippe Berbis (6) , David Braunstein , Elisabeth Jouve (7) , Nathalie Lesavre (8) , Françoise Couranjou , Francoise Dignat-George (1) , Florence Sabatier (1) , Pascale Paul (1) , Brigitte Granel (6, 1)

1 VRCM - Vascular research center of Marseille
2 DGCB-LGM - Laboratoire Géomatériaux
3 Service de Médecine Interne
4 Service de Chirurgie
5 Service de Médecine Interne
6 Hôpital Nord [CHU - APHM]
7 TIMONE - Hôpital de la Timone [CHU - APHM]
8 Physiopathologie du stress pancréatique

Background: The disruption of endothelial homeostasis is a major determinant in the pathogenesis of systemic sclerosis (SSc) and is reflected by soluble and cellular markers of activation, injury and repair. We aimed to provide a combined assessment of endothelial markers to delineate specific profiles associated with SSc disease and its severity.

Domaines: Sciences du Vivant [q-bio]; Médecine humaine et pathologie

Audrey Benyamine, Jeremy Magalon, Sylvie Cointe, Romaric Lacroix, Laurent Arnaud, et al.. Increased serum levels of fractalkine and mobilisation of CD34+CD45− endothelial progenitor cells in systemic sclerosis. Arthritis Research and Therapy, 2017, 19 (1), ⟨10.1186/s13075-017-1271-7⟩. ⟨hal-01777909⟩