Identification of CD146 as a novel molecular actor involved in systemic sclerosis

Elise Kaspi (1) , Xavier Heim (2) , Brigitte Granel (3, 2) , Benjamin Guillet (2) , Jimmy Stalin (2) , Marie Nollet (2) , Alexandrine Bertaud-Foucault (2) , Andrée Robaglia-Schlupp (1) , Patrice Roll (4) , Pierre Cau (5) , Aurélie S. Leroyer (2) , Richard Bachelier (2) , Audrey Benyamine (3, 2) , Francoise Dignat-George (2) , Marcel Blot-Chabaud (2) , Nathalie Bardin (2)

1 Laboratoire de Biologie Cellulaire [Hôpital de la Timone - APHM]
2 VRCM - Vascular research center of Marseille
3 Hôpital Nord [CHU - APHM]
4 APHM - Assistance Publique - Hôpitaux de Marseille
5 GMGF - Génétique Médicale et Génomique Fonctionnelle

We highlight for the first time that CD146/sCD146 is involved in fibrotic process during SSc. sCD146 could thus constitute a new biomarker to assess disease activity, and potentially a new target for therapeutic applications.

Keywords: Biomarker; CD146; Disease activity; Systemic sclerosis; Fibrosis; soluble CD146

Domains: Life Sciences [q-bio]; Human health and pathology; Life Sciences [q-bio]; Immunology; Life Sciences [q-bio]

Elise Kaspi, Xavier Heim, Brigitte Granel, Benjamin Guillet, Jimmy Stalin, et al.. Identification of CD146 as a novel molecular actor involved in systemic sclerosis. Journal of Allergy and Clinical Immunology, 2017, 140 (5), pp.1448-1451.e6. ⟨10.1016/j.jaci.2017.04.046⟩. ⟨hal-01778289⟩