Journal articles
Towards a complete structural deciphering of Type VI secretion system
Abstract : The Type VI secretion system (T6SS) is a dynamic nanomachine present in many Gram-negative bacteria. Using a contraction mechanism similar to that of myophages, bacteriocins or anti-feeding prophages, it injects toxic effectors into both eukaryotic and prokaryotic cells. T6SS assembles three large ensembles: the trans-membrane complex (TMC), the baseplate and the tail. Recently, the tail structure has been elucidated by cryo electron microscopy (cryoEM) in extended and contracted forms. The structure of the trans-membrane complex has been deciphered using a combination of X-ray crystallography and EM. However, the structural characterisation of the baseplate lags behind and should be the target of future studies. Finally, cryo-tomography should provide low/medium resolution maps allowing to assemble the different parts ultimately leading to a complete structural description of T6SS.
Cited literature [37 references]
https://hal-amu.archives-ouvertes.fr/hal-01780753
Contributor : Eric Cascales <>
Submitted on : Friday, April 27, 2018 - 6:40:20 PM
Last modification on : Monday, July 12, 2021 - 9:39:07 AM
Long-term archiving on: : Tuesday, September 25, 2018 - 6:35:07 PM
Contributor : Eric Cascales <>
Submitted on : Friday, April 27, 2018 - 6:40:20 PM
Last modification on : Monday, July 12, 2021 - 9:39:07 AM
Long-term archiving on: : Tuesday, September 25, 2018 - 6:35:07 PM
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