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Towards a complete structural deciphering of Type VI secretion system

Abstract : The Type VI secretion system (T6SS) is a dynamic nanomachine present in many Gram-negative bacteria. Using a contraction mechanism similar to that of myophages, bacteriocins or anti-feeding prophages, it injects toxic effectors into both eukaryotic and prokaryotic cells. T6SS assembles three large ensembles: the trans-membrane complex (TMC), the baseplate and the tail. Recently, the tail structure has been elucidated by cryo electron microscopy (cryoEM) in extended and contracted forms. The structure of the trans-membrane complex has been deciphered using a combination of X-ray crystallography and EM. However, the structural characterisation of the baseplate lags behind and should be the target of future studies. Finally, cryo-tomography should provide low/medium resolution maps allowing to assemble the different parts ultimately leading to a complete structural description of T6SS.
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van Son Nguyen, Badreddine Douzi, Eric Durand, Alain Roussel, Eric Cascales, et al.. Towards a complete structural deciphering of Type VI secretion system. Current Opinion in Structural Biology, Elsevier, 2018, 49, pp.77 - 84. ⟨10.1016/j.sbi.2018.01.007⟩. ⟨hal-01780753⟩

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