Bugging out over Chagas: bioluminescent protozoans and old drugs might help unravel kissing-bug disease, Nat. Med, vol.21, pp.1108-1110, 2015. ,
DOI : 10.1038/nm1015-1108
Mother-to-child transmission of congenital Chagas disease, Japan. Emerg. Infect. Dis, vol.20, pp.146-148, 2014. ,
Chronic Chagas disease with advanced cardiac complications in Japan: case report and literature review, Parasitol. Int, vol.64, pp.240-242, 2015. ,
DOI : 10.1016/j.parint.2015.02.005
Chagas disease and the US blood supply, Curr. Opin. Infect. Dis, vol.21, pp.476-482, 2008. ,
DOI : 10.1097/qco.0b013e32830ef5b6
Chagas disease in European countries: the challenge of a surveillance system, Euro. Surveill, vol.16, 2011. ,
Chagas disease: what is known and what is needed-a background article, Mem. Inst. Oswaldo. Cruz, vol.102, pp.113-122, 2007. ,
DOI : 10.1590/s0074-02762007007500001
An update on Chagas disease (human American trypanosomiasis), Ann. Trop. Med. Parasitol, vol.100, pp.663-677, 2006. ,
DOI : 10.1179/136485906x112248
Chagas' heart disease, Clin. Cardiol, vol.23, pp.883-889, 2000. ,
Chagas' disease and Chagas' syndromes: the pathology of American trypanosomiasis, Adv. Parasitol, vol.6, pp.63-116, 1968. ,
Microvascular changes as a cause of chronic cardiomyopathy in Chagas' disease, Am. Heart J, vol.120, pp.233-236, 1990. ,
Role of phosphoinositide 3-kinase in innate immunity, Biol. Pharm. Bull, vol.30, pp.1617-1623, 2007. ,
The phosphoinositide 3-kinase pathway, Science, vol.296, pp.1655-1657, 2002. ,
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism, Nat. Rev. Genet, vol.7, pp.606-619, 2006. ,
Apoptosis-associated speck-like protein containing a caspase recruitment domain inflammasomes mediate IL-1beta response and host resistance to Trypanosoma cruzi infection, J. Immunol, vol.191, pp.3373-3383, 2013. ,
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction, Nature, vol.376, pp.599-602, 1995. ,
Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization, Proc. Natl Acad. Sci. USA, vol.109, pp.9517-9522, 2012. ,
PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and-independent effects, Cell, vol.118, pp.375-387, 2004. ,
Biomarkers of cardiac injury: an update, Angiology, vol.56, pp.677-691, 2005. ,
Cardiac inflammation contributes to changes in the extracellular matrix in patients with heart failure and normal ejection fraction, Circ. Heart Fail, vol.4, pp.44-52, 2011. ,
Diastolic tissue Doppler indexes correlate with the degree of collagen expression and cross-linking in heart failure and normal ejection fraction, J. Am. Coll. Cardiol, vol.57, pp.977-985, 2011. ,
The absence of functional PI3Kgamma prevents leukocyte recruitment and ameliorates DSS-induced colitis in mice, Immunol. Lett, vol.131, pp.33-39, 2010. ,
Loss of phosphoinositide 3-kinase gamma decreases migration and activation of phagocytes but not T cell activation in antigeninduced arthritis, BMC Musculoskelet. Disord, vol.11, p.63, 2010. ,
PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus, Nat. Med, vol.11, pp.933-935, 2005. ,
Phosphoinositide-3 kinase gamma activity contributes to sepsis and organ damage by altering neutrophil recruitment, Am. J. Respir. Crit. Care Med, vol.182, pp.762-773, 2010. ,
Myocardial gene expression of T-bet, GATA-3, Rorgammat, FoxP3, and hallmark cytokines in chronic Chagas disease cardiomyopathy: an essentially unopposed TH1-type response, Mediat. Inflamm, p.914326, 2014. ,
Mode of action of natural and synthetic drugs against Trypanosoma cruzi and their interaction with the mammalian host, Comp. Biochem. Physiol. A Mol. Integr. Physiol, vol.146, pp.601-620, 2007. ,
Differential susceptibilities of mice genomically deleted of CD4 and CD8 to infections with Trypanosoma cruzi or Trypanosoma brucei, Infect. Immun, vol.61, pp.5129-5133, 1993. ,
Predominance of CD8+T lymphocytes in the inflammatory lesions of mice with acute Trypanosoma cruzi infection, Am. J. Trop. Med. Hyg, vol.48, pp.161-169, 1993. ,
Interleukin-12 mediates resistance to Trypanosoma cruziin mice and is produced by murine macrophages in response to live trypomastigotes, Infect. Immun, vol.64, pp.1961-1967, 1996. ,
Susceptibility of beta 2microglobulin-deficient mice to Trypanosoma cruzi infection, Nature, vol.356, pp.338-340, 1992. ,
Nitric oxide is involved in control of Trypanosoma cruzi-induced parasitemia and directly kills the parasite in vitro, Infect. Immun, vol.62, pp.5177-5182, 1994. ,
Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in gamma interferon receptor or inducible nitric oxide synthase, Infect. Immun, vol.66, pp.1208-1215, 1998. ,
Unequal contribution of Akt isoforms in the double-negative to double-positive thymocyte transition, J. Immunol, vol.178, pp.5443-5453, 2007. ,
Activation of host cell phosphatidylinositol 3-kinases by Trypanosoma cruzi infection, J. Biol. Chem, vol.275, pp.32182-32186, 2000. ,
Trypanosoma cruzi: phosphatidylinositol 3-kinase and protein kinase B activation is associated with parasite invasion, Exp. Cell Res, vol.264, pp.211-218, 2001. ,
Trypanosoma cruzi targets Akt in host cells as an intracellular antiapoptotic strategy, Sci. Signal, vol.2, p.74, 2009. ,
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis, Nat. Med, vol.11, pp.936-943, 2005. ,
Phosphoinositide 3-kinase gamma controls inflammation-induced myocardial depression via sequential cAMP and iNOS signalling, Cardiovasc. Res, vol.108, pp.243-253, 2015. ,
Novel insights into the development of chagasic cardiomyopathy: role of PI3Kinase/NO axis, Int. J. Cardiol, vol.167, pp.3011-3020, 2013. ,
PI3Kgamma is a molecular switch that controls immune suppression, Nature, vol.539, pp.437-442, 2016. ,
The role of active myocarditis in the development of heart failure in chronic Chagas' disease: a study based on endomyocardial biopsies, Clin. Cardiol, vol.10, pp.665-670, 1987. ,
Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration, Science, vol.287, pp.1040-1046, 2000. ,
PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and-independent effects, Cell, vol.118, pp.375-387, 2004. ,
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta), Science, vol.292, pp.1728-1731, 2001. ,
Sobre uma cepa de Trypanosoma cruzi altamente virulenta para o camundongo branco, Fol Clin. Biol, vol.20, pp.191-207, 1953. ,
Inhibitor of PI3Kgamma ameliorates TNBS-induced colitis in mice by affecting the functional activity of CD4+CD25+FoxP3+regulatory T cells, Br. J. Pharmacol, vol.163, pp.358-374, 2011. ,
Rapid quantitation of Trypanosoma cruzi in host tissue by real-time PCR, Mol. Biochem. Parasitol, vol.129, pp.53-59, 2003. ,
A method for generation of bone marrow-derived macrophages from cryopreserved mouse bone marrow cells, PLoS ONE, vol.5, p.15263, 2010. ,
Nitric oxide donor trans-[RuCl([15]aneN)NO] as a possible therapeutic approach for Chagas' disease, Br. J. Pharmacol, vol.160, pp.270-282, 2010. ,
The identification of markers of macrophage differentiation in PMAstimulated THP-1 cells and monocyte-derived macrophages, PLoS ONE, vol.5, p.8668, 2010. ,
Nitrate biosynthesis in man, Proc. Natl Acad. Sci. USA, vol.78, pp.7764-7768, 1981. ,
, Br-Fr-Chagas) funded by the French (ANR) and the Brazilian (FAPESP) science funding agencies