R. Young, Control of the Embryonic Stem Cell State, Cell, vol.144, issue.6, pp.940-954, 2011.
DOI : 10.1016/j.cell.2011.01.032

V. Kashyap, N. Rezende, K. Scotland, S. Shaffer, J. Persson et al., Regulation of Stem Cell Pluripotency and Differentiation Involves a Mutual Regulatory Circuit of the Nanog, OCT4, and SOX2 Pluripotency Transcription Factors With Polycomb Repressive Complexes and Stem Cell microRNAs, Stem Cells and Development, vol.18, issue.7, pp.1093-1108, 2009.
DOI : 10.1089/scd.2009.0113

A. Wobus, Potential of embryonic stem cells, Molecular Aspects of Medicine, vol.22, issue.3, pp.149-164, 2001.
DOI : 10.1016/S0098-2997(01)00006-1

A. Wobus and K. Boheler, Embryonic Stem Cells: Prospects for Developmental Biology and Cell Therapy, Physiological Reviews, vol.85, issue.2, pp.635-678, 2005.
DOI : 10.1016/S0248-4900(03)00079-0

URL : http://physrev.physiology.org/content/physrev/85/2/635.full.pdf

A. Wobus, K. Guan, H. Yang, and K. Boheler, Embryonic Stem Cells as a Model to Study Cardiac, Skeletal Muscle, and Vascular Smooth Muscle Cell Differentiation, Methods Mol Biol, vol.185, pp.127-156, 2002.
DOI : 10.1385/1-59259-241-4:127

J. Rohwedel, K. Guan, and A. Wobus, Induction of Cellular Differentiation by Retinoic Acid in vitro, Cells Tissues Organs, vol.165, issue.3-4, pp.190-202, 1999.
DOI : 10.1159/000016699

Q. Ying, M. Stavridis, D. Griffiths, M. Li, and A. Smith, Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture, Nature Biotechnology, vol.128, issue.Suppl., pp.183-186, 2003.
DOI : 10.1073/pnas.95.9.5082

C. Dani, A. Smith, S. Dessolin, P. Leroy, L. Staccini et al., Differentiation of embryonic stem cells into adipocytes in vitro, J Cell Sci, vol.110, pp.1279-1285, 1997.

J. Hescheler, B. Fleischmann, M. Wartenberg, W. Bloch, E. Kolossov et al., Establishment of Ionic Channels and Signalling Cascades in the Embryonic Stem Cell-Derived Primitive Endoderm and Cardiovascular System, Cells Tissues Organs, vol.165, issue.3-4, pp.153-164, 1999.
DOI : 10.1159/000016695

E. Barruet, O. Hadadeh, F. Peiretti, V. Renault, Y. Hadjal et al., p38 Mitogen Activated Protein Kinase Controls Two Successive-Steps During the Early Mesodermal Commitment of Embryonic Stem Cells, Stem Cells and Development, vol.20, issue.7, pp.1233-1246, 2011.
DOI : 10.1089/scd.2010.0213

URL : https://hal.archives-ouvertes.fr/inserm-00532566

A. Cuenda and P. Cohen, Stress-activated Protein Kinase-2/p38 and a Rapamycin-sensitive Pathway Are Required for C2C12 Myogenesis, Journal of Biological Chemistry, vol.15, issue.7, pp.4341-4346, 1999.
DOI : 10.1073/pnas.89.16.7571

URL : http://www.jbc.org/content/274/7/4341.full.pdf

A. Cuenda and S. Rousseau, p38 MAP-Kinases pathway regulation, function and role in human diseases, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1773, issue.8, pp.1358-1375, 2007.
DOI : 10.1016/j.bbamcr.2007.03.010

URL : https://doi.org/10.1016/j.bbamcr.2007.03.010

K. Tamura, T. Sudo, U. Senftleben, A. Dadak, R. Johnson et al., Requirement for p38?? in Erythropoietin Expression, Cell, vol.102, issue.2, pp.221-231, 2000.
DOI : 10.1016/S0092-8674(00)00027-1

R. Adams, A. Porras, G. Alonso, M. Jones, K. Vintersten et al., Essential Role of p38?? MAP Kinase in Placental but Not Embryonic Cardiovascular Development, Molecular Cell, vol.6, issue.1, pp.109-116, 2000.
DOI : 10.1016/S1097-2765(05)00014-6

M. Aouadi, F. Bost, L. Caron, K. Laurent, L. M. Brustel et al., p38 Mitogen-Activated Protein Kinase Activity Commits Embryonic Stem Cells to Either Neurogenesis or Cardiomyogenesis, Stem Cells, vol.87, issue.5, pp.1399-1406, 2006.
DOI : 10.1128/MCB.19.1.21

URL : http://onlinelibrary.wiley.com/doi/10.1634/stemcells.2005-0398/pdf

K. Vousden and C. Prives, Blinded by the Light: The Growing Complexity of p53, Cell, vol.137, issue.3, pp.413-431, 2009.
DOI : 10.1016/j.cell.2009.04.037

T. Lin, C. Chao, S. Saito, S. Mazur, M. Murphy et al., p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression, Nature Cell Biology, vol.66, issue.2, pp.165-171, 2005.
DOI : 10.1093/toxsci/66.2.209

T. Zhao and Y. Xu, p53 and stem cells: new developments and new concerns, Trends in Cell Biology, vol.20, issue.3, pp.170-175, 2010.
DOI : 10.1016/j.tcb.2009.12.004

T. Miyashita, M. Harigai, M. Hanada, and J. Reed, Identification of a p53-dependent negative response element in the bcl-2 gene, Cancer Res, vol.54, pp.3131-3135, 1994.

Y. Wu, J. Mehew, C. Heckman, M. Arcinas, and L. Boxer, Negative regulation of bcl-2 expression by p53 in hematopoietic cells, Oncogene, vol.20, issue.2, pp.240-251, 2001.
DOI : 10.1056/NEJM198701083160204

M. Trouillas, C. Saucourt, D. Duval, X. Gauthereau, C. Thibault et al., Bcl2, a transcriptional target of p38??, is critical for neuronal commitment of mouse embryonic stem cells, Cell Death & Differentiation, vol.25, issue.9, pp.1450-1459, 2008.
DOI : 10.1590/S0001-37652001000300007

URL : https://hal.archives-ouvertes.fr/hal-00315724

P. Komarov, E. Komarova, R. Kondratov, K. Christov-tselkov, J. Coon et al., A Chemical Inhibitor of p53 That Protects Mice from the Side Effects of Cancer Therapy, Science, vol.285, issue.5434, pp.1733-1737, 1999.
DOI : 10.1126/science.285.5434.1733

A. Bondue, G. Lapouge, C. Paulissen, C. Semeraro, M. Iacovino et al., Mesp1 Acts as a Master Regulator of Multipotent Cardiovascular Progenitor Specification, Cell Stem Cell, vol.3, issue.1, pp.69-84, 2008.
DOI : 10.1016/j.stem.2008.06.009

C. Huang, W. Ma, A. Maxiner, Y. Sun, and Z. Dong, p38 Kinase Mediates UV-induced Phosphorylation of p53 Protein at Serine 389, Journal of Biological Chemistry, vol.6, issue.18, pp.12229-12235, 1999.
DOI : 10.1016/S0092-8674(00)80416-X

A. Jain, K. Allton, M. Iacovino, E. Mahen, R. Milczarek et al., p53 Regulates Cell Cycle and MicroRNAs to Promote Differentiation of Human Embryonic Stem Cells, PLoS Biology, vol.128, issue.2, p.1001268, 2012.
DOI : 10.1371/journal.pbio.1001268.s011

V. Solozobova, A. Rolletschek, and C. Blattner, Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damage, BMC Cell Biology, vol.10, issue.1, p.46, 2009.
DOI : 10.1186/1471-2121-10-46

M. Aouadi, K. Laurent, M. Prot, L. Marchand-brustel, Y. Binetruy et al., Inhibition of p38MAPK Increases Adipogenesis From Embryonic to Adult Stages, Diabetes, vol.55, issue.2, pp.281-289
DOI : 10.2337/diabetes.55.02.06.db05-0963

L. Donehower, M. Harvey, B. Slagle, M. Mcarthur, C. Montgomery et al., Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours, Nature, vol.356, issue.6366, pp.215-221, 1992.
DOI : 10.1038/356215a0

URL : http://www.nature.com/nature/journal/v356/n6366/pdf/356215a0.pdf

J. Armstrong, M. Kaufman, D. Harrison, and A. Clarke, High-frequency developmental abnormalities in p53-deficient mice, Current Biology, vol.5, issue.8, pp.931-936, 1995.
DOI : 10.1016/S0960-9822(95)00183-7

URL : https://doi.org/10.1016/s0960-9822(95)00183-7

V. Sah, L. Attardi, G. Mulligan, B. Williams, R. Bronson et al., A subset of p53-deficient embryos exhibit exencephaly, Nature Genetics, vol.15, issue.2, pp.175-180, 1995.
DOI : 10.1083/jcb.119.3.493

N. Almog and V. Rotter, Involvement of p53 in cell differentiation and development, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, vol.1333, issue.1, pp.1-27, 1997.
DOI : 10.1016/S0304-419X(97)00012-7

V. Nikoletopoulou, N. Plachta, N. Allen, L. Pinto, M. Gotz et al., Neurotrophin Receptor-Mediated Death of Misspecified Neurons Generated from Embryonic Stem Cells Lacking Pax6, Cell Stem Cell, vol.1, issue.5, pp.529-540, 2007.
DOI : 10.1016/j.stem.2007.08.011

A. Porrello, M. Cerone, S. Coen, A. Gurtner, G. Fontemaggi et al., P53 Regulates Myogenesis by Triggering the Differentiation Activity of Prb, The Journal of Cell Biology, vol.113, issue.6, pp.1295-1304, 2000.
DOI : 10.1101/gad.827700

A. Molchadsky, I. Shats, N. Goldfinger, M. Pevsner-fischer, M. Olson et al., p53 Plays a Role in Mesenchymal Differentiation Programs, in a Cell Fate Dependent Manner, PLoS ONE, vol.109, issue.11, p.3707, 2008.
DOI : 10.1371/journal.pone.0003707.s002

D. Zhu, L. Qu, X. Zhang, and Y. Lou, Icariin-mediated modulation of cell cycle and p53 during cardiomyocyte differentiation in embryonic stem cells, European Journal of Pharmacology, vol.514, issue.2-3, pp.99-110, 2005.
DOI : 10.1016/j.ejphar.2005.03.031

L. Ding, X. Liang, Y. Hu, D. Zhu, and Y. Lou, Involvement of p38MAPK and Reactive Oxygen Species in Icariin-Induced Cardiomyocyte Differentiation of Murine Embryonic Stem Cells In Vitro, Stem Cells and Development, vol.17, issue.4, pp.751-760, 2008.
DOI : 10.1089/scd.2007.0206

F. Bost, L. Caron, I. Marchetti, C. Dani, L. Marchand-brustel et al., Retinoic acid activation of the ERK pathway is required for embryonic stem cell commitment into the adipocyte lineage, Biochemical Journal, vol.361, issue.3, pp.621-627, 2002.
DOI : 10.1042/bj3610621