Peri-operative oral caffeine does not prevent postoperative atrial fibrillation after heart valve surgery with cardiopulmonary bypass

David Lagier , Laetitia Nee , Régis Guieu (1, 2) , François Kerbaul (1, 2) , Emmanuel Fenouillet (2, 1) , Nicolas Roux (3) , Roch Giorgi (4) , Alexis Theron , Dominique Grisoli , Vlad Gariboldi (1, 2) , Frederic Collart (5) , Nicolas Bruder (6) , Lionel Velly (5) , Catherine Guidon

1 DS-ACI / UMR MD2 - Dysoxie, suractivité : aspects cellulaires et intégratifs thérapeutiques
2 C2VN - Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research
3 TIMONE - Hôpital de la Timone [CHU - APHM]
4 LERTIM - Laboratoire d'Enseignement et de Recherche sur le Traitement de l'Information Médicale
5 APHM - Assistance Publique - Hôpitaux de Marseille
6 Réanimation Polyvalente

BACKGROUND Raised plasma levels of endogenous aden-osine after cardiac surgery using cardiopulmonary bypass (CPB) have been related to the incidence of postoperative atrial fibrillation (POAF). OBJECTIVE We wished to assess if caffeine, an adenosine receptor antagonist could have a beneficial effect on the incidence of POAF. DESIGN A randomised controlled study. SETTING Single University Hospital. PATIENTS One hundred and ten patients scheduled for heart valve surgery with CPB.

Domains: Life Sciences [q-bio]; Life Sciences [q-bio]; Human health and pathology; Life Sciences [q-bio]; Human health and pathology; Cardiology and cardiovascular system

David Lagier, Laetitia Nee, Régis Guieu, François Kerbaul, Emmanuel Fenouillet, et al.. Peri-operative oral caffeine does not prevent postoperative atrial fibrillation after heart valve surgery with cardiopulmonary bypass. European Journal of Anaesthesiology, 2018, ⟨10.1097/EJA.0000000000000824⟩. ⟨hal-01788059⟩