Kv1.2 Channels Promote Nonlinear Spiking Motoneurons for Powering Up Locomotion

Abstract : Graphical Abstract Highlights d Neonatal and adult bistable motoneurons display delayed spike-frequency acceleration d Delayed spike-frequency acceleration reflects slow inactivation of Kv1.2 channels d Kv1.2 channels are highly expressed in axon initial segments of motoneurons d Slow inactivation of Kv1.2 channels amplifies motor outputs upon locomotion onset In Brief Bos et al. demonstrate that slow inactivation of Kv1.2 channels is critical in shaping nonlinear firing properties in mammalian spinal cord. It provides a potent gain control mechanism in spinal motoneurons and has a behavioral role in enhancing locomotor drive during the transition from immobility to steady-state locomotion.