L. Tskhovrebova, J. Trinick, J. A. Sleep, and R. M. Simmons, Elasticity and unfolding of single molecules of the giant muscle protein titin, Nature, vol.387, issue.6630, pp.308-312, 1997.
DOI : 10.1038/387308a0

E. L. Florin, V. T. Moy, and H. E. Gaub, Adhesion forces between individual ligand-receptor pairs, Science, vol.264, issue.5157, pp.415-417, 1994.
DOI : 10.1126/science.8153628

V. T. Moy, E. L. Florin, and H. E. Gaub, Intermolecular forces and energies between ligands and receptors, Science, vol.266, issue.5183, pp.257-259, 1994.
DOI : 10.1126/science.7939660

M. Rief, M. Gautel, F. Oesterhelt, J. M. Fernandez, and H. E. Gaub, Reversible Unfolding of Individual Titin Immunoglobulin Domains by AFM, Science, vol.276, issue.5315, pp.1109-1112, 1997.
DOI : 10.1126/science.276.5315.1109

P. E. Marszalek, H. Lu, H. Li, M. Carrion-vazquez, A. F. Oberhauser et al., Mechanical unfolding intermediates in titin modules, Nature, vol.14, issue.6757, pp.100-103, 1999.
DOI : 10.1016/0263-7855(96)00018-5

P. M. Williams, Analytical descriptions of dynamic force spectroscopy: behaviour of multiple connections, Analytica Chimica Acta, vol.479, issue.1, pp.107-115, 2003.
DOI : 10.1016/S0003-2670(02)01569-6

M. Hinczewski, C. Hyeon, and D. Thirumalai, Directly measuring single-molecule heterogeneity using force spectroscopy, Proceedings of the National Academy of Sciences, vol.5, issue.2, pp.3852-3861, 2016.
DOI : 10.1063/1.371039

URL : http://www.pnas.org/content/113/27/E3852.full.pdf

M. Carrion-vazquez, A. F. Oberhauser, S. B. Fowler, P. E. Marszalek, S. E. Broedel et al., Mechanical and chemical unfolding of a single protein: A comparison, Proceedings of the National Academy of Sciences, vol.280, issue.1, pp.3694-3699, 1999.
DOI : 10.1006/jmbi.1998.1830

F. Rico, L. Gonzalez, I. Casuso, M. Puig-vidal, and S. Scheuring, High-Speed Force Spectroscopy Unfolds Titin at the Velocity of Molecular Dynamics Simulations, Science, vol.422, issue.6930, pp.741-743, 2013.
DOI : 10.1038/nature01517

URL : https://hal.archives-ouvertes.fr/inserm-01309044

M. J. Mould, C. Humphries, . V. Zhu, J. Zarnitsyna, F. Huang et al., 12, Molecular Cell Proceedings of the National Academy of Sciences Biophysical journal, vol.49, issue.882, pp.1060-1068, 2005.

D. A. Radford, . K. Smith-15, M. L. Tych, J. Hughes, Y. Bourke et al., Protein science, Physical Review E Biophysical journal, vol.91, issue.111216, pp.2759-2765, 2002.

D. E. Makarov, P. K. Hansma, and H. Metiu, Kinetic Monte Carlo simulation of titin unfolding, The Journal of Chemical Physics, vol.58, issue.21, pp.9663-9673, 2001.
DOI : 10.1016/S0006-3495(99)77399-6

D. A. Pippig, F. Baumann, M. Strackharn, D. Aschenbrenner, and H. E. Gaub, Protein???DNA Chimeras for Nano Assembly, ACS Nano, vol.8, issue.7, pp.6551-6555, 2014.
DOI : 10.1021/nn501644w

M. Otten, W. Ott, M. A. Jobst, L. F. Milles, T. Verdorfer et al., From genes to protein mechanics on a chip, Nature Methods, vol.82, issue.11, pp.1127-1130, 2014.
DOI : 10.1088/0957-4484/15/9/039

E. Durner, W. Ott, M. A. Nash, and H. E. Gaub, Post-Translational Sortase-Mediated Attachment of High-Strength Force Spectroscopy Handles, ACS Omega, vol.2, issue.6, pp.3064-3069, 2017.
DOI : 10.1021/acsomega.7b00478

K. C. Neuman, T. Lionnet, and J. F. , Single-Molecule Micromanipulation Techniques, Annual Review of Materials Research, vol.37, issue.1, pp.33-67, 2007.
DOI : 10.1146/annurev.matsci.37.052506.084336

E. Celik and V. T. Moy, Nonspecific interactions in AFM force spectroscopy measurements, Journal of Molecular Recognition, vol.21, issue.18, pp.53-56, 2011.
DOI : 10.1007/978-0-387-76497-9_19

Y. Taniguchi and M. Kawakami, Application of HaloTag Protein to Covalent Immobilization of Recombinant Proteins for Single Molecule Force Spectroscopy, Langmuir, vol.26, issue.13, pp.10433-10436, 2010.
DOI : 10.1021/la101658a

J. L. Zimmermann, T. Nicolaus, G. Neuert, and K. Blank, Thiol-based, site-specific and covalent immobilization of biomolecules for single-molecule experiments, Nature Protocols, vol.17, issue.6, pp.975-985, 2010.
DOI : 10.1016/j.febslet.2005.12.052

M. L. Hughes and L. Dougan, The physics of pulling polyproteins: a review of single molecule force spectroscopy using the AFM to study protein unfolding, Reports on Progress in Physics, vol.79, issue.7, p.76601, 2016.
DOI : 10.1088/0034-4885/79/7/076601

J. Yin, A. J. Lin, D. E. Golan, and C. T. Walsh, Site-specific protein labeling by Sfp phosphopantetheinyl transferase, Nature Protocols, vol.105, issue.1, p.280, 2006.
DOI : 10.1016/j.chembiol.2004.02.010

URL : http://www.nature.com/nprot/journal/v1/n1/pdf/nprot.2006.43.pdf

J. L. Hutter and J. Bechhoefer, Calibration of atomic???force microscope tips, Review of Scientific Instruments, vol.2, issue.7, pp.1868-1873, 1993.
DOI : 10.1063/1.107024

H. J. Butt and M. Jaschke, Calculation of thermal noise in atomic force microscopy, Nanotechnology, vol.6, issue.1, pp.1-7, 1995.
DOI : 10.1088/0957-4484/6/1/001

M. Rief, J. M. Fernandez, and H. E. Gaub, Elastically Coupled Two-Level Systems as a Model for Biopolymer Extensibility, Physical Review Letters, vol.72, issue.21, pp.4764-4767, 1998.
DOI : 10.1016/S0006-3495(97)78804-0

Y. Cao, R. Kuske, and H. Li, Direct Observation of Markovian Behavior of the Mechanical Unfolding of Individual Proteins, Biophysical Journal, vol.95, issue.2, pp.782-788, 2008.
DOI : 10.1529/biophysj.107.128298

P. M. Williams, S. B. Fowler, R. B. Best, J. Luis-toca-herrera, K. A. Scott et al., Hidden complexity in the mechanical properties of titin, Proceedings of the National Academy of Sciences of the United States of America, pp.446-449, 2001.
DOI : 10.1016/S0969-2126(96)00036-6

P. Hanggi, P. Talkner, and M. Borkovec, Reaction-rate theory: fifty years after Kramers, Reviews of Modern Physics, vol.35, issue.2, pp.251-341, 1990.
DOI : 10.1103/PhysRevB.35.4737

T. Kuo, S. Garcia-manyes, J. Li, I. Barel, H. Lu et al., Probing static disorder in Arrhenius kinetics by single-molecule force spectroscopy, Proceedings of the National Academy of Sciences, vol.98, issue.2, pp.11336-11340, 2007.
DOI : 10.1073/pnas.98.2.468

URL : http://www.pnas.org/content/107/25/11336.full.pdf

H. Chen, G. Yuan, R. S. Winardhi, M. Yao, I. Popa et al., Dynamics of Equilibrium Folding and Unfolding Transitions of Titin Immunoglobulin Domain under Constant Forces, Journal of the American Chemical Society, vol.137, issue.10, pp.3540-3546, 2015.
DOI : 10.1021/ja5119368

J. Teulon, Y. Delcuze, M. Odorico, S. W. Chen, P. Parot et al., Single and multiple bonds in (strept)avidin-biotin interactions, Journal of Molecular Recognition, vol.125, issue.102, pp.490-502, 2011.
DOI : 10.1063/1.2337629

C. Chu, E. Celik, F. Rico, and V. T. Moy, Elongated Membrane Tethers, Individually Anchored by High Affinity ??4??1/VCAM-1 Complexes, Are the Quantal Units of Monocyte Arrests, PLoS ONE, vol.61, issue.7411, p.64187, 2013.
DOI : 10.1371/journal.pone.0064187.s011

URL : https://hal.archives-ouvertes.fr/inserm-01363143

S. Guo, N. Li, N. Lad, S. Desai, and B. B. Akhremitchev, Distributions of Parameters and Features of Multiple Bond Ruptures in Force Spectroscopy by Atomic Force Microscopy, The Journal of Physical Chemistry C, vol.114, issue.19, pp.8755-8765, 2010.
DOI : 10.1021/jp100543u

E. Evans, Probing the Relation Between Force???Lifetime???and Chemistry in Single Molecular Bonds, Annual Review of Biophysics and Biomolecular Structure, vol.30, issue.1, pp.105-128, 2001.
DOI : 10.1146/annurev.biophys.30.1.105

T. Sulchek, R. W. Friddle, and A. Noy, Strength of Multiple Parallel Biological Bonds, Biophysical Journal, vol.90, issue.12, pp.4686-4691, 2006.
DOI : 10.1529/biophysj.105.080291