Derivation of French biological values for the provision of biological interpretation values for the biomonitoring of occupational exposures - Archive ouverte HAL Access content directly
Journal Articles Toxicologie Analytique et Clinique Year : 2017

Derivation of French biological values for the provision of biological interpretation values for the biomonitoring of occupational exposures

Élaboration des valeurs biologiques françaises en vue de la mise à disposition de valeurs biologiques d’interprétation pour la surveillance biologique des expositions professionnelles

, (1) , , (2) , (3, 4) , (5) ,
1
2
3
4
5

Abstract

Adequate interpretation of biomonitoring results of occupational exposures to chemicals requires comparison values also referred to as biological interpretation values. Among these values are those derived in France by Anses, which are based on a structured approach led collectively by independent and multidisciplinary groups of scientific experts. Two types of occupational biological values are recommended by Anses: biological limit values and biological reference values. These values are derived from the data available in the scientific literature. The article first shows that the derivation by Anses of the biological values to be used for biomonitoring of occupational exposures is linked to the nature of the chemical examined. Depending upon whether the substance is a threshold or non-threshold toxicant, such as genotoxic carcinogens, the approach will be different. Next, some specific examples are presented (cadmium, styrene, 2-butoxyethanol and acrylamide) to help occupational physicians with the informed interpretation of biomonitoring results collected in workplaces. (C) 2017 Societe Francaise de Toxicologie Analytique. Published by Elsevier Masson SAS. All rights reserved.
Pour être interprétés, les résultats de la surveillance biologique des expositions professionnelles aux agents chimiques doivent pouvoir être comparés à des valeurs biologiques d'interprétation. Parmi ces valeurs figurent les valeurs élaborées en France par l'Anses selon une * Auteur correspondant. Adresse
Fichier principal
Vignette du fichier
Sissoko et al.pdf (471.61 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

hal-01794438 , version 1 (17-05-2018)

Identifiers

Cite

Fatoumata Sissoko, Dominique Brunet, Marie-Laure Cointot, Florence Pillière, Anne Maitre, et al.. Élaboration des valeurs biologiques françaises en vue de la mise à disposition de valeurs biologiques d’interprétation pour la surveillance biologique des expositions professionnelles. Toxicologie Analytique et Clinique, 2017, 29 (4), pp.377 - 386. ⟨10.1016/j.toxac.2017.06.004⟩. ⟨hal-01794438⟩
775 View
238 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More