Élaboration des valeurs biologiques françaises en vue de la mise à disposition de valeurs biologiques d’interprétation pour la surveillance biologique des expositions professionnelles

Fatoumata Sissoko; Dominique Brunet; Marie-Laure Cointot; Florence Pillière; Anne Maitre; Irène Sari-Minodier; Claude Viau

doi:10.1016/j.toxac.2017.06.004

Journal articles

Derivation of French biological values for the provision of biological interpretation values for the biomonitoring of occupational exposures

Élaboration des valeurs biologiques françaises en vue de la mise à disposition de valeurs biologiques d’interprétation pour la surveillance biologique des expositions professionnelles

Fatoumata Sissoko Dominique Brunet ¹ Marie-Laure Cointot Florence Pillière ² Anne Maitre ^{3, 4} Irène Sari-Minodier ⁵ Claude Viau

1 DER - Direction de l'Evaluation des Risques

2 Département Études et assistance médicales

3 TIMC-IMAG-EPSP - Environnement et Prédiction de la Santé des Populations

TIMC-IMAG - Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525

4 CHU - Centre Hospitalier Universitaire [Grenoble]

5 Service de Médecine du Travail et des Risques Professionnels

Abstract : Adequate interpretation of biomonitoring results of occupational exposures to chemicals requires comparison values also referred to as biological interpretation values. Among these values are those derived in France by Anses, which are based on a structured approach led collectively by independent and multidisciplinary groups of scientific experts. Two types of occupational biological values are recommended by Anses: biological limit values and biological reference values. These values are derived from the data available in the scientific literature. The article first shows that the derivation by Anses of the biological values to be used for biomonitoring of occupational exposures is linked to the nature of the chemical examined. Depending upon whether the substance is a threshold or non-threshold toxicant, such as genotoxic carcinogens, the approach will be different. Next, some specific examples are presented (cadmium, styrene, 2-butoxyethanol and acrylamide) to help occupational physicians with the informed interpretation of biomonitoring results collected in workplaces. (C) 2017 Societe Francaise de Toxicologie Analytique. Published by Elsevier Masson SAS. All rights reserved.

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Ecology, environment / Health

Environmental Sciences / Environmental and Society

Life Sciences [q-bio] / Santé publique et épidémiologie

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