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Electron Transfer in Catalases and Catalase-Peroxidases

Abstract : Catalases (EC 1.11.1.6) are enzymes that catalyze the disproportionation of hydrogen peroxide into water and molecular oxygen by means of a heme iron or a dimanganese active site. They are crucial metalloproteins regulating the cellular concentration of hydrogen peroxide, which has a concentration-dependent dual role in cell signaling and oxidative stress. Catalase-peroxidases, also named KatGs from the encoding katG gene, are heme-containing oxidoreductases capable of both the disproportionation of hydrogen peroxide and the oxidation of substrates via high-valent heme intermediates. KatGs also generate superoxide via an oxidase reaction and activate the antitubercular prodrug isoniazid (INH) through its conversion to isonicotinyl-NAD.
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Submitted on : Wednesday, May 23, 2018 - 11:52:59 AM
Last modification on : Saturday, February 26, 2022 - 3:13:37 AM

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Anabella Ivancich, Peter C. Loewen. Electron Transfer in Catalases and Catalase-Peroxidases. Encyclopedia of Biophysics, 2018, 978-3-642-35943-9. ⟨10.1007/978-3-642-35943-9_51-1⟩. ⟨hal-01798212⟩

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