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Book Sections Year : 2018

Electron Transfer in Catalases and Catalase-Peroxidases

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Abstract

Catalases (EC 1.11.1.6) are enzymes that catalyze the disproportionation of hydrogen peroxide into water and molecular oxygen by means of a heme iron or a dimanganese active site. They are crucial metalloproteins regulating the cellular concentration of hydrogen peroxide, which has a concentration-dependent dual role in cell signaling and oxidative stress. Catalase-peroxidases, also named KatGs from the encoding katG gene, are heme-containing oxidoreductases capable of both the disproportionation of hydrogen peroxide and the oxidation of substrates via high-valent heme intermediates. KatGs also generate superoxide via an oxidase reaction and activate the antitubercular prodrug isoniazid (INH) through its conversion to isonicotinyl-NAD.
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Anabella Ivancich, Peter C. Loewen. Electron Transfer in Catalases and Catalase-Peroxidases. Encyclopedia of Biophysics, , 2018, 978-3-642-35943-9. ⟨10.1007/978-3-642-35943-9_51-1⟩. ⟨hal-01798212⟩

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