Interactome maps of mouse gene regulatory domains 683 reveal basic principles of transcriptional regulation, Cell, vol.155, pp.1507-1520, 2013. ,
Mapping long-range promoter contacts in human cells with high685 resolution capture Hi-C, Nature genetics, vol.47, pp.598-606, 2015. ,
The pluripotent regulatory circuitry connecting promoters 687 to their long-range interacting elements, Genome research, vol.25, pp.582-597, 2015. ,
Lineage-Specific Genome Architecture Links Enhancers and 689, 2016. ,
DOI : 10.1016/j.cell.2016.09.037
URL : https://doi.org/10.1016/j.cell.2016.09.037
, Non-coding Disease Variants to Target Gene Promoters, Cell, vol.167, p.1319
Enhancer connectome in primary human cells identifies 691 target genes of disease-associated DNA elements, Nature genetics, vol.49, pp.1602-1612, 2017. ,
Integrating epigenomic data and 3D genomic structure with a 693 new measure of chromatin assortativity, Genome Biol, vol.17, p.152, 2016. ,
Recent advances in high-throughput approaches to 695 dissect enhancer function, vol.6, p.939, 1000. ,
Genome-wide quantitative enhancer activity maps identified 697 by STARR-seq, Science, vol.339, pp.1074-1077, 2013. ,
DOI : 10.1126/science.1232542
Enhancer-core-promoter specificity separates developmental 699 and housekeeping gene regulation, Nature, vol.518, pp.556-559, 2015. ,
DOI : 10.1038/nature13994
High-throughput functional comparison of promoter and 701 enhancer activities, Genome research, vol.26, pp.1023-1033, 2016. ,
Genome-wide characterization of mammalian promoters with 703 distal enhancer functions, Nature genetics, vol.49, pp.1073-1081, 2017. ,
Functional assessment of human enhancer activities using whole705 genome STARR-sequencing, Genome Biol, vol.18, p.219, 2017. ,
Resolving systematic errors in widely used enhancer activity 707 assays in human cells, Nat Methods, vol.15, pp.141-149, 2018. ,
Functional dissection of the enhancer repertoire in human 709 embryonic stem cells, 2017. ,
High-resolution genome-wide functional dissection of 711 transcriptional regulatory regions in human, p.712, 2017. ,
Genome-scale high-resolution mapping of activating and repressive 713 nucleotides in regulatory regions, Nat Biotechnol, vol.34, pp.1180-1190, 2016. ,
Massively parallel cis-regulatory analysis in the mammalian 715 central nervous system, Genome research, vol.26, pp.238-255, 2016. ,
FIREWACh: high-throughput functional detection of 717 transcriptional regulatory modules in mammalian cells, Nat Methods, vol.11, pp.559-565, 2014. ,
A systematic comparison reveals substantial differences in 719 chromosomal versus episomal encoding of enhancer activity, Genome research, vol.27, pp.38-52, 2017. ,
Intragenic enhancers act as alternative promoters, Molecular cell, vol.721, pp.447-458, 2012. ,
DOI : 10.1016/j.molcel.2011.12.021
URL : https://doi.org/10.1016/j.molcel.2011.12.021
High-Throughput Approaches to Pinpoint Function within 723 the Noncoding Genome, Molecular cell, vol.68, pp.44-59, 2017. ,
Genetic and epigenetic control of gene expression by CRISPR725 Cas systems, vol.6, 1000. ,
Local regulation of gene expression by lncRNA promoters, 727 transcription and splicing, Nature, 2016. ,
Unlinking an lncRNA from Its Associated cis Element, Molecular cell, vol.729, pp.104-110, 2016. ,
DOI : 10.1016/j.molcel.2016.02.029
URL : https://doi.org/10.1016/j.molcel.2016.02.029
A tiling-deletion-based genetic screen for cis-regulatory element 731 identification in mammalian cells, Nat Methods, vol.14, pp.629-635, 2017. ,
High-throughput mapping of regulatory DNA, Nat Biotechnol, vol.733, pp.167-174, 2016. ,
Clustering of Drosophila housekeeping promoters facilitates 735 their expression, Genome research, vol.27, pp.1153-1161, 2017. ,
Genomic approaches towards finding cis-regulatory 737 modules in animals, Nature reviews. Genetics, vol.13, pp.469-483, 2012. ,
The degree of enhancer or promoter activity is reflected 739 by the levels and directionality of eRNA transcription, Genes Dev, vol.32, pp.42-57, 2018. ,
Bidirectional Transcription Arises from Two Distinct Hubs of 741, 2015. ,
, Transcription Factor Binding and Active Chromatin. Molecular cell, vol.58, pp.1101-1112
Integrative analysis of haplotype-resolved epigenomes across 743 human tissues, Nature, vol.518, pp.350-354, 2015. ,
Enhancer-promoter interactions are encoded by complex 745 genomic signatures on looping chromatin, Nature genetics, vol.48, pp.488-496, 2016. ,
DOI : 10.1038/ng.3539
URL : http://europepmc.org/articles/pmc4910881?pdf=render
YY1 Is a Structural Regulator of Enhancer-Promoter 747, 2017. ,
, Loops. Cell, vol.171, p.1528
Transcription factories, vol.3, p.221, 2012. ,
Why the activity of a gene depends on its neighbors, Trends in genetics : TIG, vol.750, pp.483-490, 2015. ,
Active RNA polymerases: mobile or immobile molecular 752 machines?, PLoS biology, vol.8, p.1000419, 2010. ,
DOI : 10.1371/journal.pbio.1000419
URL : https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1000419&type=printable
Chromosomal contact permits transcription between 754 coregulated genes, Cell, vol.155, pp.606-620, 2013. ,
DOI : 10.1016/j.cell.2013.09.051
URL : https://doi.org/10.1016/j.cell.2013.09.051
A Phase Separation Model for Transcriptional Control, Cell, vol.169, pp.13-23, 2017. ,
Genome-wide mapping of promoter-anchored interactions with 758 close to single-enhancer resolution, Genome Biol, vol.16, p.156, 2015. ,
Constructing 3D interaction maps from 1D epigenomes, vol.7, p.10812, 2016. ,
DOI : 10.1038/ncomms10812
URL : https://www.nature.com/articles/ncomms10812.pdf
Active and poised promoter states drive folding of the extended 762, 2017. ,
, HoxB locus in mouse embryonic stem cells, Nature structural & molecular biology, vol.24, p.524
Cohesin: a global player in chromosome biology with local 765 ties to gene regulation, Curr Opin Genet Dev, vol.20, pp.555-561, 2010. ,
The new NHGRI-EBI Catalog of published genome-wide 767 association studies (GWAS Catalog), Nucleic acids research, vol.45, pp.896-901, 2017. ,
Systematic localization of common disease-associated 769 variation in regulatory DNA, Science, vol.337, pp.1190-1195, 2012. ,
The Genetics of Transcription Factor DNA Binding 771 Variation, Cell, vol.166, pp.538-554, 2016. ,
FTO Obesity Variant Circuitry and Adipocyte Browning in 773, 2015. ,
, Humans. The New England journal of medicine, vol.373, pp.895-907
A Genetic Variant Associated with Five Vascular Diseases Is a 775, 2017. ,
, Distal Regulator of Endothelin-1 Gene Expression. Cell, vol.170, p.515
Genetic effects on gene expression across human tissues, Nature, vol.777, pp.204-213, 2017. ,
A common functional regulatory variant at a type 2 diabetes 779 locus upregulates ARAP1 expression in the pancreatic beta cell, Am J Hum Genet, vol.94, pp.186-780, 2014. ,
Genome-wide association analysis and fine mapping of 782 NT-proBNP level provide novel insight into the role of the MTHFR-CLCN6-NPPA-NPPB 783 gene cluster, Hum Mol Genet, vol.20, pp.1660-1671, 2011. ,
Association of genetic variation in the natriuretic peptide system 785 with cardiovascular outcomes, Journal of molecular and cellular cardiology, vol.50, pp.695-701, 2011. ,
Natriuretic peptide system gene variants are associated with 787 ventricular dysfunction after coronary artery bypass grafting, Anesthesiology, vol.110, pp.738-747, 2009. ,
Identification of a regulatory domain controlling the Nppa789, 2016. ,
, Nppb gene cluster during heart development and stress, Development, vol.143, pp.2135-2146
, Transcriptional Addiction in Cancer. Cell, vol.168, pp.629-643, 2017.
Enhancer biology and enhanceropathies, Nature 792 structural & molecular biology, vol.21, pp.210-219, 2014. ,
DOI : 10.1038/nsmb.2784
Cornelia de Lange syndrome, Clin Genet, vol.88, pp.1-12, 2015. ,
Connected Gene Communities Underlie Transcriptional 795 Changes in Cornelia de Lange Syndrome, Genetics, vol.207, pp.139-151, 2017. ,
STARR-seq-Principles and applications, Genomics, vol.797, 2015. ,
BCL11A enhancer dissection by Cas9-mediated in situ 798 saturating mutagenesis, Nature, vol.527, pp.192-197, 2015. ,
In vivo sequence requirements of the SV40 early 800 promotor region, Nature, vol.290, pp.304-310, 1981. ,
A very strong enhancer is located upstream of an immediate 802 early gene of human cytomegalovirus, Cell, vol.41, pp.521-530, 1985. ,
Heat shock regulatory elements function as an 804 inducible enhancer in the Xenopus hsp70 gene and when linked to a heterologous promoter, 805 Cell, vol.45, pp.753-760, 1986. ,
Identification of a transcriptional enhancer element upstream 807 from the proto-oncogene fos, Science, vol.230, pp.1174-1177, 1985. ,
Metal-dependent SV40 viruses containing inducible enhancers 809 from the upstream region of metallothionein genes, The EMBO journal, vol.4, pp.3851-3859, 1985. ,
Delimitation of far upstream sequences 811 required for maximal in vitro transcription of an H2A histone gene, Proc Natl Acad Sci U S A, vol.812, issue.79, pp.297-301, 1982. ,