Mutation analysis of BRAF exon 15 and KRAS codons 12 and 13 in Moroccan patients with colorectal cancer.

Bahia Bennani (1) , Sophie Gilles (2) , Frederic Fina (2) , Isabelle Nanni (2) , Sidi Adil Ibrahimi (1) , Afaf Amarti Riffi (1) , Chakib Nejjari (1) , Dafr-Allah Benajeh (1) , Mohammed El Abkari (1) , Pierre-Marie Martin (2) , L'Houcine Ouafik (2)

1 Faculté de Médecine et de Pharmacie de Fès
2 Laboratoire de Transfert d'Oncologie Biologique [Hôpital Nord - APHM]

The RAS/RAF/MEK/MAP kinase cascade transduces signals from the cell surface to the nucleus in order to control cellular responses including proliferation, differentiation and survival. We investigated the occurrence of BRAF exon 15 and KRAS codon 12 and 13 mutations in Moroccan patients with colorectal cancer.

Domaines: Cancer

Bahia Bennani, Sophie Gilles, Frederic Fina, Isabelle Nanni, Sidi Adil Ibrahimi, et al.. Mutation analysis of BRAF exon 15 and KRAS codons 12 and 13 in Moroccan patients with colorectal cancer.. international Journal of Biological Markers, 2010, pp.179-84. ⟨hal-01827638⟩