J. M. Blair, M. A. Webber, A. J. Baylay, D. O. Ogbolu, and L. J. Piddock, Molecular mechanisms of antibiotic resistance, Nat Rev Microbiol, vol.13, pp.42-51, 2015.

A. Davin-regli, J. M. Bolla, C. E. James, J. P. Lavigne, and C. J. , Membrane permeability and regulation of drug "influx and efflux" in Enterobacterial pathogens, Curr Drug Targets, vol.9, pp.750-759, 2008.

A. Davin-regli and J. M. Pagès, Enterobacter aerogenes and Enterobacter cloacae: versatile bacterial pathogens confronting antibiotic treatment, Front. Microbiol, vol.6, p.392, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01211462

R. P. Vonberg, A. Wolter, A. Kola, S. Ziesing, and P. Gastmeier, The endemic situation of Enterobacter aerogenes and Enterobacter cloacae: you will only discover what you are looking for, J Hosp Infect, vol.65, pp.372-374, 2007.

S. M. Diene, V. Merhej, M. Henry, E. Filali, A. Roux et al., The rhizome of the multidrug-resistant Enterobacter aerogenes genome reveals how new "killer bugs" are created because of a sympatric lifestyle, Mol Biol Evol, vol.30, pp.369-83, 2013.

C. Bornet, A. Davin-régli, C. Bosi, J. M. Pages, and C. Bollet, Imipenem resistance of Enterobacter aerogenes mediated by outer membrane permeability, J Clin Microbiol, vol.38, pp.1048-52, 2000.

J. M. Pagès, C. E. James, and M. Winterhalter, The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria, Nat Rev Microbiol, vol.6, pp.893-903, 2008.

J. P. Lavigne, A. Sotto, M. H. Nicolas-chanoine, N. Bouziges, and G. Bourg, Membrane permeability, a pivotal function involved in antibiotic resistance and virulence in Enterobacter aerogenes clinical isolates, Clin Microbiol Infect, vol.18, pp.539-584, 2012.

J. P. Lavigne, A. Sotto, M. H. Nicolas-chanoine, N. Bouziges, and J. M. Pagès, An adaptive response of Enterobacter aerogenes to imipenem: regulation of porin balance in clinical isolates, Int J Antimicrob Agents, vol.41, pp.130-136, 2013.

J. Chevalier, C. Mulfinger, E. Garnotel, P. Nicolas, and A. Davin-regli, Identification and evolution of drug efflux pump in clinical Enterobacter aerogenes strains isolated in 1995 and, PLoS ONE, vol.3, p.3203, 2003.

R. Chollet, J. Chevalier, C. Bollet, J. M. Pages, and A. Davin-regli, RamA is an alternate activator of the multidrug resistance cascade in Enterobacter aerogenes, Antimicrob Agents Chemother, vol.48, pp.2518-2541, 2004.

D. Keeney, A. Ruzin, and P. A. Bradford, RamA, a transcriptional regulator, and AcrAB, an RND-type efflux pump, are associated with decreased susceptibility to tigecycline in Enterobacter cloacae, Microb Drug Resist, vol.13, pp.1-6, 2007.

E. Nikaido, A. Yamaguchi, and K. Nishino, AcrAB multidrug efflux pump regulation in Salmonella enterica serovar Typhimurium by RamA in response to environmental signals, J Biol Chem, vol.283, pp.24245-53, 2008.

E. O'regan, T. Quinn, J. M. Pagès, M. Mccusker, and P. , Multiple regulatory pathways associated with high-level ciprofloxacin and multidrug resistance in Salmonella enterica serovar enteritidis: involvement of RamA and other global regulators, Antimicrob Agents Chemother, vol.53, pp.1080-1087, 2009.

A. M. Bailey, A. Ivens, R. Kingsley, J. L. Cottell, and W. J. ,

, AraC/XylS family, influences both virulence and efflux in Salomella enterica serovar Typhimurium, J Bacteriol, vol.192, pp.1607-1623, 2010.

A. J. Lawler, V. Ricci, S. J. Busby, and L. J. Piddock, Genetic inactivation of acrAB or inhibition of efflux induces expression of ramA, J Antimicrob Chemother, vol.68, pp.1551-1558, 2013.

R. Chollet, C. Bollet, J. Chevalier, M. Malléa, and J. M. Pagès, mar operon involved in multidrug resistance of Enterobacter aerogenes, Antimicrob. Agents Chemother, vol.46, pp.1093-1100, 2002.

S. Bratu, D. Landman, A. George, J. Salvani, and J. Quale, Correlation of the expression of acrB and the regulatory genes marA, soxS and ramA with antimicrobial resistance in clinical isolates of Klebsiella pneumoniae endemic to New York City, J Antimicrob Chemother, vol.64, pp.278-83, 2009.

R. G. Martin, E. S. Bartlett, J. L. Rosner, and M. E. Wall, Activation of the E. coli marA/soxS/rob regulon in response to transcriptional activator concentration, J Mol Biol, vol.380, pp.278-284, 2008.

D. Majumdar, S. Yu, J. Fookes, M. Mcateer, S. P. Llobet et al., Elucidation of the RamA regulon in Klebsiella pneumoniae reveals a role in LPS regulation, PLoS Pathog, vol.11, p.1004627, 2015.

R. Rosenblum, E. Khan, E. Gonzalez, E. R. Hasan, and T. Schneiders, Genetic regulation of the ramA locus and its expression in clinical isolates of Klebsiella pneumoniae, Int J Antimicrob Agents, vol.38, pp.39-45, 2011.

Y. Chen, D. Hu, Q. Zhang, X. P. Liao, and Y. H. Liu, Efflux Pump Overexpression Contributes to Tigecycline Heteroresistance in Salmonella enterica serovar Typhimurium, Front Cell Infect Microbiol, vol.7, p.37, 2017.

A. Fàbrega, C. Ballesté-delpierre, and J. Vila, Differential impact of ramRA mutations on both ramA transcription and decreased antimicrobial susceptibility in Salmonella Typhimurium

, J Antimicrob Chemother, vol.71, pp.617-641, 2016.

J. C. Jiménez-castellanos, W. A. Kamil, W. N. Cheung, C. H. Tobin, M. S. Brown et al., Comparative effects of overproducing the AraC-type transcriptional regulators MarA, SoxS, RarA and RamA on antimicrobial drug susceptibility in Klebsiella pneumoniae, J Antimicrob Chemother, vol.7, pp.1820-1825, 2016.

S. Yamasaki, E. Nikaido, R. Nakashima, K. Sakurai, and D. Fujiwara, The crystal structure of multidrug-resistance regulator RamR with multiple drugs, Nat Commun, vol.4, p.2078, 2013.

K. Maneewannakul and S. B. Levy, Identification of Mar mutants among clinical isolates of quinolone resistant Escherichia coli, Antimicrob Agents Chemother, vol.40, pp.1695-1698, 1996.

S. Yaron, D. G. White, and K. R. Matthews, Characterization of an Escherichia coli O157:H7 marR mutant, Int J Food Microbiol, vol.85, pp.281-291, 2003.

Y. M. Abouzeed, S. Baucheron, and A. Cloeckaert, ramR mutations involved in efflux-mediated multidrug resistance in Salmonella enterica serovar Typhimurium, Antimicrob Agents Chemother, vol.52, pp.2428-2434, 2008.

N. Philippe, L. Maigre, S. Santini, E. Pinet, and J. M. Claverie, In Vivo Evolution of Bacterial Resistance in Two Cases of Enterobacter aerogenes Infections during Treatment with Imipenem, PLoS One, 138828.
URL : https://hal.archives-ouvertes.fr/hal-01237665

S. Bialek-davenet, E. Marcon, V. Leflon-guibout, J. Lavigne, and B. F. , In vitro selection of ramR and soxR mutants overexpressing efflux systems by fluoroquinolones as well as cefoxitin in Klebsiella pneumoniae, J Antimicrob Chemother, vol.55, pp.2795-802, 2011.

C. Kehrenberg, A. Cloeckaert, G. Klein, and S. Schwarz, Decreased fluoroquinolone susceptibility in mutants of Salmonella serovars other than Typhimurium: detection of novel mutations involved in modulated expression of ramA and soxS, J Antimicrob Chemother, vol.64, pp.1175-80, 2009.

M. Hentschke, M. Wolters, I. Sobottka, H. Rohde, and M. Aepfelbacher, RamR mutations in clinical isolates of Klebsiella pneumoniae with reduced susceptibility to tigecycline, Antimicrob Agents Chemother, vol.54, pp.2720-2723, 2010.

S. Bialek-davenet, V. Leflon-guibout, T. Minh, O. Marcon, E. Moreau et al., Complete deletion of the ramR gene in an in vitro-selected mutant of Klebsiella pneumoniae overexpressing the AcrAB efflux pump, Antimicrob Agents Chemother, vol.57, pp.672-675, 2013.

A. Seoane and S. B. Levy, Characterization of MarR, the repressor of the multiple antibiotic resistance (mar) operon in Escherichia coli, J Bacteriol, vol.177, pp.3414-3419, 1995.

M. N. Alekshun and S. B. Levy, Mutational analysis of MarR, the negative regulator of marRAB expression in Escherichia coli, suggests the presence of two regions required for DNA binding, Mol Microbiol, vol.35, pp.1394-1404, 2000.

H. J. Linde, F. Notka, M. Metz, B. Kochanowski, and P. Heisig, In vivo increase in resistance to ciprofloxacin in Escherichia coli associated with deletion of the C-terminal part of MarR, Antimicrob Agents Chemother, vol.44, pp.1865-1873, 2000.

S. Baucheron, L. Hello, S. Doublet, B. , G. E. Weill et al., ramR mutations affecting fluoroquinolone susceptibility in epidemic multidrug-resistant Salmonella enterica serovar Kentucky ST198, Front Microbiol, vol.4, p.213, 2013.
URL : https://hal.archives-ouvertes.fr/pasteur-01109819

L. Villa, C. Feudi, D. Fortini, A. García-fernández, and A. Carattoli, Genomics of KPCproducing Klebsiella pneumoniae sequence type 512 clone highlights the role of RamR and ribosomal S10 protein mutations in conferring tigecycline resistance, Antimicrob Agents Chemother, vol.58, pp.1707-1719, 2014.

C. Belmar-campos, M. Aepfelbacher, and M. Hentschke, Molecular Analysis of the ramRA locus in clinical Klebsiella pneumoniae isolates with reduced susceptibility to tigecycline, New Microbiol, vol.40, pp.135-138, 2017.

K. J. Livak and T. D. Schmittgen, Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method, Methods, vol.25, pp.402-410, 2001.

M. Veleba, D. Majumdar, S. Hornsey, M. Woodford, N. Schneiders et al., Genetic characterization of tigecycline resistance in clinical isolates of Enterobacter cloacae and Enterobacter aerogenes, J Antimicrob Chemother, vol.68, pp.1011-1019, 2013.

X. Wang, H. Chen, Y. Zhang, Q. Wang, and C. Zhao, Genetic characterisation of clinical Klebsiella pneumoniae isolates with reduced susceptibility to tigecycline: Role of the global regulator RamA and its local repressor RamR, Int J Antimicrob Agents, vol.45, pp.635-675, 2015.

D. K. Deochand and A. Grove, MarR family transcription factors: dynamic variations on a common scaffold, Crit Rev Biochem Mol Biol, vol.3, pp.1-19, 2017.

D. Ghisalberti, M. Masi, J. M. Pagès, and J. Chevalier, Chloramphenicol and expression of multidrug efflux pump in Enterobacter aerogenes, Biochem Biophys Res Commun, vol.328, pp.1113-1121, 2005.