L. B. Rice, Progress and Challenges in Implementing the Research on ESKAPE Pathogens, Infection Control & Hospital Epidemiology, vol.10, issue.S1, pp.7-10, 2010.
DOI : 10.1111/j.1365-2958.1995.tb02268.x

H. W. Boucher, Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America, Clinical Infectious Diseases, vol.39, issue.1, pp.1-12, 2009.
DOI : 10.1086/591389

E. M. Wellington, The role of the natural environment in the emergence of antibiotic resistance in Gram-negative bacteria, The Lancet Infectious Diseases, vol.13, issue.2, pp.155-165, 2013.
DOI : 10.1016/S1473-3099(12)70317-1

S. Manzetti and R. Ghisi, The environmental release and fate of antibiotics, Marine Pollution Bulletin, vol.79, issue.1-2, pp.7-15, 2014.
DOI : 10.1016/j.marpolbul.2014.01.005

D. I. Andersson and D. Hughes, Persistence of antibiotic resistance in bacterial populations, FEMS Microbiology Reviews, vol.59, issue.(suppl 1), pp.901-911, 2011.
DOI : 10.1098/rsbl.2006.0478
URL : https://academic.oup.com/femsre/article-pdf/35/5/901/18129254/35-5-901.pdf

D. I. Andersson and D. Hughes, Microbiological effects of sublethal levels of antibiotics, Nature Reviews Microbiology, vol.172, issue.7, pp.465-78, 2014.
DOI : 10.1093/jac/17.4.409

A. Davin-regli, Membrane Permeability and Regulation of Drug “Influx and Efflux” in Enterobacterial Pathogens, Current Drug Targets, vol.9, issue.9, pp.750-759, 2008.
DOI : 10.2174/138945008785747824

J. Pagès, C. E. James, and M. Winterhalter, The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria, Nature Reviews Microbiology, vol.390, issue.12, pp.893-903, 2008.
DOI : 10.1016/S0969-2126(99)80055-0

H. Nikaido and J. M. Pagès, Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria, FEMS Microbiology Reviews, vol.36, issue.2, pp.340-363, 2012.
DOI : 10.1586/eri.09.108
URL : https://academic.oup.com/femsre/article-pdf/36/2/340/18129109/36-2-340.pdf

H. Nikaido, Multidrug Resistance in Bacteria, Annual Review of Biochemistry, vol.78, issue.1, pp.119-165, 2009.
DOI : 10.1146/annurev.biochem.78.082907.145923

J. H. Rex, M. Goldberger, B. I. Eisenstein, and C. Harney, The evolution of the regulatory framework for antibacterial agents, Annals of the New York Academy of Sciences, vol.12, issue.Suppl 3), p.12441
DOI : 10.1038/nrd3957-c1

J. H. Rex, A comprehensive regulatory framework to address the unmet need for new antibacterial treatments, The Lancet Infectious Diseases, vol.13, issue.3, pp.269-75, 2013.
DOI : 10.1016/S1473-3099(12)70293-1

R. Cantón and M. I. Morosini, Emergence and spread of antibiotic resistance following exposure to antibiotics, FEMS Microbiology Reviews, vol.68, issue.(suppl 2), pp.977-91, 2011.
DOI : 10.1128/AAC.47.3.1023-1027.2003

R. Laxminarayan, Antibiotic resistance???the need for global solutions, The Lancet Infectious Diseases, vol.13, issue.12, pp.1057-98, 2013.
DOI : 10.1016/S1473-3099(13)70318-9
URL : https://dukespace.lib.duke.edu/dspace/bitstream/10161/8996/1/CarsEtAl_AntibioticResistance-TheNeedforGlobalSolutions_LancetInfectiousDiseases_2013%5b1%5d.pdf

J. S. Chapman and N. H. Georgopapadakou, 17968 | DOI: 10.1038/srep17968 15 Fluorometric assay for fleroxacin uptake by bacterial cells, Antimicrob. Agents Chemother, vol.5, issue.33, pp.27-36, 1989.

S. Ka??áková, L. Maigre, J. Chevalier, M. Réfrégiers, and J. M. Pagès, Antibiotic Transport in Resistant Bacteria: Synchrotron UV Fluorescence Microscopy to Determine Antibiotic Accumulation with Single Cell Resolution, PLoS ONE, vol.14, issue.4, 2012.
DOI : 10.1371/journal.pone.0038624.s004

F. Jamme, Synchrotron UV Fluorescence Microscopy Uncovers New Probes in Cells and Tissues, Microscopy and Microanalysis, vol.91, issue.05, pp.507-521, 2010.
DOI : 10.1366/0003702953965597
URL : https://hal.archives-ouvertes.fr/hal-00609593

F. Jamme, Deep UV autofluorescence microscopy for cell biology and tissue histology, Biology of the Cell, vol.100, issue.10, pp.277-88, 2013.
DOI : 10.1073/pnas.0832308100

B. D. Bax, Type IIA topoisomerase inhibition by a new class of antibacterial agents, Nature, vol.60, issue.7309, pp.935-975, 2010.
DOI : 10.1017/S003358350800468X

E. Pradel and J. M. Pagès, The AcrAB-TolC Efflux Pump Contributes to Multidrug Resistance in the Nosocomial Pathogen Enterobacter aerogenes, Antimicrobial Agents and Chemotherapy, vol.46, issue.8, pp.2640-2643, 2002.
DOI : 10.1128/AAC.46.8.2640-2643.2002
URL : http://aac.asm.org/content/46/8/2640.full.pdf

M. Mallea, Porin alteration and active efflux: two in vivo drug resistance strategies used by Enterobacter aerogenes, Microbiology, vol.144, issue.11, pp.3003-3012, 1998.
DOI : 10.1099/00221287-144-11-3003
URL : http://mic.microbiologyresearch.org/deliver/fulltext/micro/144/11/mic-144-11-3003.pdf?itemId=/content/journal/micro/10.1099/00221287-144-11-3003&mimeType=pdf&isFastTrackArticle=

M. Malléa, J. Chevalier, A. Eyraud, and J. M. Pagès, Inhibitors of antibiotic efflux pump in resistant Enterobacter aerogenes strains, Biochemical and Biophysical Research Communications, vol.293, issue.5, pp.1370-1373, 2002.
DOI : 10.1016/S0006-291X(02)00404-7

K. Zuiderveld, Contrast Limited Adaptive Histogram Equalization, Graphics Gems IV (P. Heckbert, 1994.
DOI : 10.1016/B978-0-12-336156-1.50061-6

S. Sternberg, Biomedical Image Processing. Computer (Long. Beach. Calif), vol.16, pp.22-34, 1983.

J. N. Kapur, P. K. Sahoo, and A. K. Wong, A new method for gray-level picture thresholding using the entropy of the histogram, Computer Vision, Graphics, and Image Processing, vol.29, issue.1, p.140, 1985.
DOI : 10.1016/S0734-189X(85)90156-2

L. Bretzner, Feature Tracking with Automatic Selection of Spatial Scales, Computer Vision and Image Understanding, vol.71, issue.3, pp.385-92, 1998.
DOI : 10.1006/cviu.1998.0650

F. Chang, C. J. Chen, and C. J. Lu, A linear-time component-labeling algorithm using contour tracing technique, Computer Vision and Image Understanding, vol.93, issue.2, pp.206-226, 2004.
DOI : 10.1016/j.cviu.2003.09.002

L. Trón, Flow cytometric measurement of fluorescence resonance energy transfer on cell surfaces. Quantitative evaluation of the transfer efficiency on a cell-by-cell basis, Biophysical Journal, vol.45, issue.5, pp.939-985, 1984.
DOI : 10.1016/S0006-3495(84)84240-X

Y. He and D. Hader, UV-B-induced formation of reactive oxygen species and oxidative damage of the cyanobacterium Anabaena sp.: protective effects of ascorbic acid and N-acetyl-l-cysteine, Journal of Photochemistry and Photobiology B: Biology, vol.66, issue.2, pp.115-139, 2002.
DOI : 10.1016/S1011-1344(02)00231-2

D. E. Heck, A. M. Vetrano, T. M. Mariano, and J. D. Laskin, UVB Light Stimulates Production of Reactive Oxygen Species, Journal of Biological Chemistry, vol.59, issue.25, pp.22432-22438, 2003.
DOI : 10.2307/3577149

A. R. Deschreider and M. Renard, The Influence of Ultraviolet Rays on the Absorption Spectrum of L-Tryptophan, Bull. Inst. Agron. Stas. Rech, vol.23, pp.151-65, 1955.

Y. Fukunaga and F. Sakiyama, Fluorescence Titrations of Residue 59 and Tyrosine in Kyn 59-RNase T1 and NFK 59-RNase T11, The Journal of Biochemistry, vol.92, issue.1, pp.155-61, 1982.
DOI : 10.1093/oxfordjournals.jbchem.a133912

T. Simat and H. Steinhart, Oxidation of Free Tryptophan and Tryptophan Residues in Peptides and Proteins, Journal of Agricultural and Food Chemistry, vol.46, issue.2, pp.490-498, 1998.
DOI : 10.1021/jf970818c

M. Winterhalter, Physical methods to quantify small antibiotic molecules uptake into Gram-negative bacteria in Eur, J. Pharm. Biopharm, p.15, 2015.

T. Gutsmann, Protein reconstitution into freestanding planar lipid membranes for electrophysiological characterization, Nature Protocols, vol.165, issue.1, pp.188-98, 2015.
DOI : 10.1007/s002490050138

O. Kocaoglu and E. Carlson, ABSTRACT, Antimicrobial Agents and Chemotherapy, vol.59, issue.5, pp.2785-90, 2015.
DOI : 10.1128/AAC.04552-14

C. M. June, A fluorescent carbapenem for structure function studies of penicillin-binding proteins, ??-lactamases, and ??-lactam sensors, Analytical Biochemistry, vol.463, pp.70-74, 2014.
DOI : 10.1016/j.ab.2014.07.012

A. Giuliani, DISCO: a low-energy multipurpose beamline at synchrotron SOLEIL, Journal of Synchrotron Radiation, vol.16, issue.6, pp.835-876, 2009.
DOI : 10.1107/S0909049509034049
URL : https://hal.archives-ouvertes.fr/hal-01479318

A. Edelstein, N. Amodaj, K. Hoover, R. Vale, and N. Stuurman, Computer Control of Microscopes Using ??Manager, Curr. Protoc. Mol. Biol, vol.15, issue.20, pp.1-20, 2012.
DOI : 10.1002/0471142727.mb1420s92