Targeting adrenomedullin receptors with systemic delivery of neutralizing antibodies inhibits tumor angiogenesis and suppresses growth of human tumor xenografts in mice

Itidal Kaafarani (1) , Samantha Fernandez-Sauze (1) , Caroline Berenguer (1) , Olivier Chinot (2, 1, 3) , Christine Delfino (1) , Christophe Dussert (1) , Philippe Metellus (4, 1) , François Boudouresque (1) , Kamel Mabrouk (5) , François Grisoli (6) , Dominique Figarella-Branger (7, 1) , Pierre-Marie Martin (3, 1) , L'Houcine Ouafik (1, 3)

1 CRO2 - Centre de Recherches en Oncologie biologique et Oncopharmacologie
2 Département de neurooncologie
3 Laboratoire de Transfert d'Oncologie Biologique [Hôpital Nord - APHM]
4 Département de Neurochirurgie [CHU Timone]
5 IP - Ingénierie des protéines
6 Service de neurochirurgie
7 Service d’Anatomopathologie

Domains: Life Sciences [q-bio]; Cancer

Itidal Kaafarani, Samantha Fernandez-Sauze, Caroline Berenguer, Olivier Chinot, Christine Delfino, et al.. Targeting adrenomedullin receptors with systemic delivery of neutralizing antibodies inhibits tumor angiogenesis and suppresses growth of human tumor xenografts in mice. FASEB Journal, 2009, 23 (10), pp.3424 - 3435. ⟨10.1096/fj.08-127852⟩. ⟨hal-01848088⟩