Skip to Main content Skip to Navigation
New interface
Journal articles

Dynamic Changes in Interneuron Morphophysiological Properties Mark the Maturation of Hippocampal Network Activity

Abstract : During early postnatal development, neuronal networks successively produce various forms of spontaneous patterned activity that provide key signals for circuit maturation. Initially, in both rodent hippocampus and neocortex, coordinated activity emerges in the form of synchronous plateau assemblies (SPAs) that are initiated by sparse groups of gap-junction-coupled oscillating neurons. Subsequently, SPAs are replaced by synapse-driven giant depolarizing potentials (GDPs). Whether these sequential changes in mechanistically distinct network activities correlate with modifications in single-cell properties is unknown. To determine this, we studied the morphophysio-logical fate of single SPA cells as a function of development. We focused on CA3 GABAergic interneurons, which are centrally involved in generating GDPs in the hippocampus. As the network matures, GABAergic neurons are engaged more in GDPs and less in SPAs. Using inducible genetic fate mapping, we show that the individual involvement of GABAergic neurons in SPAs is correlated to their temporal origin. In addition, we demonstrate that the SPA-to-GDP transition is paralleled by a remarkable maturation in the morphophysiological properties of GABAergic neurons. Compared with those involved in GDPs, interneurons participating in SPAs possess immature intrinsic properties, receive synaptic inputs spanning a wide amplitude range, and display large somata as well as membrane protrusions. Thus, a developmental switch in the morphophysiological properties of GABAergic interneurons as they progress from SPAs to GDPs marks the emergence of synapse-driven network oscillations.
Complete list of metadata

Cited literature [37 references]  Display  Hide  Download
Contributor : Rosa Cossart Connect in order to contact the contributor
Submitted on : Tuesday, July 24, 2018 - 1:59:14 PM
Last modification on : Tuesday, October 19, 2021 - 10:51:08 PM
Long-term archiving on: : Thursday, October 25, 2018 - 3:17:10 PM


Publisher files allowed on an open archive




Camille Allène, Michel A. Picardo, Hélène Becq, Goichi Miyoshi, Gord Fishell, et al.. Dynamic Changes in Interneuron Morphophysiological Properties Mark the Maturation of Hippocampal Network Activity. Journal of Neuroscience, 2012, 32 (19), pp.6688-6698. ⟨10.1523/JNEUROSCI.0081-12.2012⟩. ⟨hal-01848199⟩



Record views


Files downloads