The maturation of cortical interneuron diversity: how multiple developmental journeys shape the emergence of proper network function

Rosa Cossart (1)

1 INMED - INSERM U1249 - Institut de Neurobiologie de la Méditerranée [Aix-Marseille Université]

If the classical functional attribute of cortical GABAergic interneurons is to mediate synaptic inhibition in the adult cortex, it is becoming evident that their major task is instead to shape the spatio-temporal dynamics of the network oscillations that support most brain functions. This complex function involves a division of labour between morpho-physiologically diverse interneuron subtypes. Both the central network function and the bewildering heterogeneity of the interneuron population are especially emphasized during cortical development: at early postnatal stages, a single GABAergic neuron can efficiently pace the activity of hundreds of other cells, whereas some interneuron subtypes are still poorly developed. Given the role of coherent activity in brain development, this confers to GABAergic interneurons a major role in the proper maturation of cortical networks.

Domaines: Neurobiologie

Rosa Cossart. The maturation of cortical interneuron diversity: how multiple developmental journeys shape the emergence of proper network function. Current Opinion in Neurobiology, 2011, 21 (1), pp.160-168. ⟨10.1016/j.conb.2010.10.003⟩. ⟨hal-01848218⟩