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Human germinal center transcriptional programs are de-synchronized in B cell lymphoma

Abstract : Most adult B cell lymphomas originate from germinal center (GC) B cells, but it is unclear to what extent B cells in overt lymphoma retain the functional dynamics of GC B cells or are blocked at a particular stage of the GC reaction. Here we used integrative single-cell analysis of phenotype, gene expression and variable-region sequence of the immunoglobulin heavy-chain locus to track the characteristic human GC B cell program in follicular lymphoma B cells. By modeling the cyclic continuum of GC B cell transitional states, we identified characteristic patterns of synchronously expressed gene clusters. GC-specific gene-expression synchrony was lost in single lymphoma B cells. However, distinct follicular lymphoma-specific cell states co-existed within single patient biopsies. Our data show that lymphoma B cells are not blocked in a GC B cell state but might adopt new dynamic modes of functional diversity, which opens the possibility of novel definitions of lymphoma identity.
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https://hal-amu.archives-ouvertes.fr/hal-01858136
Contributor : Lionel Spinelli Connect in order to contact the contributor
Submitted on : Monday, August 20, 2018 - 8:51:05 AM
Last modification on : Tuesday, February 1, 2022 - 3:40:02 PM

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Pierre Milpied, Iñaki Cervera-Marzal, Marie-Laure Mollichella, Bruno Tesson, Gabriel Brisou, et al.. Human germinal center transcriptional programs are de-synchronized in B cell lymphoma. Nature Immunology, Nature Publishing Group, 2018, 19 (9), pp.1013 - 1024. ⟨10.1038/s41590-018-0181-4⟩. ⟨hal-01858136⟩

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