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Characterization of adrenocortical tumors by F-18-FDG PET/CT: Does steroid hormone hypersecretion status modify the uptake pattern?

Abstract : Background: adrenal tumor-to-liver uptake value (Tmx:Lmx) on F-18-FDG PET/CT is an accurate and reproducible PET parameter in the distinction between benign and malignant adrenal masses. The potential impact of steroid hormone secretion on F-18-FDG uptake is still debatable. The aim of this study was to evaluate this relationship. Methods: 2010-2015: 73 patients who underwent adrenalectomy for adrenocortical tumors [49 secreting/(SA) and 24 non-secreting/(NSA)] were retrospectively included in the study. Fourteen were malignant. All patients underwent hormonal evaluation, functional and anatomical imaging, Weiss scoring and Ki 67 evaluation. Results: malignant tumors exhibit higher SUV-max than benign tumors (median 7.75 vs 3.06 respectively, p <0.001) and Tmx:Lmx was 2.7 vs 1.17 for benign tumors, p <0.001. Tmx:Lmx was positively correlated to Weiss score (p <0.001). No significant difference was observed for Tmx:Lmx between SA and NSA overall (p = 0.851), regardless of the subgroup of tumors analyzed. Tmx:Lmx was not correlated to tumor size (p <0.508) or 24 h free urinary cortisol level (p <0.522). Conclusions: no correlation was observed between Tmx:Lmx and hormonal status, however the correlation between ratio, malignancy and Weiss score confirm the utility of F-18-FDG PET/CT for the differentiation of benign from malignant adrenal lesions, irrespective of the hormone secretory status of the tumor. F-18-FDG PET/CT is a useful biomarker in the diagnosis of adrenal tumors, regardless of the secretion status. (C) 2018 Elsevier Ltd. All rights reserved.
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https://hal-amu.archives-ouvertes.fr/hal-01876276
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Submitted on : Tuesday, September 18, 2018 - 12:21:17 PM
Last modification on : Wednesday, November 3, 2021 - 6:45:21 AM

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Nunzia Cinzia Paladino, Carole Guerin, Aoife Lowery, Andrea Attard, Wassim Essamet, et al.. Characterization of adrenocortical tumors by F-18-FDG PET/CT: Does steroid hormone hypersecretion status modify the uptake pattern?. Surgical Oncology, Elsevier, 2018, 27 (2), pp.231-235. ⟨10.1016/j.suronc.2018.04.003⟩. ⟨hal-01876276⟩

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