A Mycobacterium marinum TesA mutant defective for major cell wall-associated lipids is highly attenuated in Dictyostelium discoideum and zebrafish embryos, Mol Microbiol, vol.80, pp.919-953, 2011. ,
URL : https://hal.archives-ouvertes.fr/hal-00641589
Phthiocerol dimycocerosates of M. tuberculosis participate in macrophage invasion by inducing changes in the organization of plasma membrane lipids, PLoS Pathog, vol.5, p.1000289, 2009. ,
URL : https://hal.archives-ouvertes.fr/hal-02333313
Role of PGL-I of M. leprae in TNF-alpha production by in vitro whole blood assay, Nepal Med Coll J, vol.10, pp.1-3, 2008. ,
Mycobacterial phenolic glycolipid virulence factor biosynthesis: mechanism and smallmolecule inhibition of polyketide chain initiation, Chem Biol, vol.15, pp.51-61, 2008. ,
Synthesis and kinetic evaluation of cyclophostin and cyclipostins phosphonate analogs as selective and potent inhibitors of microbial lipases, J Med Chem, vol.55, pp.10204-10223, 2012. ,
,
, J Med Chem, vol.56, pp.4393-401, 2013.
Synthesis and comparison of the biological activity of monocyclic phosphonate, difluorophosphonate and phosphate analogs of the natural AChE inhibitor cyclophostin, Bioorg Med Chem, vol.23, pp.7529-7563, 2015. ,
Rat hormone sensitive lipase inhibition by cyclipostins and their analogs, Bioorg Med Chem, vol.23, pp.944-52, 2015. ,
Cyclophostin and cyclipostins analogs, new promising molecules to treat mycobacterialrelated diseases, Int J Antimicrob Agents, vol.51, pp.651-655, 2018. ,
Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis, Sci Rep, vol.7, p.11751, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01791688
Inactivation of tesA reduces cell wall lipid production and increases drug susceptibility in mycobacteria, J Biol Chem, vol.286, pp.24616-24641, 2011. ,
A proteomic view of mycobacteria, Proteomics, vol.11, pp.3118-3145, 2011. ,
Comprehensive proteomic profiling of the membrane constituents of a Mycobacterium tuberculosis strain, Mol Cell Proteomics, vol.2, pp.1284-96, 2003. ,
High-resolution cholesterol catabolism, PLoS Pathog, vol.7, p.1002251, 2011. ,
Inactivation of polyketide synthase and related genes results in the loss of complex lipids in Mycobacterium tuberculosis H37Rv, Lett Appl Microbiol, vol.40, pp.201-207, 2005. ,
Interaction studies on proteins encoded by the phthiocerol dimycocerosate locus of Mycobacterium tuberculosis, Mol Genet Genomics, vol.272, pp.571-580, 2004. ,
Structural and functional characterisation of TesA -a novel lysophospholipase A from Pseudomonas aeruginosa, PLoS One, vol.8, p.69125, 2013. ,
Tetrahydrolipstatin inhibition, functional analyses, and three-dimensional structure of a lipase essential for mycobacterial viability, J Biol Chem, vol.285, pp.30050-60, 2010. ,
Mycobacterium tuberculosis Rv3802c encodes a phospholipase/thioesterase and is inhibited by the antimycobacterial agent tetrahydrolipstatin, PLoS One, vol.4, p.4281, 2009. ,
, Effects of Surfactants on Lipase Structure, Activity and Inhibition. Pharmaceutical Research, vol.28, pp.1831-1873, 2011.
Distinction between esterases and lipases: a kinetic study with vinyl esters and TAG, Lipids, vol.37, pp.653-62, 2002. ,
New lipase assay using Pomegranate oil coating in microtiter plates, Biochimie, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01472891
Two cutinase-like proteins secreted by Mycobacterium tuberculosis show very different lipolytic activities reflecting their physiological function, Faseb J, vol.24, pp.1893-903, 2010. ,
Targeting Lipid Esterases in Mycobacteria Grown Under Different Physiological Conditions Using Activitybased Profiling with Tetrahydrolipstatin (THL), Mol Cell Proteomics, vol.13, pp.435-483, 2014. ,
Activity-based protein profiling: The serine hydrolases, Proc Natl Acad Sci, vol.96, pp.14694-14703, 1999. ,
Exploring the specific features of interfacial enzymology based on lipase studies, Biochimica et Biophysica Acta (BBA) -Molecular and Cell Biology of Lipids, vol.1761, pp.995-1013, 2006. ,
Rapid identification of proteins by peptidemass fingerprinting, Curr Biol, vol.3, pp.327-359, 1993. ,
Cyclipostins and Cyclophostin analogs inhibit the antigen 85C from Mycobacterium tuberculosis both in vitro and in vivo, J Biol Chem, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01770061
Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis, Science, vol.276, pp.1420-1422, 1997. ,
Inactivation of the antigen 85C gene profoundly affects the mycolate content and alters the permeability of the Mycobacterium tuberculosis cell envelope, Mol Microbiol, vol.31, pp.1573-87, 1999. ,
Structure and functional analysis of RifR, the type II thioesterase from the rifamycin biosynthetic pathway, J Biol Chem, vol.284, pp.5021-5030, 2009. ,
Inference of Macromolecular Assemblies from Crystalline State, Journal of Molecular Biology, vol.372, pp.774-97, 2007. ,
Alpha/beta hydrolase fold: an update, Protein Pept Lett, vol.16, pp.1137-1185, 2009. ,
, Biochemistry, vol.33, pp.83-92, 1994.
The Lid Domain in Lipases: Structural and Functional Determinant of Enzymatic Properties, Front Bioeng Biotechnol, vol.5, p.16, 2017. ,
Interfacial activation of the lipaseprocolipase complex by mixed micelles revealed by X-Ray crystallography, Nature, vol.362, pp.814-834, 1993. ,
Dali server: conservation mapping in 3D, Nucleic Acids Res, vol.38, pp.545-554, 2010. ,
Crystal structure of human gastric lipase and model of lysosomal acid lipase, two lipolytic enzymes of medical interest, J Biol Chem, vol.274, pp.16995-7002, 1999. ,
Crystal structure of the open form of dog gastric lipase in complex with a phosphonate inhibitor, J Biol Chem, vol.277, pp.2266-74, 2002. ,
Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13, Cell, vol.170, pp.249-59, 2017. ,
Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans, Nature Genetics, vol.45, p.1176, 2013. ,
Mycobacterium tuberculosis Molecular Determinants of Infection, Survival Strategies, and Vulnerable Targets. Pathogens, vol.7, p.17, 2018. ,
The expanding diversity of Mycobacterium tuberculosis drug targets, ACS Infect Dis, 2018. ,
Hit Generation in TB Drug Discovery: From Genome to Granuloma, Chem Rev, 2018. ,
Advances in the development of new tuberculosis drugs and treatment regimens, Nat Rev Drug Discov, vol.12, pp.388-404, 2013. ,
Inhibition of dog and human gastric lipases by enantiomeric phosphonate inhibitors: a structure-activity study, Biochemistry, vol.42, pp.11587-93, 2003. ,
A topological model of the baseplate of lactococcal phage Tuc2009, J Biol Chem, vol.283, pp.2716-2739, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-02066265
MmPPOX Inhibits Mycobacterium tuberculosis Lipolytic Enzymes Belonging to the Hormone-Sensitive Lipase Family and Alters Mycobacterial Growth, PLoS One, vol.7, p.46493, 2012. ,
Interfacial enzyme kinetics of lipolysis, Annual Review Biophys Bioeng, vol.5, pp.77-117, 1976. ,
Competitive inhibition of lipolytic enzymes. I. A kinetic model applicable to water-insoluble competitive inhibitors, Biochimica et Biophysica Acta (BBA) -Molecular and Cell Biology of Lipids, vol.1043, pp.57-66, 1990. ,
Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels, Anal Chem, vol.68, pp.850-858, 1996. ,
Development of a technology for automation and miniaturization of protein crystallization, J Biotechnol, vol.85, pp.7-14, 2001. ,
, Acta Crystallogr D Biol Crystallogr, vol.66, pp.125-157, 2010.
PHENIX: a comprehensive Python-based system for macromolecular structure solution, Acta Crystallogr D Biol Crystallogr, vol.66, pp.213-234, 2010. ,
Coot: modelbuilding tools for molecular graphics, Acta Crystallogr D Biol Crystallogr, vol.60, pp.2126-2158, 2004. ,
Refinement of severely incomplete structures with maximum likelihood in BUSTER-TNT, Acta Crystallogr D Biol Crystallogr, vol.60, pp.2210-2231, 2004. ,
JLigand: a graphical tool for the CCP4 template-restraint library, Resolution limits (Å), vol.68, pp.75-77, 2012. ,
,
, Average B-factor per chain