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Strategies To Access γ-Hydroxy-γ-butyrolactams

Abstract : α,β-Unsaturated γ-hydroxy-γ-butyrolactams are of a great interest due to their presence in designed pharmaceutical molecules and numerous natural products displaying a broad spectrum of biological activities. In addition, these five-membered heterocyclic compounds are also relevant and versatile building blocks in organic synthesis. In this context, strategies for the construction of these scaffolds has triggered considerable attention and this review highlights the progress in the formation of α,β-unsaturated γ-hydroxy-γ-butyrolactams (5-hy-droxy-1,5-dihydro-2H-pyrrol-2-ones).
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Submitted on : Monday, October 29, 2018 - 2:00:11 PM
Last modification on : Tuesday, January 4, 2022 - 5:05:56 AM
Long-term archiving on: : Wednesday, January 30, 2019 - 3:26:31 PM

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Muhammad Idham Darussalam Mardjan, Jean-Luc Parrain, Laurent Commeiras. Strategies To Access γ-Hydroxy-γ-butyrolactams. SYNTHESIS, Georg Thieme Verlag, 2018, 50 (06), pp.1175 - 1198. ⟨10.1055/s-0036-1591886⟩. ⟨hal-01907703⟩

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