The sst1 resistance locus regulates evasion of type I interferon signaling by Chlamydia pneumoniae as a disease tolerance mechanism, PLoS Pathog, vol.9, 2013. ,
Structural conservation of interferon gamma among vertebrates, Cytokine Growth Factor Rev, vol.20, pp.115-139, 2009. ,
Tissue damage control in disease tolerance, Trends Immunol, vol.35, pp.483-94, 2014. ,
Evolutionary dynamics of pathogen resistance and tolerance, Evolution, vol.54, pp.51-63, 2000. ,
Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques, J Virol, vol.84, pp.7886-91, 2010. ,
URL : https://hal.archives-ouvertes.fr/pasteur-01968882
Mechanisms underlying ?? T-cell subset perturbations in SIV-infected Asian rhesus macaques, Blood, vol.116, pp.4148-57, 2010. ,
The multiple and complex and changeable scenarios of the Trypanosoma cruzi transmission cycle in the sylvatic environment, Acta Trop, vol.151, pp.1-15, 2015. ,
Impaired innate immunity in Tlr4(-/-) mice but preserved CD8+ T cell responses against Trypanosoma cruzi in Tlr4-, Tlr2-, Tlr9-or Myd88-deficient mice, PLoS Pathog, vol.6, 2010. ,
Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruzi, J Immunol, vol.187, pp.1903-1914, 2011. ,
Cutting edge, TLR9 and TLR2 signaling together account for MyD88dependent control of parasitemia in Trypanosoma cruzi infection, J Immunol, vol.177, pp.3515-3524, 2006. ,
Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88, J Immunol, vol.172, pp.1711-1719, 2004. ,
TLR-dependent induction of IFN-beta mediates host defense against Trypanosoma cruzi, J Immunol, vol.177, pp.7059-66, 2006. ,
NLRP3 controls Trypanosoma cruzi infection through a caspase-1dependent IL-1R-independent NO production, PLoS Negl Trop Dis, vol.7, 2013. ,
Interleukin-6 is required for parasite specific response and host resistance to Trypanosoma cruzi, Int J Parasitol, vol.32, 2002. ,
Pivotal role of interleukin-12 and interferon-gamma axis in controlling tissue parasitism and inflammation in the heart and central nervous system during Trypanosoma cruzi infection, Am J Pathol, vol.159, issue.10, pp.63019-63021, 2001. ,
IL-12-independent IFN-gamma production by T cells in experimental Chagas' disease is mediated by IL-18, J Immunol, vol.167, pp.3346-53, 2001. ,
IL-12p40 deficiency leads to uncontrolled Trypanosoma cruzi dissemination in the spinal cord resulting in neuronal death and motor dysfunction, PLoS ONE, vol.7, p.49022, 2012. ,
IL-17A promotes macrophage effector mechanisms against Trypanosoma cruzi by trapping parasites in the endolysosomal compartment, Immunobiology, vol.218, pp.910-933, 2013. ,
IL17 is necessary for host protection against acute-phase Trypanosoma cruzi infection, J Immunol, vol.185, pp.1150-1157, 2010. ,
Gamma interferon modulates CD95 (Fas) and CD95 ligand (Fas-L) expression and nitric oxide-induced apoptosis during the acute phase of Trypanosoma cruzi infection: a possible role in immune response control, Infect Immun, vol.67, pp.3864-71, 1999. ,
Inducible nitric oxide synthase is not essential for control of Trypanosoma cruzi infection in mice, Infect Immun, vol.72, pp.4081-4090, 2004. ,
Interferon-gamma-induced nitric oxide causes intrinsic intestinal denervation in Trypanosoma cruzi-infected mice, Am J Pathol, vol.164, issue.10, pp.63222-63223, 2004. ,
Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth, J Immunol, vol.175, pp.8165-72, 2005. ,
Signal transducer and activator of transcription 1 (STAT-1) plays a critical role in control of Trypanosoma cruzi infection, Immunology, vol.145, pp.225-256, 2015. ,
Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi, J Immunol, vol.165, pp.1520-1525, 2000. ,
Thymus atrophy during Trypanosoma cruzi infection is caused by an immuno-endocrine imbalance, Brain Behav Immun, vol.21, pp.890-900, 2007. ,
Role of NO synthase in the development of Trypanosoma cruziinduced cardiomyopathy in mice, Am J Trop Med Hyg, vol.80, pp.782-789, 2009. ,
Apoptosis-associated speck-like protein containing a caspase recruitment domain inflammasomes mediate IL-1? response and host resistance to Trypanosoma cruzi infection, J Immunol, vol.191, pp.3373-83, 2013. ,
P47phox ?/? mice are compromised in expansion and activation of CD8+ T cells and susceptible to Trypanosoma cruzi infection, PLoS Pathog, vol.10, p.1004516, 2014. ,
CCL2/MCP-1 controls parasite burden, cell infiltration, and mononuclear activation during acute Trypanosoma cruzi infection, J Leukoc Biol, vol.86, pp.1239-1285, 2009. ,
DOI : 10.1189/jlb.0309187
URL : https://jlb.onlinelibrary.wiley.com/doi/pdf/10.1189/jlb.0309187
CCR5 plays a critical role in the development of myocarditis and host protection in mice infected with Trypanosoma cruzi, J Infect Dis, vol.191, pp.627-663, 2005. ,
The CC chemokine receptor 5 is important in control of parasite replication and acute cardiac inflammation following infection with Trypanosoma cruzi, Infect Immun, vol.74, pp.135-178, 2006. ,
Intercellular adhesion molecule 1 deficiency leads to impaired recruitment of T lymphocytes and enhanced host susceptibility to infection with Trypanosoma cruzi, J Immunol, vol.173, pp.463-70, 2004. ,
CD28 is required for T cell activation and IFN-gamma production by CD4+ and CD8+ T cells in response to Trypanosoma cruzi infection, Microbes Infect, vol.6, pp.1133-1177, 2004. ,
Experimental Trypanosoma cruzi infection in platelet-activating factor receptor-deficient mice, Microbes Infect, vol.5, pp.789-96, 2003. ,
DOI : 10.1016/s1286-4579(03)00146-1
Galectin-1 prevents infection and damage induced by Trypanosoma cruzi on cardiac cells, PLoS Negl Trop Dis, vol.9, p.4148, 2015. ,
DOI : 10.1371/journal.pntd.0004148
URL : https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0004148&type=printable
The absence of myocardial calcium-independent phospholipase A2gamma results in impaired prostaglandin E2 production and decreased survival in mice with acute Trypanosoma cruzi infection, Infect Immun, vol.81, pp.2278-87, 2013. ,
Canonical PI3K? signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis, Nat Commun, vol.9, p.1513, 2018. ,
DOI : 10.1038/s41467-018-03986-3
URL : https://www.nature.com/articles/s41467-018-03986-3.pdf
Ebi3 prevents Trypanosoma cruzi-induced myocarditis by dampening IFN-?-driven inflammation. Front Immunol, vol.8, p.1213, 2017. ,
DOI : 10.3389/fimmu.2017.01213
URL : https://www.frontiersin.org/articles/10.3389/fimmu.2017.01213/pdf
Tumor necrosis factor alpha-mediated toxic shock in Trypanosoma cruziinfected interleukin 10-deficient mice, Infect Immun, vol.68, pp.4075-83, 2000. ,
IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi, J Immunol, vol.158, pp.3311-3317, 1997. ,
IL-17RA signaling reduces inflammation and mortality during Trypanosoma cruzi infection by recruiting suppressive IL-10-producing neutrophils, PLoS Pathog, vol.8, 2012. ,
Interferon-?, and other inflammatory mediators in cardiomyocyte signaling during Chagas disease cardiomyopathy, World J Cardiol, vol.6, pp.782-90, 2014. ,
DOI : 10.4330/wjc.v6.i8.782
URL : https://hal.archives-ouvertes.fr/hal-01592695
Trypanosoma cruzi evades the protective role of interferon-gamma-signaling in parasite-infected cells, PLoS ONE, vol.9, p.110512, 2014. ,
Tumor necrosis factor alpha mediates resistance to Trypanosoma cruzi infection in mice by inducing nitric oxide production in infected gamma interferon-activated macrophages, Infect Immun, vol.63, pp.4862-4869, 1995. ,
IFN-gamma-induced TNF-alpha expression is regulated by interferon regulatory factors 1 and 8 in mouse macrophages, J Immunol, vol.181, pp.4461-70, 2008. ,
Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in gamma interferon receptor or inducible nitric oxide synthase, vol.66, pp.1208-1223, 1998. ,
Up-regulation and sustained activation of Stat1 are essential for interferon-gamma (IFNgamma)-induced dual oxidase 2 (Duox2) and dual oxidase A2 (DuoxA2) expression in human pancreatic cancer cell lines, J Biol Chem, vol.286, pp.12245-56, 2011. ,
Interferon-gamma induced cell death: regulation and contributions of nitric oxide, cJun N-terminal kinase, reactive oxygen species and peroxynitrite, Biochim Biophys Acta, vol.1843, pp.2645-61, 2014. ,
DOI : 10.1016/j.bbamcr.2014.06.014
URL : https://doi.org/10.1016/j.bbamcr.2014.06.014
Intraphagosomal peroxynitrite as a macrophage-derived cytotoxin against internalized Trypanosoma cruzi: consequences for oxidative killing and role of microbial peroxiredoxins in infectivity, J Biol Chem, vol.286, pp.6627-6667, 2011. ,
Macrophages promote oxidative metabolism to drive nitric oxide generation in response to Trypanosoma cruzi, Infect Immun, vol.84, pp.3527-3568, 2016. ,
DOI : 10.1128/iai.00809-16
URL : https://iai.asm.org/content/iai/84/12/3527.full.pdf
Interferon-gamma: an overview of signals, mechanisms and functions, J Leukoc Biol, vol.75, pp.163-89, 2004. ,
DOI : 10.1189/jlb.0603252
URL : https://jlb.onlinelibrary.wiley.com/doi/pdf/10.1189/jlb.0603252
IFN-gamma, but not nitric oxide or specific IgG, is essential for the in vivo ,
, Trypanosoma cruzi parasites, Scand J Immunol, vol.66, pp.297-308, 2007.
1 and ICSBP control constitutive and IFN-gamma-regulated Tlr9 gene expression in mouse macrophages, J Leukoc Biol, vol.81, pp.1577-90, 2007. ,
DOI : 10.1189/jlb.0107036
URL : https://jlb.onlinelibrary.wiley.com/doi/pdf/10.1189/jlb.0107036
Elevated concentrations of CCL2 and tumor necrosis factor-alpha in chagasic cardiomyopathy, Clin Infect Dis, vol.38, pp.943-50, 2004. ,
Interferon-gamma promotes infection of astrocytes by Trypanosoma cruzi, PLoS ONE, vol.10, p.118600, 2015. ,
Cardiac gene expression profiling provides evidence for cytokinopathy as a molecular mechanism in Chagas' disease cardiomyopathy, Am J Pathol, vol.167, issue.10, pp.62976-62984, 2005. ,
Trypanosoma cruzi-infected cardiomyocytes produce chemokines and cytokines that trigger potent nitric oxide-dependent trypanocidal activity, Circulation, vol.102, pp.3003-3011, 2000. ,
DOI : 10.1161/01.cir.102.24.3003
URL : https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.102.24.3003
Nitric oxide is involved in control of Trypanosoma cruzi-induced parasitemia and directly kills the parasite in vitro, Infect Immun, vol.62, pp.5177-82, 1994. ,
Th17 cells are more protective than Th1 cells against the intracellular parasite Trypanosoma cruzi, PLoS Pathog, vol.12, p.1005902, 2016. ,
IL-17 family: cytokines, receptors and signaling, Cytokine, vol.64, pp.477-85, 2013. ,
WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production, Immunity, vol.19, pp.657-67, 2003. ,
Trypanosoma cruzi infection imparts a regulatory program in dendritic cells and T cells via galectin-1-dependent mechanisms, J Immunol, vol.195, pp.3311-3335, 2015. ,
Trypanosoma cruzi, IL-10, TNF, IFNgamma, and IL-12 regulate innate and acquired immunity to infection, Exp Parasitol, vol.84, pp.231-275, 1996. ,
IL-10: the master regulator of immunity to infection, J Immunol, vol.180, pp.5771-5778, 2008. ,
IL-17 produced during Trypanosoma cruzi infection plays a central role in regulating parasite-induced myocarditis, PLoS Negl Trop Dis, vol.4, p.604, 2010. ,
A novel immunoregulatory function for IL-23: inhibition of IL-12-dependent IFN-? production, Eur J Immunol, vol.40, pp.2236-2283, 2010. ,
Interleukin23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17, J Biol Chem, vol.278, pp.1910-1914, 2003. ,
The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing, Nat Rev Immunol, vol.14, pp.585-600, 2014. ,
Epstein-Barr virus-induced gene 3 suppresses T helper type 1, type 17 and type 2 immune responses after Trypanosoma cruzi infection and inhibits parasite replication by interfering with alternative macrophage activation, Immunology, vol.147, pp.338-386, 2016. ,
The two faces of IL-6 on Th1/Th2 differentiation, Mol Immunol, vol.39, pp.531-537, 2002. ,
Host cell invasion by Trypanosoma cruzi: a unique strategy that promotes persistence, FEMS Microbiol Rev, vol.36, pp.734-781, 2012. ,
Evasion of the immune response by Trypanosoma cruzi during acute infection, Front Immunol, vol.6, p.659, 2015. ,
The immune response to Trypanosoma cruzi: role of Toll-like receptors and perspectives for vaccine development, J Parasitol Res, p.507874, 2012. ,
Th-17 cytokines are associated with severity of Trypanosoma cruzi chronic infection in pediatric patients from endemic areas of Mexico, Acta Trop, vol.178, pp.134-175, 2018. ,
Clinical course of Chagas' heart disease: a comparison with dilated cardiomyopathy, Int J Cardiol, vol.60, pp.187-93, 1997. ,
The role of interleukin 17-mediated immune response in Chagas disease: high level is correlated with better left ventricular function, PLoS ONE, vol.12, p.172833, 2017. ,
Immunohistochemical characterization of infiltrating cells in human chronic chagasic myocarditis: comparison with myocardial rejection process, Virchows Arch A Pathol Anat Histopathol, vol.423, pp.157-60, 1993. ,
Characterization of inflammatory infiltrates in chronic chagasic myocardial lesions: presence of tumor necrosis factor-alpha+ cells and dominance of granzyme A+, CD8+ lymphocytes, Am J Trop Med Hyg, vol.48, pp.637-681, 1993. ,
An in situ quantitative immunohistochemical study of cytokines and IL2R+ in chronic human chagasic myocarditis: correlation with the presence of myocardial Trypanosoma cruzi antigens, Clin Immunol Immunopathol, vol.83, pp.165-72, 1997. ,
Locally produced survival cytokines IL-15 and IL-7 may be associated to the predominance of CD8+ T cells at heart lesions of human chronic Chagas disease cardiomyopathy, Scand J Immunol, vol.66, pp.362-71, 2007. ,
Chronic Chagas' disease cardiomyopathy patients display an increased IFN-gamma response to Trypanosoma cruzi infection, J Autoimmun, vol.17, pp.99-107, 2001. ,
In situ expression of regulatory cytokines by heart inflammatory cells in Chagas' disease patients with heart failure, Clin Dev Immunol, p.361730, 2012. ,
Myocardial gene expression of T-bet, GATA-3, Ror-?t, FoxP3, and hallmark cytokines in chronic Chagas disease cardiomyopathy: an essentially unopposed TH1-type response, Mediators Inflamm, p.914326, 2014. ,
Type 1 chemokine receptor expression in Chagas' disease correlates with morbidity in cardiac patients, Infect Immun, vol.73, pp.7960-7966, 2005. ,
Cardiac gene expression profiling provides evidence for cytokinopathy as a molecular mechanism in Chagas' disease cardiomyopathy, Am J Pathol, vol.167, issue.10, pp.62976-62984, 2005. ,
Myocardial chemokine expression and intensity of myocarditis in chagas cardiomyopathy are controlled by polymorphisms in CXCL9 and CXCL10, Plos Negl Trop Dis, vol.6, p.186, 2012. ,
Reprogramming of the macrophage transcriptome in response to interferon-gamma and Mycobacterium tuberculosis: signaling roles of nitric oxide synthase-2 and phagocyte oxidase, J Exp Med, vol.194, pp.1123-1163, 2001. ,
Could interferon-gamma be a therapeutic target for treating heart failure?, Heart Fail Rev, vol.19, pp.227-263, 2014. ,
Modulation of the activation of Stat1 by the interferon-gamma receptor complex, Cell Res, vol.16, pp.113-136, 2006. ,
Integration of miRNA and gene expression profiles suggest a role for miRNAs in the pathobiological processes of acute Trypanosoma cruzi infection. Sci Rep, vol.7, p.17990, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01698245
Interferon-gamma induces chronic active myocarditis and cardiomyopathy in transgenic mice, Am J Pathol, vol.171, pp.463-72, 2007. ,
Chronic inflammatory cardiomyopathy of interferon ?-overexpressing transgenic mice is mediated by tumor necrosis factor-?, Am J Pathol, vol.180, pp.73-81, 2012. ,
Endotoxin and cytokines alter contractile protein expression in cardiac myocytes in vivo, Pflugers Arch, vol.442, pp.920-927, 2001. ,
Selective inhibition of STAT3 phosphorylation by sodium salicylate in cardiac fibroblasts, Biochem Pharmacol, vol.63, pp.1197-207, 2002. ,
Catalase protects cardiomyocytes via its inhibition of nitric oxide synthesis, Nitric Oxide, vol.14, pp.189-99, 2006. ,
STAT1/3 and ERK1/2 synergistically regulate cardiac fibrosis induced by high glucose, Cell Physiol Biochem, vol.32, pp.960-71, 2013. ,
Modulation of MMP-2 (gelatinase A) and MMP-9 (gelatinase B) by interferon-gamma in a human salivary gland cell line, J Cell Physiol, vol.171, pp.117-141, 1997. ,
Expert consensus document: mitochondrial function as a therapeutic target in heart failure, Nat Rev Cardiol, vol.14, pp.238-250, 2017. ,
DOI : 10.1038/nrcardio.2016.203
URL : https://www.nature.com/articles/nrcardio.2016.203.pdf
SIRT1-PGC1?-NF?B pathway of oxidative and inflammatory stress during Trypanosoma cruzi infection: benefits of SIRT1-targeted therapy in improving heart function in Chagas disease, PLoS Pathog, vol.12, 2016. ,
Selective decrease of components of the creatine kinase system and ATP synthase complex in chronic Chagas disease cardiomyopathy, PLoS Negl Trop Dis, vol.5, 2011. ,
Defects of mtDNA replication impaired mitochondrial biogenesis during Trypanosoma cruzi infection in human cardiomyocytes and chagasic patients: the role of Nrf1/2 and antioxidant response, J Am Heart Assoc, vol.1, p.3855, 2012. ,
Characterization of inducible nitric oxide synthase expression in endotoxemic rat cardiac myocytes in vivo and following cytokine exposure in vitro, J Mol Cell Cardiol, vol.27, pp.2015-2044, 1995. ,
Response of the neonatal rat cardiomyocyte in culture to energy depletion: effects of cytokines, nitric oxide, and heat shock proteins, Lab Invest, vol.75, pp.809-827, 1996. ,
Interferon-gamma inhibits proliferation, differentiation, and creatine kinase activity of cultured human muscle cells. II. A possible role in myositis, J Rheumatol, vol.20, pp.1718-1741, 1993. ,
The role of STAT1/IRF-1 on synergistic ROS production and loss of mitochondrial transmembrane potential during hepatic cell death induced by ,
, J Mol Biol, vol.369, pp.967-84, 2007.
Mitochondrial membrane potential, Anal Biochem, vol.552, pp.50-59, 2017. ,
The NO/ONOO-cycle as the central cause of heart failure, Int J Mol Sci, vol.14, 2013. ,
ROS and Trypanosoma cruzi: fuel to infection, poison to the heart, PLoS Pathog, vol.14, p.1006928, 2018. ,
Antagonistic crosstalk between NF-?B and SIRT1 in the regulation of inflammation and metabolic disorders, Cell Signal, vol.25, pp.1939-1987, 2013. ,
Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut, Mucosal Immunol, vol.7, pp.1467-79, 2014. ,
Resveratrol reverses functional chagas heart disease in mice, PLoS Pathog, vol.12, 2016. ,
Inhibition of NFE2L2-antioxidant response element pathway by mitochondrial reactive oxygen species contributes to development of cardiomyopathy and left ventricular dysfunction in Chagas disease, Antioxid Redox Signal, vol.27, pp.550-66, 2017. ,
Nrf2 regulates ROS production by mitochondria and NADPH oxidase, Biochim Biophys Acta, vol.1850, pp.794-801, 2015. ,
The emerging role of Nrf2 in mitochondrial function, Free Radic Biol Med, pp.179-88, 2015. ,
Mitochondria in innate immune responses, Nat Rev Immunol, vol.11, pp.389-402, 2011. ,
Inflammation-cause or consequence of heart failure or both? Curr Heart Fail Rep, vol.14, pp.251-65, 2017. ,
Physical activity, opportunity for reinfection, and sibling history of heart disease as risk factors for Chagas' cardiopathy, Am J Trop Med Hyg, vol.43, pp.498-505, 1990. ,
Mannose-binding lectin and Toll-like receptor polymorphisms and Chagas disease in Chile, Am J Trop Med Hyg, vol.86, pp.229-261, 2012. ,
Tumor necrosis factor-alpha promoter polymorphism in Mexican patients with Chagas' disease, PLoS Negl Trop Dis, vol.98, pp.97-102, 2005. ,
Genetic polymorphisms in TNFA/TNFR2 genes and Chagas disease in a Colombian endemic population, Cytokine, vol.57, pp.398-401, 2012. ,
TNF gene polymorphisms are associated with reduced survival in severe Chagas' disease cardiomyopathy patients, Microbes Infect, vol.8, pp.598-603, 2006. ,
Polymorphism in the 3' UTR of the IL12B gene is associated with Chagas' disease cardiomyopathy, Microbes Infect, vol.9, pp.1049-52, 2007. ,
Role of the IFNG +874T/A polymorphism in Chagas disease in a Colombian population, Infect Genet Evol, vol.10, pp.682-687, 2010. ,
The gene-immune-behavioral pathway: Gamma-interferon (IFN-?) simultaneously coordinates susceptibility to infectious disease and harm avoidance behaviors, Brain Behav Immun, vol.35, pp.169-75, 2014. ,
Genetic susceptibility to Chagas disease cardiomyopathy: involvement of several genes of the innate immunity and chemokine-dependent migration pathways, BMC Infect Dis, vol.13, p.587, 2013. ,
URL : https://hal.archives-ouvertes.fr/inserm-00920392
Genetic variants in the chemokines and chemokine receptors in Chagas disease, Hum Immunol, vol.73, pp.852-860, 2012. ,
Genetic susceptibility to cardiac and digestive clinical forms of chronic Chagas disease, involvement of the CCR5 59029 A/G polymorphism, PLoS ONE, vol.10, 2015. ,
SNP/haplotype associations of CCR2 and CCR5 genes with severity of chagasic cardiomyopathy, Hum Immunol, vol.75, pp.1210-1215, 2014. ,
Functional IL-10 gene polymorphism is associated with Chagas disease cardiomyopathy, J Infect Dis, vol.199, pp.451-455, 2009. ,
Polymorphisms at tumor necrosis factor (TNF) loci are not associated with Chagas' disease, Tissue Antigens, vol.52, pp.81-84, 1998. ,
Association between the lymphotoxin-alpha gene polymorphism and chagasic cardiopathy, J Interferon Cytokine Res, vol.33, pp.130-135, 2013. ,
Heterozygosity for the S180L variant of MAL/TIRAP, a gene expressing an adaptor protein in the Toll-like receptor pathway, is associated with lower risk of developing chronic Chagas cardiomyopathy, J Infect Dis, vol.199, pp.1838-1883, 2009. ,
A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis, Nat Genet, vol.39, pp.523-531, 2007. ,
Serum profiles of C-C chemokines in acute myocardial infarction: possible implication in postinfarction left ventricular remodeling, J Interferon Cytokine Res, vol.22, pp.223-232, 2002. ,
Elevated circulating levels of C-C chemokines in patients with congestive heart failure, Circulation, vol.97, pp.1136-1179, 1998. ,
The monocyte chemoattractant protein-1 gene polymorphism is associated with cardiomyopathy in human chagas disease, Clin Infect Dis, vol.43, pp.305-316, 2006. ,
Chemokine receptor CCR5 polymorphisms and Chagas' disease cardiomyopathy, Tissue Antigens, vol.58, pp.154-162, 2001. ,
Is the CCR5-59029-G/G genotype a protective factor for cardiomyopathy in Chagas disease?, Hum Immunol, vol.65, pp.725-733, 2004. ,
The role of CCR5 in Chagas disease-a systematic review, Infect Genet Evol, vol.45, pp.132-139, 2016. ,
Insulin gene enhancer activity is inhibited by adenovirus 5 E1a gene products, Mol Cell Biol, vol.9, pp.4531-4535, 1989. ,
Interleukin 4, interleukin 4 receptor-? and interleukin 10 gene polymorphisms in Chagas disease, Parasite Immunol, vol.33, pp.506-517, 2011. ,
Trypanosoma cruzi DTU TcII presents higher blood parasitism than DTU TcI in an experimental model of mixed infection, Acta Parasitol, vol.60, pp.435-476, 2015. ,
Comparative pathogenicity in Swiss mice of Trypanosoma cruzi IV from northern Brazil and Trypanosoma cruzi II from southern Brazil, Exp Parasitol, vol.146, pp.34-42, 2014. ,
Differential Activation of human monocytes and lymphocytes by distinct strains of Trypanosoma cruzi, PLoS Negl Trop Dis, vol.9, p.3816, 2015. ,
Short communication: Trypanosoma cruzi lineage I in endomyocardial biopsy from a north-eastern Brazilian patient at end-stage chronic Chagasic cardiomyopathy, Trop Med Int Health, vol.11, pp.294-302, 2006. ,
Trypanosoma cruzi discrete typing units in Chagas disease patients from endemic and non-endemic regions of Argentina, Parasitology, vol.139, pp.516-537, 2012. ,
Immunological identification of Trypanosoma cruzi lineages in human infection along the endemic area, Am J Trop Med Hyg, vol.84, pp.78-84, 2011. ,
Discrete typing units of Trypanosoma cruzi detected by real-time PCR in Chilean patients with chronic Chagas cardiomyopathy, Acta Trop, vol.185, pp.280-284, 2018. ,
TLR4 and TLR9 are differentially modulated in liver lethally injured from BALB/c and C57BL/6 mice during Trypanosoma cruzi acute infection, Mol Immunol, vol.45, pp.3580-3588, 2008. ,