Journal articles
Inhibitory Effects of Ethanol in the Neonatal Rat Hippocampus In Vivo
Abstract : Ethanol-induced neuroapoptosis in the developing brain has been suggested to involve suppression of neuronal activity. However, ethanol acts as a potent stimulant of neuro-nal activity by increasing the frequency of depolarizing GABA dependent giant depolarizing potentials in the neonatal rat hippocampal slices in vitro. Here, we show that ethanol strongly inhibits, in a dose-dependent manner (1-6 g/kg), sharp waves and multiple unit activity in the hippocampus of neonatal (postnatal days P4-6) rats in vivo. Thus, the effects of ethanol on the developing hippocampal network activity cardinally differ in vitro (stimulation) and in vivo (inhibition).
Cited literature [15 references]
https://hal-amu.archives-ouvertes.fr/hal-01962095
Contributor : Christophe Pellegrino Connect in order to contact the contributor
Submitted on : Thursday, December 20, 2018 - 1:39:06 PM
Last modification on : Wednesday, November 3, 2021 - 6:45:14 AM
Long-term archiving on: : Friday, March 22, 2019 - 11:06:38 AM
Contributor : Christophe Pellegrino Connect in order to contact the contributor
Submitted on : Thursday, December 20, 2018 - 1:39:06 PM
Last modification on : Wednesday, November 3, 2021 - 6:45:14 AM
Long-term archiving on: : Friday, March 22, 2019 - 11:06:38 AM
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Chernova_BioNano 2017.pdf
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