Inhibitory Effects of Ethanol in the Neonatal Rat Hippocampus In Vivo

Kseniya Chernova , Gulshat Burkhanova , Andrey Zakharov (1) , Roustem Khazipov (2, 3) , Guzel Sitdikova

1 Laboratory of Neurobiology
2 KFU - Kazan Federal University
3 INMED - INSERM U901 - Institut de Neurobiologie de la Méditerranée [Aix-Marseille Université]

Ethanol-induced neuroapoptosis in the developing brain has been suggested to involve suppression of neuronal activity. However, ethanol acts as a potent stimulant of neuro-nal activity by increasing the frequency of depolarizing GABA dependent giant depolarizing potentials in the neonatal rat hippocampal slices in vitro. Here, we show that ethanol strongly inhibits, in a dose-dependent manner (1-6 g/kg), sharp waves and multiple unit activity in the hippocampus of neonatal (postnatal days P4-6) rats in vivo. Thus, the effects of ethanol on the developing hippocampal network activity cardinally differ in vitro (stimulation) and in vivo (inhibition).

Keywords: Hippocampus; Ethanol; Electroencephalography; Sharp wave-ripple; Rat; Neonate

Domains: Life Sciences [q-bio]; Neurons and Cognition [q-bio.NC]

Kseniya Chernova, Gulshat Burkhanova, Andrey Zakharov, Roustem Khazipov, Guzel Sitdikova. Inhibitory Effects of Ethanol in the Neonatal Rat Hippocampus In Vivo. BioNanoScience, 2017, 7 (1), pp.159-161. ⟨10.1007/s12668-016-0328-4⟩. ⟨hal-01962095⟩