Abstract : Ethanol-induced neuroapoptosis in the developing brain has been suggested to involve suppression of neuronal activity. However, ethanol acts as a potent stimulant of neuro-nal activity by increasing the frequency of depolarizing GABA dependent giant depolarizing potentials in the neonatal rat hippocampal slices in vitro. Here, we show that ethanol strongly inhibits, in a dose-dependent manner (1-6 g/kg), sharp waves and multiple unit activity in the hippocampus of neonatal (postnatal days P4-6) rats in vivo. Thus, the effects of ethanol on the developing hippocampal network activity cardinally differ in vitro (stimulation) and in vivo (inhibition).
https://hal-amu.archives-ouvertes.fr/hal-01962095 Contributor : Christophe PellegrinoConnect in order to contact the contributor Submitted on : Thursday, December 20, 2018 - 1:39:06 PM Last modification on : Wednesday, November 3, 2021 - 6:45:14 AM Long-term archiving on: : Friday, March 22, 2019 - 11:06:38 AM