Journal articles
Inhibitory Effects of Ethanol in the Neonatal Rat Hippocampus In Vivo
Abstract : Ethanol-induced neuroapoptosis in the developing brain has been suggested to involve suppression of neuronal activity. However, ethanol acts as a potent stimulant of neuro-nal activity by increasing the frequency of depolarizing GABA dependent giant depolarizing potentials in the neonatal rat hippocampal slices in vitro. Here, we show that ethanol strongly inhibits, in a dose-dependent manner (1-6 g/kg), sharp waves and multiple unit activity in the hippocampus of neonatal (postnatal days P4-6) rats in vivo. Thus, the effects of ethanol on the developing hippocampal network activity cardinally differ in vitro (stimulation) and in vivo (inhibition).
Cited literature [15 references]
https://hal-amu.archives-ouvertes.fr/hal-01962095
Contributor : Christophe Pellegrino <>
Submitted on : Thursday, December 20, 2018 - 1:39:06 PM
Last modification on : Monday, May 25, 2020 - 2:32:04 PM
Long-term archiving on: : Friday, March 22, 2019 - 11:06:38 AM
Contributor : Christophe Pellegrino <>
Submitted on : Thursday, December 20, 2018 - 1:39:06 PM
Last modification on : Monday, May 25, 2020 - 2:32:04 PM
Long-term archiving on: : Friday, March 22, 2019 - 11:06:38 AM
File
Chernova_BioNano 2017.pdf
Publication funded by an institution
Licence
Distributed under a Creative Commons Attribution 4.0 International License