Glutamate clearance is locally modulated by presynaptic terminal activity in the cerebral cortex, J Neurosci, vol.36, pp.10404-10415, 2016. ,
Cooperation between independent hippocampal synapses is controlled by glutamate uptake, Nat Neurosci, vol.5, pp.325-331, 2002. ,
Extrasynaptic glutamate spillover in the hippocampus: Dependence on temperature and the role of active glutamate uptake, Neuron, vol.18, pp.281-293, 1997. ,
Electrogenic uptake of glutamate and aspartate into glial cells isolated from the salamander (Ambystoma) retina, J Physiol, vol.436, pp.169-193, 1991. ,
Inhibition of M? uller cell glutamine synthetase rapidly impairs the retinal response to light, Glia, vol.30, pp.64-73, 2000. ,
Clearance of glutamate inside the synapse and beyond, Curr Opin Neurobiol, vol.9, pp.293-298, 1999. ,
Glial contribution to glutamate uptake at Schaffer collateral-commissural synapses in the hippocampus, J Neurosci, vol.18, pp.7709-7716, 1998. ,
Comparison of coupled and uncoupled currents during glutamate uptake by GLT-1 transporters, J Neurosci, vol.22, pp.10153-10162, 2002. ,
Electrogenic glutamate uptake is a major current carrier in the membrane of axolotl retinal glial cells, Nature, vol.327, pp.707-709, 1987. ,
Astrocyte glutamine synthetase:Importance in hyperammonemic syndromes and potential target for therapy, Neurotherapeutics, vol.7, pp.452-470, 2010. ,
, GS Inhibition Reduces EAATs Efficiency Month, p.13, 2016.
Generation of slow network oscillations in the developing rat hippocampus after blockade of glutamate uptake, J Neurophysiol, vol.98, pp.2324-2336, 2007. ,
URL : https://hal.archives-ouvertes.fr/inserm-00483859
Tonic release of glutamate by a DIDS-sensitive mechanism in rat hippocampal slices, J Physiol, vol.564, pp.397-410, 2005. ,
Tonic excitation and inhibition of neurons: ambient transmitter sources and computational consequences, Prog Biophys Mol Biol, vol.87, pp.3-16, 2005. ,
A quantitative analysis ofLglutamate-regulated Na1 dynamics in mouse cortical astrocytes: implications for cellular bioenergetics, Eur J Neurosci, vol.12, pp.3843-3853, 2000. ,
Selection of two lines of mice based on latency to onset of methionine sulfoximine seizures, Epilepsia, vol.51, pp.118-128, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-00911553
Astrocytic regulation of glutamate homeostasis in epilepsy, Glia, vol.60, pp.1215-1226, 2012. ,
Glutamate uptake, Prog Neurobiol, vol.65, pp.1-105, 2001. ,
Neuronal vs glial glutamate uptake: resolving the conundrum, Neuroch Int, vol.98, pp.29-45, 2016. ,
Paracrine intercellular communication by a Ca 21 and SNARE-independent release of GABA and glutamate prior to synapse formation, Neuron, vol.36, pp.1051-1061, 2002. ,
Glutamate transporters prevent the generation of seizures in the developing rat neocortex, J Neurosci, vol.24, pp.3289-3294, 2004. ,
URL : https://hal.archives-ouvertes.fr/inserm-00484643
Neuronal glutamate transporters limit activation of NMDA receptors by neurotransmitter spillover on CA1 pyramidal cells, J Neurosci, vol.21, pp.8328-8338, 2001. ,
Synaptically released glutamate does not overwhelm transporters on hippocampal astrocytes during high-frequency stimulation, J Neurophysiol, vol.83, pp.2835-2843, 2000. ,
Loss of glutamine synthetase in the human epileptogenic hippocampus: Possible mechanism for raised extracellular glutamate in mesial temporal lobe epilepsy, Lancet, vol.363, pp.28-37, 2004. ,
Recurrent seizures and brain pathology after inhibition of glutamine synthetase in the hippocampus in rats, Brain, vol.131, pp.2061-2070, 2008. ,
Regulation of astrocyte glutamine synthetase in epilepsy, Neurochem Int, vol.63, pp.670-681, 2013. ,
Electrogenic glutamate transporters in the CNS: Molecular mechanism, pre-steady-state kinetics, and their impact on synaptic signaling, J Membr Biol, vol.203, pp.1-20, 2005. ,
Congenital glutamine deficiency with glutamine synthetase mutations, N Engl J Med, vol.353, pp.1926-1933, 2005. ,
Natural course of glutamine synthetase deficiency in a 3 year old patient, Mol Genet Metab, vol.103, pp.89-91, 2011. ,
Astrocytic glutamate uptake is slow and does not limit neuronal NMDA receptor activation in the neonatal neocortex, Glia, vol.63, pp.1784-1796, 2015. ,
Glutamine synthetase deficiency in murine astrocytes results in neonatal death, Glia, vol.58, pp.741-754, 2010. ,
Astrocytic control of glutamatergic activity: astrocytes as stars of the show, Trends Neurosci, vol.27, pp.735-743, 2004. ,
Extracellular glutamate concentration in hippocampal slice, J Neurosci, vol.27, pp.9736-9741, 2007. ,
Glutamate transporters bring competition to the synapse, Curr Opin Neurobiol, vol.14, pp.346-352, 2004. ,
Inhibition of uptake unmasks rapid extracellular turnover of glutamate of nonvesicular origin, Proc Natl Acad Sci U S A, vol.96, pp.8733-8738, 1999. ,
Developmental profile and properties of sulforhodamine 101-labeled glial cells in acute brain slices of rat hippocampus, J Neurosci Methods, vol.169, pp.84-92, 2008. ,
Ammonium-evoked alterations in intracellular sodium and pH reduce glial glutamate transport activity, Glia, vol.57, pp.921-934, 2009. ,
Glutamine from glial cells is essential for the maintenance of the nerve terminal pool of glutamate: Immunogold evidence from hippocampal slice cultures, J Neurochem, vol.65, pp.871-881, 1995. ,
Astroglial contribution to brain energy metabolism in humans revealed by 13C nuclear magnetic resonance spectroscopy: Elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism, J Neurosci, vol.22, pp.1523-1531, 2002. ,
Tonic activation of NMDA receptors by ambient glutamate of non-synaptic origin in the rat hippocampus, J Physiol, vol.580, pp.373-383, 2007. ,
Dynamic regulation of synaptic GABA release by the glutamate-glutamine cycle in hippocampal area CA1, J Neurosci, vol.26, pp.8537-8548, 2006. ,
Glutamate transporters: animal models to neurological disease, Neurobiol Dis, vol.15, pp.461-473, 2004. ,
Role of glial amino acid transporters in synaptic transmission and brain energetics, Glia, vol.47, pp.217-225, 2004. ,
Maintaining the presynaptic glutamate supply for excitatory neurotransmission, J Neurosci Res, vol.93, pp.1031-1044, 2015. ,
Synaptic localization of GLT-1a in the rat somatic sensory cortex, Glia, vol.57, pp.108-117, 2009. ,
Inhibition of glutamate transporters results in a "suppression-burst" pattern and partial seizures in the newborn rat, Epilepsia, vol.48, pp.169-174, 2007. ,
URL : https://hal.archives-ouvertes.fr/inserm-00483529
Glutamate transporters control metabotropic glutamate receptors activation to prevent the genesis of paroxysmal burst in the developing hippocampus, Neuroscience, vol.207, pp.25-36, 2012. ,
Surface diffusion of astrocytic glutamate transporters shapes synaptic transmission, Nat Neurosci, vol.18, pp.219-226, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01154386
Beyond the role of glutamate as a neurotransmitter, Nat Rev Neurosci, vol.3, pp.748-755, 2002. ,
Selective induction of astrocytic gliosis generates deficits in neuronal inhibition, Nat Neurosci, vol.13, pp.584-591, 2010. ,
Anion currents and predicted glutamate flux through a neuronal glutamate transporter, J Neurosci, vol.18, pp.7099-7110, 1998. ,
Evidence for astrocytes as a potential source of the glutamate excess in temporal lobe epilepsy, Neurobiol Dis, vol.47, pp.331-337, 2012. ,
Neuronal transporters regulate glutamate clearance, NMDA receptor activation, and synaptic plasticity in the hippocampus, J Neurosci, vol.29, pp.14581-14595, 2009. ,
Methionine sulfoximine seizures. The dissociation of the convulsant and glutamine synthetase inhibitory effects, J Pharmacol Exp Ther, vol.164, pp.212-222, 1968. ,
A neuronal glutamate transporter contributes to neurotransmitter GABA synthesis and epilepsy, J Neurosci, vol.22, pp.6372-6379, 2002. ,
The role of glutamate transporters in glutamate homeostasis in the brain, J Exp Biol, vol.200, pp.401-409, 1997. ,
Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1, Science, vol.276, pp.1699-1702, 1997. ,
,
, A local glutamate-glutamine cycle sustains synaptic excitatory transmitter release, Neuron, vol.81, pp.888-900
Glutamine is required to persistent epileptiform activity in disinhibited neocortical brain slice, J Neurosci, vol.30, pp.1288-1300, 2010. ,
The relative roles of diffusion and uptake in clearing synaptically released glutamate change during early postnatal development, J Neurosci, vol.31, pp.4743-4754, 2011. ,
Glutamate transporters: Confining runaway excitation by shaping synaptic transmission, Nat Rev Neurosci, vol.8, pp.935-947, 2007. ,
DOI : 10.1038/nrn2274
Mechanisms of glutamate transport, Physiol Rev, vol.93, pp.1621-1657, 2013. ,
Kinetics of a human glutamate transporter, Neuron, vol.14, pp.1019-1027, 1995. ,
Intrinsic kinetics determine the time course of neuronal synaptic transporter currents, Proc Natl Acad Sci, vol.103, pp.1083-1087, 2006. ,
EAAT2 (GLT-1; slc1a2) glutamate transporters reconstituted in liposomes argues against heteroexchange being substantially faster than net uptake, J Neurosci, vol.34, pp.13472-13485, 2014. ,