Dynamic spike threshold reveals a mechanism for synaptic coincidence detection in cortical neurons in vivo, Proceedings of the National Academy of Sciences of the United States of America, vol.97, pp.8110-8115, 2000. ,
DOI : 10.1073/pnas.130200797
URL : https://www.pnas.org/content/pnas/97/14/8110.full.pdf
Loss of the cisternal organelle in the axon initial segment of cortical neurons in synaptopodin-deficient mice, Journal of Comparative Neurology, vol.504, pp.441-449, 2007. ,
The action potential in mammalian central neurons, Nature Review Neuroscience, vol.8, pp.451-465, 2007. ,
DOI : 10.1038/nrn2148
Dopaminergic modulation of axon initial segment calcium channels regulates action potential initiation, Neuron, vol.68, pp.500-511, 2010. ,
DOI : 10.1016/j.neuron.2010.09.026
URL : https://doi.org/10.1016/j.neuron.2010.09.026
The physiology of the axon initial segment, Annual Review of Neuroscience, vol.35, pp.249-265, 2012. ,
The cisternal organelle as a Ca(2+)-storing compartment associated with GABAergic synapses in the axon initial segment of hippocampal pyramidal neurones, Experimental Brain Research, vol.101, pp.216-230, 1994. ,
Localized myosin II activity regulates assembly and plasticity of the axon initial segment, Neuron, vol.97, p.556, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01701359
Sharpness of spike initiation in neurons explained by compartmentalization, PLoS Computational Biology, vol.9, p.1003338, 2013. ,
GABAergic and glutamatergic axons innervate the axon initial segment and organize GABA(A) receptor clusters of cultured hippocampal pyramidal cells, Journal of Comparative Neurology, vol.456, pp.361-374, 2003. ,
Spike-time precision and network synchrony are controlled by the homeostatic regulation of the D-type potassium current, Journal of Neuroscience, vol.30, pp.12885-12895, 2010. ,
URL : https://hal.archives-ouvertes.fr/hal-01766845
ATP-P2X7 receptor modulates axon initial segment composition and function in physiological conditions and brain injury, Cerebral Cortex, vol.25, pp.2282-2294, 2015. ,
URL : https://hal.archives-ouvertes.fr/hal-01766835
Calcineurin signaling mediates activity-dependent relocation of the axon initial segment, Journal of Neuroscience, vol.33, pp.6950-6963, 2013. ,
DOI : 10.1523/jneurosci.0277-13.2013
URL : http://www.jneurosci.org/content/33/16/6950.full.pdf
A targeting motif involved in sodium channel clustering at the axonal initial segment, Science, vol.300, pp.2091-2094, 2003. ,
DOI : 10.1126/science.1085167
URL : https://digital.csic.es/bitstream/10261/145898/1/accesoRestringido.pdf
Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability, Nature, vol.465, pp.1070-1074, 2010. ,
DOI : 10.1038/nature09160
URL : http://europepmc.org/articles/pmc3196626?pdf=render
AnkyrinG is required for maintenance of the axon initial segment and neuronal polarity, Journal of Cell Biology, vol.183, pp.635-640, 2008. ,
DOI : 10.1083/jcb.200806112
URL : http://jcb.rupress.org/content/jcb/183/4/635.full.pdf
Kv1 channels control spike threshold dynamics and spike timing in cortical pyramidal neurones, Journal of Physiology, vol.589, pp.5125-5142, 2011. ,
DOI : 10.1113/jphysiol.2011.216721
URL : https://physoc.onlinelibrary.wiley.com/doi/pdf/10.1113/jphysiol.2011.216721
Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation, Nature Neuroscience, vol.12, pp.996-1002, 2009. ,
Myosin-V induces cargo immobilization and clustering at the axon initial segment, Frontiers in Cellular Neuroscience, vol.11, p.260, 2017. ,
DOI : 10.3389/fncel.2017.00260
URL : https://www.frontiersin.org/articles/10.3389/fncel.2017.00260/pdf
Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments, Journal of Cell Biology, vol.155, pp.739-746, 2001. ,
DOI : 10.1083/jcb.200109026
URL : http://jcb.rupress.org/content/155/5/739.full.pdf
Trafficking of Kv2.1 channels to the axon initial segment by a novel nonconventional secretory pathway, Journal of Neuroscience, vol.37, pp.11523-11536, 2017. ,
Serotonin modulates spike probability in the axon initial segment through HCN channels, Nature Neuroscience, vol.19, pp.826-834, 2016. ,
A functional barrier to movement of lipids in polarized neurons, Nature, vol.359, pp.647-650, 1992. ,
Action potential generation requires a high sodium channel density in the axon initial segment, Nature Neuroscience, vol.11, pp.178-186, 2008. ,
Is action potential threshold lowest in the axon?, Nature Neuroscience, vol.11, pp.1253-1255, 2008. ,
Presynaptic activity regulates Na(+) channel distribution at the axon initial segment, Nature, vol.465, pp.1075-1078, 2010. ,
Redistribution of Kv1 and Kv7 enhances neuronal excitability during structural axon initial segment plasticity, Nature Communications, vol.6, p.8815, 2015. ,
M-current inhibition rapidly induces a unique CK2-dependent plasticity of the axon initial segment, Proceedings of the National Academy of Sciences of the United States of America, vol.114, pp.10234-10243, 2017. ,
Immunocytochemical localization of the alpha 1 and beta 2/3 subunits of the GABAA receptor in relation to specific GABAergic synapses in the dentate gyrus, European Journal of Neuroscience, vol.7, pp.630-646, 1995. ,
Postsynaptic density-93 clusters Kv1 channels at axon initial segments independently of Caspr2, Journal of Neuroscience, vol.28, pp.5731-5739, 2008. ,
The axon hillock and the initial segment, Journal of Cell Biology, vol.38, pp.193-201, 1968. ,
Site of action potential initiation in layer 5 pyramidal neurons, Journal of Neuroscience, vol.26, pp.1854-1863, 2006. ,
A common ankyrin-G-based mechanism retains KCNQ and Na V channels at electrically active domains of the axon, Journal of Neuroscience, vol.26, pp.2599-2613, 2006. ,
The spatio-temporal characteristics of action potential initiation in layer 5 pyramidal neurons: a voltage imaging study, Journal of Physiology, vol.589, pp.4167-4187, 2011. ,
The axon initial segment and the maintenance of neuronal polarity, Nature Review Neuroscience, vol.11, pp.552-562, 2010. ,
Developmental expression of Kv potassium channels at the axon initial segment of cultured hippocampal neurons, PLoS One, vol.7, 2012. ,
Casein kinase 2 and microtubules control axon initial segment formation, Molecular and Cellular Neuroscience, vol.46, pp.222-234, 2011. ,
Disruption of the axon initial segment cytoskeleton is a new mechanism for neuronal injury, Journal of Neuroscience, vol.29, pp.13242-13254, 2009. ,
Structural plasticity of synaptopodin in the axon initial segment during visual cortex development, Cerebral Cortex, vol.27, pp.4662-4675, 2017. ,
Selective stabilization of microtubules within the proximal region of developing axonal neurites, Brain Research Bulletin, vol.48, pp.255-261, 1999. ,
A selective filter for cytoplasmic transport at the axon initial segment, Cell, vol.136, pp.1148-1160, 2009. ,
Impaired function of HDAC6 slows down axonal growth and interferes with axon initial segment development, PLoS One, vol.5, p.12908, 2010. ,
GSK3 and beta-catenin determines functional expression of sodium channels at the axon initial segment, Cellular and Molecular Life Sciences, vol.70, pp.105-120, 2013. ,
Cannabinoid receptors modulate neuronal morphology and AnkyrinG density at the axon initial segment, Frontiers in Cellular Neuroscience, vol.11, p.5, 2017. ,
Localization and targeting of voltage-dependent ion channels in mammalian central neurons, Physiological Reviews, vol.88, pp.1407-1447, 2008. ,
TRIM46 controls neuronal polarity and axon specification by driving the formation of parallel microtubule arrays, Neuron, vol.88, pp.1208-1226, 2015. ,
Biophysical mechanism of spike threshold dependence on the rate of rise of the membrane potential by sodium channel inactivation or subthreshold axonal potassium current, Journal of Computational Neuroscience, vol.35, pp.1-17, 2013. ,
A diffusion barrier maintains distribution of membrane proteins in polarized neurons, Nature, vol.397, pp.698-701, 1999. ,
Actin, spectrin, and associated proteins form a periodic cytoskeletal structure in axons, Science, vol.339, pp.452-456, 2013. ,
Developmental changes in expression of betaIV spectrin splice variants at axon initial segments and nodes of ranvier, Frontiers in Cellular Neuroscience, vol.10, p.304, 2016. ,
Cortical action potential backpropagation explains spike threshold variability and rapid-onset kinetics, Journal of Neuroscience, vol.28, pp.7260-7272, 2008. ,
Structural requirements for association of neurofascin with ankyrin, Journal of Biological Chemistry, vol.273, pp.30785-30794, 1998. ,
Axon physiology, Physiological Reviews, vol.91, pp.555-602, 2011. ,
Axon initial segments: structure, function, and disease, Annals of the New York Academy of Sciences, vol.1420, pp.46-61, 2018. ,
Activity-dependent axonal plasticity in sensory systems, Neuroscience, vol.368, pp.268-282, 2018. ,
Signal processing in the axon initial segment, Neuron, vol.73, pp.235-247, 2012. ,
Structural tuning and plasticity of the axon initial segment in auditory neurons, Journal of Physiology, vol.590, pp.5571-5579, 2012. ,
The axon initial segment: an updated viewpoint, Journal of Neuroscience, vol.38, pp.2135-2145, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01736917
Signal propagation along the axon, Current Opinion in Neurobiology, vol.51, pp.37-44, 2018. ,
URL : https://hal.archives-ouvertes.fr/hal-01963472