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Somatic modulation of ectopic action potential initiation in distal axons

Abstract : Classically, action potentials are initiated at the axon initial segment (AIS) when the summed depolarizing events arising from the dendrites exceed a threshold value. Then, action potentials propagate along the axon before reaching presynaptic terminals where they cause local calcium influx and transmitter release. According to this scheme, the AIS is a major player since all propagated excitation is precisely initiated at this hot spot endowed with a high concentration of sodium channels.
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Submitted on : Friday, December 21, 2018 - 11:43:16 AM
Last modification on : Wednesday, November 3, 2021 - 5:50:17 AM
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Aurélie Fékété, Dominique Debanne. Somatic modulation of ectopic action potential initiation in distal axons. The Journal of Physiology, Wiley, 2018, 596 (21), pp.5067-5068. ⟨10.1113/jp277012⟩. ⟨hal-01963294⟩



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